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 Thursday, May 18, 2006     Volume 16   Number 20  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
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Coverage and Reimbursement of Genetic Tests and Services you will need a free Acrobat reader to view this file
Report of the Secretary's Advisory Committee on Genetics, Health and Society ~ February 2006

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CDC Announcements
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CDC's 2006 National Health Promotion Conference
September 12-14, 2006 ~ Atlanta, GA
A joint conference presented by CDC’s Coordinating Center for Health Promotion (CoCHP) as related to birth defects and developmental disabilities, chronic disease, and genomics. Registration is now open.

   
CDC sponsored material New HuGE Review
The epidemiology of medium chain acyl-CoA dehydrogenase deficiency: An update you will need a free Acrobat reader to view this file (111KB)
Scott Grosse et al. Genetics in Medicine (April 2006)
   
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Integrating the Evidence on Gene-Disease Association:Methods and applications of HuGE systematic reviewsThis reference links to a non-governmental website 
November 6-8, 2006 ~ Cambridge, UK
Apply now, space is limited.
 
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Tracking the Epidemiology of Human Genes in the Literature: The HuGE Published Literature DatabaseThis reference links to a non-governmental website 
Lin, B. et al. American Journal of Epidemiology

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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“K55R polymorphism gene variation linked to coronary heart disease”This reference links to a non-governmental website
(May 12) News-Medical.Net reports, “New research at the National Institute of Environmental Health Sciences, part of the National Institutes of Health, found that a common genetic variation makes some people more susceptible to coronary heart disease (CHD).”

“Hospital holds gene therapy trial”This reference links to a non-governmental website
(May 18) BBC News reports, “Gene therapy trials are to begin at Belfast City Hospital in the next few weeks - thought to be the first time it has been used in Northern Ireland.”

“Advisory panel unveils guidelines for research on GM organisms”This reference links to a non-governmental website
(May 18) Singapore News reports, “Researchers working on genetically modified organisms in Singapore now have a common set of guidelines to adhere to.”

“Newly discovered gene MCPIP may lead to treatments for preventing inflammation that cause heart disease”This reference links to a non-governmental website
(May 17) News-Medical.Net reports, “A newly discovered gene known as MCPIP could provide scientists with the key to developing treatments for preventing inflammation that can cause heart disease, University of Central Florida researchers have discovered.”

“Search for gene search for sporadic amyotrophic lateral sclerosis”This reference links to a non-governmental website
(May 17) News-Medical.Net reports, “Though it's the more common form of the disease, sporadic Amyotrophic Lateral Sclerosis (ALS), which affects roughly 90 percent of those living with the fatal neurodegenerative illness, has been the one less studied, simply because, unlike familial ALS, no genes have turned up.”

“Genetic cause of hearing loss in aging”This reference links to a non-governmental website
(May 17) News-Medical.Net reports, “Researchers at Indiana University School of Medicine have taken a step toward understanding the genetics that make people more susceptible to the loss of hearing as they age.”

“Gene family of potential tumor inhibitors identified”This reference links to a non-governmental website
(May 17) News-Medical.Net reports, “Proteins from a newly discovered family of genes, LRIG, function as a retardant for a protein that is important to tumor cells. It is probably this mechanism that lends the gene family its inhibiting effect on cancer tumors.”

“Manchester plays host to international genetics network”This reference links to a non-governmental website
(May 16) EurekAlert! reports, “Manchester is hosting an international conference on genetic counselling, with 75 delegates from professional organizations, universities and clinics all over the world, including countries such as France, Italy, India, Japan, Australia, South Africa, Canada, Cuba and the US.”

“Scientists Discover Stomach Cancer Gene”This reference links to a non-governmental website
(May 16) The Korea Times reports, “A team of South Korean scientists claimed Tuesday that they have discovered a gene triggering the proliferation of gastric cancer, a revelation that may lead to the treatment of the illness.”

“Genomics of human pathogenic fungi and bacteria”This reference links to a non-governmental website
(May 16) eitb reports, “The Navarre researcher's work has meant an advance in the race to identify action targets for developing pharmaceutical medicines to combat such infections.”

“The Molecular Post Office Inside the Cell”This reference links to a non-governmental website
(May 15) Science Daily reports, “For most proteins, there is a particular place inside a cell where they carry out their function.”

“Variant gene linked to type 1 diabetes”
(May 15) Reuters reports, “Researchers have identified a variation in a gene that is associated with type 1 diabetes, the form of the disease in which insulin production by the pancreas is deficient.”

“Tests offer hope in face of deadly genetic condition” This reference links to a non-governmental website
(May 15) The New Zealand Herald reports, “Deanne Corps has lost her son and her mother to a rare disease that may also have taken her brother.”

“British woman pregnant with cancer-gene-free 'designer baby”This reference links to a non-governmental website (last accessed 2/2008)
(May 14) The China Post reports, “A British woman has become the first in the country to conceive a "designer baby" selected specifically to avoid an inherited cancer, The Times said Saturday.”

“Fidel Castro Addresses Genetics Conference”
(May 12) Cuban News Agency reports, “Cuban President Fidel Castro gave the closing speech at the First International Congress on Community Genetics, held over the past five days in Havana.”

“Discovery of two gene variants associated with increased risk for early heart attack”This reference links to a non-governmental website
(May 12) News-Medical.Net reports, “Scientists at University of California - San Francisco (UCSF), Celera Genomics and The Cleveland Clinic have discovered two gene variants associated with a significantly increased risk for early heart attack, or myocardial infarction (MI).”

“Genes' Role in Cancer May Be Overestimated”
(May 11) Healthfinder.gov reports, “Looking for genes that could boost a person's general risk for cancer is not likely to reap great rewards, new research concludes.”

“It's in the genes: Hospitals add genetic counseling”This reference links to a non-governmental website
(May 11) St. Louis Business Journal reports, “For families with a history of cancer, genetic counseling can change lives -- or maybe save them.”

“C-myc required by the immune system”This reference links to a non-governmental website
(May 11) EurekAlert! reports, “Lausanne – c-myc, a gene commonly involved in cancer onset, has been found to have a role in the immune system's normal function according to a study published today in Blood.”

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Genomics in Scientific Literature
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Bayesian meta-analysis and meta-regression for gene-disease associations and deviations from Hardy-Weinberg equilibrium
Salanti G, et al.
Stat Med 2006 May

A two-stage design for multiple testing in large-scale association studies
Wen SH, et al.
J Hum Genet 2006 May

Gene-gene, gene-environment & multiple interactions in colorectal cancer
Ahmed FE
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2006;24(1):1-101

LRTae: improving statistical power for genetic association with case/control data when phenotype and/or genotype misclassification errors are present
Barral S, et al.
BMC Genet 2006 Apr;7(1):24

Gene polymorphism association studies in dialysis: bone and mineral metabolism
Erturk S
Semin Dial 2006 May-2006 Jun;19(3):232-7

Gene polymorphism association studies in dialysis: anemia and host immunity
Girndt M, et al.
Semin Dial 2006 May-2006 Jun;19(3):227-31

Frequency of Gastrointestinal Symptoms in Children with Autistic Spectrum Disorders and Association with Family History of Autoimmune Disease
Valicenti-McDermott M, et al.
J Dev Behav Pediatr 2006 Apr;27(2 Suppl 2):S128-S136

Genetic diagnosis of haemophilia and other inherited bleeding disorders
Peyvandi F, et al.
Haemophilia 2006 Jul;12 Suppl 3:82-9

Pharmacogenetics approach to therapeutics
Koo SH & Lee EJ
Clin Exp Pharmacol Physiol 2006 May-2006 Jun;33(5-6):525-32

Outcome after radical prostatectomy in young men with or without a family history of prostate cancer
Roupret M, et al.
Urology 2006 May;67(5):1028-32

Role of PTPN22 in type 1 diabetes and other autoimmune diseases
Bottini N, et al.
Semin Immunol 2006 May

Disparities in genetic testing: thinking outside the BRCA box
Hall MJ & Olopade OI
J Clin Oncol 2006 May;24(14):2197-203

Population screening for single genes that codetermine common diseases in adulthood had limited effects
Lamberts SW, et al.
J Clin Epidemiol 2006 Apr;59(4):358-64

PSORS1: Linking Genetics and Immunology
Elder JT
J Invest Dermatol 2006 Jun;126(6):1205-6

Uptake rates for breast cancer genetic testing: a systematic review
Ropka ME, et al.
Cancer Epidemiol Biomarkers Prev 2006 May;15(5):840-55

           
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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending May 17, 2006, there are HuGE articles in the following areas:

Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Diseases of the Blood and Blood-Forming Organs Disorders
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Complications of Pregnancy, Childbirth, and the Puerperium
Diseases of the Skin and Subcutaneous Tissue
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New this week Functional Genomics of Critical Illness and Injury This reference links to a non-governmental website
November 13-14, 2006 ~ Bethesda, Maryland
  Genomics in Public Health: 4th International DNA Sampling Conference This reference links to a non-governmental website
June 4-7, 2006 ~ Montreal, Canada
   
New this week Beyond Genome 2006This reference links to a non-governmental website
June 19-23, 2006 ~ San Francisco, CA
   
New this week 2006 Statistical Science Awards Ceremony with invited speaker Dr. Raymond J. Carroll
June 23, 2006 ~ Atlanta, Georgia
   
  The National Fragile X Foundation 10th International Fragile X Conference This reference links to a non-governmental website
July 19-23, 2006 ~ Atlanta, Georgia
   
New this week 9th Annual Conference on Computational GenomicsThis reference links to a non-governmental website
October 28-31, 2006 ~ Baltimore, Maryland
   
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Let's Go Surfing
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Newborn Screening Act Sheets and Confirmatory Algorithms This reference links to a non-governmental website
This table compiled by the American College of Medical Genetics describes the interrelationships between the conditions screened in newborn screening laboratories and the markers (analytes) used for screening.

Collaboration Education and Test Translation Program (CETT)This reference links to a non-governmental website
The CETT Program for Rare Genetic Diseases was developed by the NIH Office of Rare Diseases. (last accessed 01/2008)

Public Health Genetics/Genomics Certificate ProgramThis reference links to a non-governmental website
Sarah Lawrence College – for three decades a leader in Genetic Counseling and Health Advocacy master’s programs – is offering a new Public Health Genetics/Genomics (PHG) Certificate Program aimed at healthcare professionals who seek career change and advancement.

UK Public Health Genetics Unit Epidemiological critique - 10 May 2006This reference links to a non-governmental website
A critique of: Amundadottir LT et al.. A common variant associated with prostate cancer in European and African populations. Nature Genetics published online: 7 May 2006

 

 

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 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: May 18, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics