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| Serena Dudek, Ph.D., Investigator |
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Dr. Dudek received her B.S. in 1986 from the University of California at Irvine, where she began working on synaptic plasticity in the hippocampus with Gary Lynch. In 1992, she received her Ph.D. from Brown University where she worked with Mark Bear on long-term synaptic depression in the hippocampus. Following postdoctoral work with Michael Friedlander and Gail Johnson at the University of Alabama at Birmingham, she joined the laboratory of Doug Fields at the NICHD. Dr. Dudek moved to NIEHS as an Investigator in 2001. Her laboratory studies the cellular mechanisms of synaptic plasticity in the adult and developing mammalian cortex.
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Staff:
- Natalia Bastrikova, Ph.D., Research Fellow, (919) 541-9807 bastrik1@niehs.nih.gov
- Kelly Daigle, Post baccalaureate Fellow, (919) 541-9807 diaglek@od.nih.gov
- J. Daniel Fenn, Postbaccalaureate IRTA, (919) 541-0221 fennjd@niehs.nih.gov
- Ramendra Saha, Ph.D., Visiting Fellow, (919) 541-0221 sahaR2@niehs.nih.gov
- Stephen Simons, Ph.D., IRTA Fellow, (919) 541-0221 simonsS2@niehs.nih.gov
- Meilan Zhao, Ph.D., Research Fellow, (919) 541-7680 zhao3@niehs.nih.gov
Research Interests:
During postnatal development, mammals, including humans, acquire vast amounts of information by interacting with their environments. In contrast to creatures having nervous systems
that are fully pre-wired at birth, mammals benefit from an enormous flexibility in behavior due to the driving force of experience on their brain development. This flexibility comes at a
potential cost, however, because interaction with noxious or otherwise abnormal environments can cause lasting and often deleterious changes in brain circuitry. Our working hypothesis
is that environmental insults during development can result in impaired human cognition during adulthood. One way this might happen is through an increased susceptibility to diseases
thought to have environmental components as risk factors (schizophrenia and Alzheimer's disease, for example). The research done in the Synaptic and Developmental Plasticity Group
focuses on determining how the connections in the brain (synapses) change in response to activity, how synaptic plasticity during early postnatal development is different from plasticity in
the adult, and why some brain regions are more plastic than others. This research should bring us a better understanding of how environmental factors play a role in brain development so
that we may begin to address the associated problems of brain disease caused by toxicant exposure.
We are working on three main projects in the lab:
1) Synapse elimination in the cerebral cortex during development (how experience shapes brain circuitry)
2) Circuitry in a layer of the cerebral cortex (layer IV) noted for its lack of plasticity, and incidentally, resistance to damage by Alzheimer's disease
3) Long-lasting changes in the strength of synapses, specifically how neuronal activity changes gene expression in neurons
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Selected Recent Publications:
Bastrikova, N., Gardner, G., Reece, J., Jeromin, A., and Dudek, S.M. (2008) Synapse elimination accompanies functional plasticity in hippocampal neurons., Proc Natl Acad Sci U S A 105, 3123-3127.
Adams, J.P., Robinson, R.A., and Dudek, S.M. (2007) Role of action potentials in regulating gene transcription: relevance to LTP, in: Transcriptional Regulation by Neuronal Activity. S.M. Dudek, ed..
Zhao, M., Choi, Y.-S., Obrietan, K., and Dudek, S.M. (2007) Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons., J. Neurosci. 27, 12058-12066.
Zhao, M., Adams, J.P., and Dudek, S.M. (2005) Pattern-Dependent Role of NMDA Receptors in Action Potential Generation: Consequences on Extracellular Signal-Regulated Kinase Activation , J. Neurosci. 25, 7032-7039.
Adams, J.P. and Dudek, S.M. (2005) Late-phase long-term potentiation: getting to the nucleus. , Nature Rev. Neurosci. 6, 737-743.
All Selected Publications
Contact Information:
Dr. Serena Dudek
Synaptic and Developmental Plasticity Unit
Laboratory of Neurobiology , NIEHS
111 Alexander Drive
Research Triangle Park, NC 27709-
Telephone: (919) 541-3275 (office),
Email: dudek@niehs.nih.gov
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