| Title: |
Spontaneous rhythmic activity in spinal motor circuit formation [electronic resource] / Lynn Landmesser. |
| Author(s)/Name(s): |
Landmesser, Lynn T. |
| Publisher: |
[Bethesda, Md. : National Institutes of Health, 2007] |
| Related Names: |
National Institutes of Health (U.S.) |
| Language: |
eng |
| Electronic Links: |
http://videocast.nih.gov/launch.asp?13714 |
| MeSH Subjects: |
Spinal Cord --embryology |
|
Spinal Cord --physiology |
|
Motor Neurons --physiology |
|
Neural Pathways --embryology |
|
Neural Pathways --physiology |
|
Lectures |
| Summary: |
(CIT): Dr. Landmesser will present her research aimed at understanding the role that spontaneous electrical activity plays in the development of spinal cord motor circuits and neuromuscular maturation, and to elucidate the cellular mechanisms that produce such activity. Her laboratory found that such activity occurs during axon outgrowth and that it is required for accurate pathfinding. Unlike mature circuits which are driven by glutamate, early spontaneous activity in both chick and mouse require both cholinergic and GABAergic/glycinergic transmission as well as electrical coupling. By working out in more detail the circuit that produces spontaneous activity in wild type mice, her laboratory can now make use of various transgenic mice in which subpopulations of neurons are genetically deleted or altered. NIH Neuroscience Seminar Series. |
| Notes: |
Title from screen banner (viewed Apr. 4, 2007). |
|
Streaming video (1 hr., 11 min. : sd., col.). |
|
Mode of access: World Wide Web. |
|
Open-captioned. |
| NLM Unique ID: |
101303659 |
| Other ID Numbers: |
(DNLM)CIT:13714 |
