Scientific Area of Research
Channels, synapses, and neural circuits are fundamental structural and functional elements of the nervous system. Detailed
and integrated knowledge of these elements is essential for understanding how the nervous system works under normal and abnormal
conditions. In recent years, remarkable progress and exciting discoveries have been made in the basic research in these areas;
only few of them, however, have been directly connected to mechanisms underlying the causes of numerous neurological disorders.
The major goals of our program are 1) to continue to support the ongoing basic and clinical research; 2) to foster research
on particular channels, synapses, and neural circuits that have immediate medical relevance; and 3) encourage translational
research that links the discoveries from basic research into medication development and therapeutic interventions for treating
neurological disorders, such as epilepsy.
Current Funding Announcements
*Note: The
Electronic Submission process for grant applications has begun at NIH. Register with
Grants.gov and
NIH eRA Commons so that you may
start preparing for this transtion
Funding announcement information is updated daily throughout the NINDS website. If individual funding announcements are not
listed below, it means that there are no current solicitations available for this particular Program Area. Please continue
to check this web page for the latest RFA's, PA's, RFP's and Notices related to this Program Area.
Program Announcements (PA)
(Sorted by Application Receipt Date)
-
Research Supplements to Promote Diversity in Health-Related Research [Summary]
Application Receipt Date: February 15, 2009
Announcement Number: PA-08-190
Funding Contact:
Michelle Jones-London, Ph.D.
Program Area:
Neural Environment, Neurodegeneration, Neurogenetics, Repair and Plasticity, Office of Minority Health and Research, Channels, Synapses and Neural Circuits, Office of Clinical Research, Systems and Cognitive Neuroscience
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Research Supplements to Promote Re-Entry into Biomedical and Behavioral Research Careers [Summary]
Application Receipt Date: February 15, 2009
Announcement Number: PA-08-191
Funding Contact:
Michelle Jones-London, Ph.D.
Program Area:
Neural Environment, Neurodegeneration, Neurogenetics, Repair and Plasticity, Office of Translational Research, Office of Minority Health and Research, Channels, Synapses and Neural Circuits, Office of Clinical Research, Systems and Cognitive Neuroscience
Notices (NOT)
(Sorted by Release Date)
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NIH/AHRQ Confirms Plans to Transition the G7, G8, G11, G13, G20, S11, S21 and S22 to Electronic Applications and Announces
Delay in Transition of K, F, T and Complex Grant Programs [Summary]
Release Date: January 19, 2007
Announcement Number: NOT-OD-07-038
Funding Contact: NINDS Funding
Program Area:
Neural Environment, Neurodegeneration, Neurogenetics, Repair and Plasticity, Office of Translational Research, Office of Training and Career Development, Office of Minority Health and Research, Channels, Synapses and Neural Circuits, Office of Clinical Research, Systems and Cognitive Neuroscience
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Policy Revision of the National Institute of Neurological Disorders and Stroke (NINDS) for Competing Program Project (P01)
and Unsolicited Center Grant (P50) Applications [Summary]
Release Date: May 15, 2007
Announcement Number: NOT-NS-07-010
Funding Contact:
Robert Finkelstein, Ph.D.
Program Area:
Neural Environment, Neurodegeneration, Neurogenetics, Repair and Plasticity, Office of Translational Research, Office of Training and Career Development, Office of Minority Health and Research, Channels, Synapses and Neural Circuits, Office of Clinical Research, Systems and Cognitive Neuroscience
-
Amendment to NOT-NS-07-010: Policy Revision of the National Institute of Neurological Disorders and Stroke (NINDS) for Competing
Program Project (P01/P50) Grant Applications [Summary]
Release Date: February 6, 2008
Announcement Number: NOT-NS-08-010
Funding Contact:
Emmeline Edwards, Ph.D.
Program Area:
Neural Environment, Neurodegeneration, Neurogenetics, Repair and Plasticity, Office of Translational Research, Office of Training and Career Development, Office of Minority Health and Research, Channels, Synapses and Neural Circuits, Office of Clinical Research, Systems and Cognitive Neuroscience, Office of Training and Career Development
Administrative and Research Supplements
(Sorted by Release Date)
View Archived AnnouncementsAdditional Information
Mission Statement
- The CSC cluster initiates and promotes basic, translational and clinical research in channels, synapses, and neural circuits
that underlie normal brain functions and dysfunctions related to neurological disorders, such as epilepsy and muscular dystrophy.
To advance the program in channels, synapses, and circuits, we will:
- Expand the structural analysis of neuronal membrane proteins, (e.g. ion channels, neurotransmitter receptors, and transporters)
to the atomic level by promoting crystallography of prokaryotic and critical domains of eukaryotic membrane proteins, and
other high resolution structural studies of non-crystallized membrane proteins
- Stimulate research on channelopathies and their relationship to neurological diseases (e.g., identifying physiological and
pathological roles of membrane proteins by combining molecular biology, electrophysiology, genetically-engineered animal models,
and behavioral tests)
- Foster studies on molecular and cellular mechanisms of synaptic transmission and synaptic plasticity, especially on neurotransmission-related
proteins, and dendritic research
- Promote neural circuit analysis by using improved in vitro electrophysiological recordings, and other innovative approaches
such as novel genetic methods to map functional neuronal circuits.
- Facilitate collaborations among researchers who are working at molecular, cellular and system levels to develop multidisciplinary
approaches for analysis of channel, synapses and circuits
- Facilitate collaborations among neuroscientists and computer scientists, informatics scientists, mathematicians, statisticians,
electrical engineers, and physicists to develop neuroinformatics tools for data archival, retrieval, transfer, and sharing,
and computational tools for data analysis and modeling
- Facilitate collaborations among basic researchers, the pharmaceutical industry, and clinicians to identify biological markers
and surrogate endpoints; to develop new diagnostic tools, drug delivery methods, and therapies, including conducting clinical
trials
- Create opportunities to train a new generation of multidisciplinary researchers in research in these areas
Quick Links
NINDS Epilepsy Information Page
Epilepsy Research Web
The "Benchmarks" For Epilepsy Research
Workshops and Summaries
Curing Epilepsy: Translating Discoveries into Therapies March 28-30, 2007
Workshop on Nonepileptic Seizures May 1-3, 2005
Proteomics in the Neurosciences December 9 - 10, 2002
Workshop on Channelopathies November 20-21, 2002
Curing Epilepsy: Focus on the Future March 30-31, 2000
Note: See Epilepsy Research Web for a complete listing of workshops
Personnel
Address
Channels, Synapses and Neural Circuits
Neuroscience Center, Room 2110
6001 Executive Boulevard
Bethesda, MD 20892-9523
Courier: Rockville, MD 20852-9523
Phone: 301/496-1917
Fax: 301/480-2424