New article on “Letting the Genome out of the Bottle — Will We Get Our Wish?”   published in the January 10, 2008 issue of the New England Journal of Medicine. Authors: David J. Hunter, MB, BS, ScD, MPH, Muin J. Khoury, MD, PhD, and Jeffrey M. Drazen, MD. Listen to the audio interview.
	New editorial on "Why should genomic medicine become more evidence-based?" (126KB) published in the December 2007 issue of Genomic Medicine. Authors: Muin J. Khoury, MD, PhD and Linda A. Bradley, PhD.
	The independent EGAPP Working Group  released the first in a planned series of recommendation statements on the use of genetic tests in clinical practice. This first statement addresses the use of cytochrome P450 (CYP450) testing in adults with depression treated with a widely prescribed class of antidepressants. > Read more about the EGAPP initiative > Read CDC Press Statement
	CDC's National Office of Public Health Genomics announces a new funding opportunity for those interested in genomics translation research
	HuGENet™ What's New January 2008

• The following are headlines from on-line news articles published during the past week.
• The headlines and lead sentence are exactly as they appear in the popular press & do not necessarily reflect the opinions or recommendations of CDC.
• Free registration required for some articles.

Genome-wide association studies of quantitative traits with related individuals:  little (power) lost but much to be gained
Visscher PM, et al.
Eur J Hum Genet 2008 Jan

Genetics of familial amyotrophic lateral sclerosis
Valdmanis PN & Rouleau GA
Neurology 2008 Jan;70(2):144-52

Mechanisms of inherited cancer susceptibility
Hodgson S
J Zhejiang Univ Sci B 2008 Jan;9(1):1-4

Correction of population stratification in large multi-ethnic association studies
Serre D, et al.
PLoS ONE 2008;3(1):e1382

A review of gene-drug interactions for nonsteroidal anti-inflammatory drug use in preventing colorectal neoplasia
Cross JT, et al.
Pharmacogenomics J 2008 Jan

Predictors of Contralateral Prophylactic Mastectomy in Women With a BRCA1 or BRCA2 Mutation: The Hereditary Breast Cancer Clinical Study Group
Metcalfe KA, et al.
J Clin Oncol 2008 Jan

A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples
Sebastiani P, et al.
BMC Genet 2008 Jan;9(1):6

The Environmental Polymorphisms Registry: a DNA resource to study genetic susceptibility loci
Chulada PC, et al.
Hum Genet 2008 Jan

The genetics of nicotine addiction liability: ethical and social policy implications
Hall WD, et al.
Addiction 2008 Jan

Ethical issues raised by incorporation of genetics into the National Birth Defects Prevention Study
Jenkins MM, et al.
Am J Med Genet C Semin Med Genet 2008 Jan

Apolipoprotein E gene polymorphism and myocardial infarction
Kolovou GD, et al.
Int J Cardiol 2008 Jan

Gene polymorphisms in bladder cancer
Franekova M, et al.
Urol Oncol 2008 Jan-2008 Feb;26(1):1-8

 

Waiting for the genetic revolution
Kamerow D.
BMJ. 2008 Jan 5; 336(7634):22

International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers
Metcalfe KA, et al.
Int J Cancer 2008 Jan

A cost-effectiveness analysis of genetic testing of the DRD2 Taq1A polymorphism to aid treatment choice for smoking cessation
Welton NJ, et al.
Nicotine Tob Res 2008 Jan;10(1):231-40

Genetic background of celiac disease and its clinical implications
Wolters VM & Wijmenga C
Am J Gastroenterol 2008 Jan;103(1):190-5

 

How family history and risk factors for hypertension relate to ambulatory blood pressure in healthy adults
Goldstein IB, et al.
J Hypertens 2008 Feb;26(2):276-83

Family history of cancer in Brazil: is it being used?
Viana DV, et al.
Fam Cancer 2008 Jan

Variability in Adaptive Behavior in Autism: Evidence for the Importance of Family History
Mazefsky CA, et al.
J Abnorm Child Psychol 2008 Jan

"Are You at Risk for Hereditary Breast Cancer?"
Cohn WF, et al.
J Genet Couns 2008 Jan

Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending January 16, 2008, there are HuGE articles in the following areas:

Gene Variant Frequency
Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Symptoms, Signs, and Ill-defined Conditions
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page