A New Decade of Public Health Genomics at CDC 10th anniversary event of public health genomics at CDC highlights scientific achievements and progress in genomics, genetics, and family history for improving the public’s health.
	CDC is sponsoring an ASHG Genetics and Public Health Research and Practice Program fellowship to enhance CDC’s current activities and develop new approaches in integrating genetics and genomics into public health policy and programs at the national, state, and local levels. The deadline to apply is March 15, 2008.
	New article “Cracking the Code, Integrating Asthma Genomics into Public Health” published in the March/April issue of Advance newsletter for Managers of Respiratory Care. See quotes by Dr. Muin J. Khoury and other experts.
	HuGENet™ What's New March 2008

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Efficient Approximation of P-value of the Maximum of Correlated Tests, with Applications to Genome-Wide Association Studies
Li Q, et al.
Ann Hum Genet 2008 Mar

The comet assay in human biomonitoring: gene-environment interactions
Dusinska M & Collins AR
Mutagenesis 2008 Mar

Genomics in the Era of Molecular Ophthalmology: Reflections on the National Ophthalmic Disease Genotyping Network (eyeGENE)
Brooks BP, et al.
Arch Ophthalmol 2008 Mar;126(3):424-5

Association between mitochondrial DNA mutations and cancer in human
Zhang SP, et al.
Yi Chuan 2008 Mar;30(3):263-8

PharmGKB and the International Warfarin Pharmacogenetics Consortium: the changing role for pharmacogenomic databases and single-drug pharmacogenetics
Owen RP, et al.
Hum Mutat 2008 Mar;29(4):456-60

Buccal Swabs and Treated Cards: Methodological Considerations for Molecular Epidemiologic Studies Examining Pediatric Populations
Beckett SM, et al.
Am J Epidemiol 2008 Mar

What's new in: "Genetics in childhood epilepsy"
Lagae L
Eur J Pediatr 2008 Mar

Primer: SNP-associated studies and what they can teach us
Yamada R
Nat Clin Pract Rheumatol 2008 Mar

A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions
Janssens AC, et al.
Am J Hum Genet 2008 Mar;82(3):593-9

Goldsurfer2 (Gs2): A comprehensive tool for the analysis and visualization of genome wide association studies
Pettersson F, et al.
BMC Bioinformatics 2008 Mar;9(1):138

Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions
Mechanic LE, et al.
BMC Bioinformatics 2008 Mar;9(1):146

Empirical Bayes analysis of single nucleotide polymorphisms
Schwender H & Ickstadt K
BMC Bioinformatics 2008 Mar;9(1):144

LabCorp v. Metabolite Laboratories: The Supreme Court Listens, but Declines to Speak
Klein RD & Mahoney MJ
J Law Med Ethics 2008 Spring;36(1):141-9

 

Genetic testing and breach of patient confidentiality: Law, ethics, and pragmatics
Minkoff H & Ecker J
Am J Obstet Gynecol 2008 Mar

Associations between Anticipated Reactions to Genetic Test Results and Interest in Genetic Testing: Will Self-Selection Reduce the Potential for Harm?
Sanderson SC & Wardle J
Genet Test 2008 Mar

Using the optimal receiver operating characteristic curve to design a predictive  genetic test, exemplified with type 2 diabetes
Lu Q & Elston RC
Am J Hum Genet 2008 Mar;82(3):641-51

 

Colonoscopy for screening and follow up of patients with a family history of colorectal cancer
Tytherleigh MG, et al.
Colorectal Dis 2008 Mar

Cancer incidence in patients with schizophrenia and their first-degree relatives  - a meta-analysis
Catts VS, et al.
Acta Psychiatr Scand 2008 Mar

Conjugal Alzheimer disease: risk in children when both parents have Alzheimer disease
Jayadev S, et al.
Arch Neurol 2008 Mar;65(3):373-8

The Accuracy of Cancer Diagnoses as Reported in Families with Head and Neck Cancer: a Case-Control Study
Jefferies S, et al.
Clin Oncol (R Coll Radiol) 2008 Mar

 

Genome-wide association studies in Alzheimer disease
Waring SC & Rosenberg RN
Arch Neurol 2008 Mar;65(3):329-34

Genome-wide association scans identified CTNNBL1 as a novel gene for obesity
Liu YJ, et al.
Hum Mol Genet 2008 Mar

Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33
Gold B, et al.
Proc Natl Acad Sci U S A 2008 Mar

A genome-wide association study in 574 schizophrenia trios using DNA pooling
Kirov G, et al.
Mol Psychiatry 2008 Mar

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending March 12, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorder
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions

For more information on HuGE, please visit the HuGENet™ home page