| Title: |
Polyglutamine-induced neurodegeneration [electronic resource] : pathogenesis is linked to native protein biochemistry function / Harry Orr. |
| Variant Title: |
Title on PowerPoint: Molecular basis of the polyglutamine neurogeneerative disease SCA1 |
| Author(s)/Name(s): |
Orr, Harry. |
| Publisher: |
[Bethesda, Md. : National Institutes of Health, 2007] |
| Related Names: |
National Institutes of Health (U.S.) |
| Series: |
NIH neuroscience seminar series |
| Language: |
eng |
| Electronic Links: |
http://videocast.nih.gov/launch.asp?14157 |
| MeSH Subjects: |
Spinocerebellar Ataxias --etiology |
|
Nuclear Proteins |
|
Nerve Tissue Proteins |
|
Lectures |
| Summary: |
(CIT): Dr. Orr discovered that an expanded glutamine tract in the ataxin-1 gene is the cause of the inherited neurodegenerative disease, spinocerebellar ataxia type 1 (SCA1). His current research focuses on understanding how polyglutamine tracts lead to neuronal dysfunction and neurodegeneration. His development of a conditional mouse model of Sca1 has yielded a number of insights into the molecular defects caused by the mutant ataxin-1 and how this affects Purkinje cell and cerebellar function and development. |
| Notes: |
Title from title screen (viewed Dec. 31, 2007). |
|
Streaming video (1 hr., 4 min. : sd., col.). |
|
Mode of access: World Wide Web. |
|
Open-captioned. |
| NLM Unique ID: |
101322969 |
| Other ID Numbers: |
(DNLM)CIT:14157 |
