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 Thursday, March 30, 2006     Volume 16   Number 13  
Genomics & Health Weekly Update Genomics & Health Weekly Update Family History Genomics & Health Weekly Update Family History Population Research Genomics in Practice General Public
 This weekly update provides information about the impact of human genetic research on disease prevention  and public health.
Spotlight
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CDC Public Health Genomics Collaboration

CDC’s Public Health Genomics Collaboration
March 17, 2006

CDC’s Office of Genomics and Disease Prevention conducted an inaugural meeting to discuss the Public Health Genomics Collaboration—a new network of CDC professionals working or interested in public health genomics. The full agenda and PowerPoint presentations are now available.

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CDC Announcements
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(March, 2006) HuGENet™ releases the first edition of the HuGENet™ Handbook of Systematic Reviews. This reference links to a non-governmental website Link here to download free  Adobe Reader (167KB) This document has extensive guidance for integrating evidence on gene-disease associations, types of systematic reviews and complete set of points to consider for conducting such reviews.

 
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New HuGE Review
The long QT syndrome family of cardiac ion channelopathies
Modell, Stephen M. MD, MS; Lehmann, Michael H. MD

 
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New HuGE Review
Association between the Transforming Growth Factor Alpha Gene and Nonsyndromic Oral Clefts

   
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Quantifying the health benefits of genetic tests: The importance of a population perspective
Khoury MJ, Jones K, Grosse SD. Genet Med. (March 2006)
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Genomics In The News
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  • The following are headlines from on-line news articles published during the past week.
  • The headlines and lead sentence are exactly as they appear in the popular press and do not necessarily reflect the opinions or recommendations of CDC.
  • Free registration required for some articles.
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“Discovery of a gene that drives anthrax bacteria's toxic effects” This reference links to a non-governmental website
(March 28) News Medical.net reports, “A study in Cell reports the discovery of a gene that drives anthrax bacteria's toxic effects. The gene could offer a potential new target for countermeasures against the lethal toxin, according to the researchers.”

“Genetic Links to Mysterious Shoulder Ailment Explored: Presented at AAOS” This reference links to a non-governmental website
(March 28) Doctor’s Guide reports, “A small study that explored the theory that genetic variations in individuals may give rise to the mysterious condition known as idiopathic adhesive capsulitis was described here at the 2006 annual meeting of the American Academy of Orthopedic Surgeons (AAOS).”

“UW Scientists Unravel Genetic Puzzle for Flu Virus Replication” This reference links to a non-governmental website
(March 28) eMaxHealth reports, “Like any other organism, an influenza virus's success in life is measured by its genetic track record, its ability to pass on genes from one generation to the next.”

“Duke News Feature: Genes and Environment Interact To Promote Cancer” This reference links to a non-governmental website
(March 28) dukemed news reports, “In the granite-rich region of Western North Carolina, taking a daily shower could pose a risk of developing lung cancer.”

“One more weapon in war on cystic fibrosis Bill would add disease to screening program for
infants”
This reference links to a non-governmental website
(March 27) SFGate.com reports, “Kristi Dobson thought maybe she was being an overprotective, first-time mother when she kept taking daughter Amanda to doctors because of respiratory problems.”

“Genetic link to arsenic-related disease found”This reference links to a non-governmental website
(March 27) SciDevNet reports, “People's genes could help determine how likely they are to become ill after being exposed to arsenic, according to research in the current issue of the International Journal of Cancer.”

“Gene therapy treatment for brain tumours and infections”This reference links to a non-governmental website
(March 27) News Medical.net reports, “In a study published in the March 15 issue of The Journal of Immunology, researchers at Board of Governors' Gene Therapeutics Research Institute at Cedars-Sinai Medical Center have developed a way to overcome immune privilege in the brain to eradicate potentially deadly brain tumors such as glioblastoma multiforme and other types of brain infections.”

“Genetics Accounts for More Than Half of Anorexia Liability”This reference links to a non-governmental website
(March 27) eMaxHealth reports, “A new study led by University of North Carolina at Chapel Hill researchers estimates that 56 percent of the liability for developing anorexia nervosa is determined by genetics.”

“Public Education Key To Reducing Genetic Diseases Linked To Close Kin Marriage”This reference links to a non-governmental website
(March 27) Medical News Today reports, “Basic information on the genetic problems linked to close-kin marriage and the preventive measures available should be included as part of the secondary school curricula in the Middle East, state the authors of a Comment in this week's issue of The Lancet.”

“Mammograms safe for women with gene vulnerability: Study”This reference links to a non-governmental website (last accessed 3/2007)
(March 23) Zeenews.com reports, “X-ray screenings designed to give early warning of breast cancer do not endanger women who have genetic mutations which make them more vulnerable to the disease, a study says.”

“X factor affects belly fat and heart disease”This reference links to a non-governmental website
(March 23) myDNA reports, “Two risk factors that place males at greater risk for heart disease than women appear to be influenced by genes on the X chromosome, according to researchers at the National Institutes of Health (NIH) in Bethesda, Md., and the University of Texas Southwestern Medical School in Dallas.”

“Dimming cancer cells”This reference links to a non-governmental website
(March 23) myDNA reports, “Researchers at The Ohio State University have discovered that a natural chemical process that usually turns off gene activity can sometimes work like a dimmer switch and simply turn down the activity instead.”

“eGene's Rapid DNA Analyzer Can Identify Avian Flu Virus in Minutes; Use of System Worldwide Could Help Contain Spread”This reference links to a non-governmental website
(March 23) Genetic Engineering News reports, “eGene Inc. (OTCBB:EGEI), developers of a revolutionary high-performance genetic analysis technology, today said that if put into use at airports, borders and points of entry, its portable HDA-GT12(TM) Genetic Analyzers would have the ability to evaluate amplified DNA samples for genetic signatures of avian flu in less than 10 minutes and help halt the spread of the illness.”

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Genomics in Scientific Literature
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Reliability of self-reported ancestry among siblings: implications for genetic association studies
Burnett MS, et al.
Am J Epidemiol 2006 Mar;163(5):486-92

What race and ethnicity measure in pharmacologic research
Doyle JM
J Clin Pharmacol 2006 Apr;46(4):401-4

Common genetic vulnerability to depressive symptoms and coronary artery disease: a review and development of candidate genes related to inflammation and serotonin
McCaffery JM, et al.
Psychosom Med 2006 Mar-2006 Apr;68(2):187-200

Assumption-Free Estimation of Heritability from Genome-Wide Identity-by-Descent Sharing between Full Siblings
Visscher PM, et al.
PLoS Genet 2006 Mar;2(3):e41

Pharmacogenetic studies of epilepsy drugs: are we there yet?
Spurr NK
Trends Genet 2006 Mar

Impact of an information booklet on satisfaction and decision-making about BRCA genetic testing
Mancini J, et al.
Eur J Cancer 2006 Mar

Expanded newborn screening of inherited metabolic disorders by tandem mass spectrometry: Clinical and laboratory aspects
Garg U & Dasouki M
Clin Biochem 2006 Mar

Vitamin D receptor polymorphisms and diseases
Valdivielso JM & Fernandez E
Clin Chim Acta 2006 Mar

DNA analysis: what and when to request?
Norbury G & Norbury CJ
Arch Dis Child 2006 Apr;91(4):357-60

SNPs3D: Candidate Gene and SNP selection for Association Studies
Yue P, et al.
BMC Bioinformatics 2006 Mar;7(1):166

False-negative factor V Leiden genetic testing in a patient with recurrent deep venous thrombosis
Libby EN, et al.
Am J Hematol 2006 Mar;81(4):284-9

Cytochrome P450 pharmacogenetics and cancer
Rodriguez-Antona C & Ingelman-Sundberg M
Oncogene 2006 Mar;25(11):1679-91

Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer
Nagar S & Remmel RP
Oncogene 2006 Mar;25(11):1659-72

N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk
Hein DW
Oncogene 2006 Mar;25(11):1649-58

Thiopurine S-methyltransferase pharmacogenetics: insights, challenges and future directions
Wang L & Weinshilboum R
Oncogene 2006 Mar;25(11):1629-38

Cyclin D1: polymorphism, aberrant splicing and cancer risk
Knudsen KE, et al.
Oncogene 2006 Mar;25(11):1620-8

Cost-effectiveness of preventive strategies for women with a BRCA1 or a BRCA2 mutation
Anderson K, et al.
Ann Intern Med 2006 Mar;144(6):397-406

The inherited genetics of pancreatic cancer and prospects for secondary screening
Vitone LJ, et al.
Best Pract Res Clin Gastroenterol 2006 Apr;20(2):253-83

Risk prediction models for familial breast cancer
Antoniou AC & Easton DF
Fut Oncol 2006 Apr;2(2):257-74

Common genetic polymorphisms and prognosis of sporadic cancers: prostate cancer as a model
Habuchi T
Fut Oncol 2006 Apr;2(2):233-45

Perform a gene test on every patient: the medical family history revisited
Bendure WB & Mulvihill JJ
J Okla State Med Assoc 2006 Feb;99(2):78-83

Family history of gastric cancer: a correlation between epidemiologic findings and clinical data
Bernini M, et al.
Gastric Cancer 2006;9(1):9-13

The Impact of Missing and Erroneous Genotypes on Tagging SNP Selection and Power of Subsequent Association Tests
Liu W, et al.
Hum Hered 2006 Mar;61(1):31-44

A design for cancer case-control studies using only incident cases: experience with the GEM study of melanoma
Begg CB, et al.
Int J Epidemiol 2006 Mar

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HuGE Published Literature
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Articles that report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests. For more information on HuGE, please visit the HuGENet™ home page

For the week ending March 29, 2006, there are HuGE articles in the following areas:

Infectious and Parasitic Diseases
Neoplasms
Endocrine, Nutritional and Metabolic Diseases
Mental Disorders
Diseases of the Nervous System and Sense Organs
Diseases of the Circulatory System
Diseases of the Respiratory System
Diseases of the Digestive System
Diseases of the Genitourinary System
Diseases of the Musculoskeletal System and Connective Tissue
Congenital Anomalies
Symptoms, Signs, and Ill-defined Condition
Injury and Poisoning

For more information on HuGE, please visit the HuGENet™ home page

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Upcoming Events
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New this week

Nutrigenomics and Beyond: Informing the Future  This reference links to a non-governmental website
June 1-2, 2006 ~ Washington, DC
 

Gene Expression & Singaling in the Immune System
April 26-30, 2006 ~ Cold Spring Harbor, NY

   
  9th Annual Meeting of the American Society of Gene Therapy
May 31 - June 4, 2006 ~ Baltimore, MD
   
Genomics in Public Health: 4th International DNA Sampling Conference This reference links to a non-governmental website (last accessed 3/2007)
June 4-7, 2006 ~ Montreal, Canada
   
  11th International Congress of Human GeneticsThis reference links to a non-governmental website
August 6-10, 2006 ~ Brisbane, Australia
   
New this week Genomes, Medicine, and the Environment ConferenceThis reference links to a non-governmental website (last accessed 3/2007)
October 16-18, 2006 ~ Hilton Head, SC
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Let's Go Surfing
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Secretary’s Advisory Committee on Genetics, Health, and Society Report on Coverage and Reimbursement of Genetic Tests and Services Link here to download free  Adobe Reader (851KB) This reference links to a non-governmental website (last accessed 3/2007)
February 2006

Oregon Department of Human Services Health Services Employment Opportunity
Team Lead (Principle Contributor) position

From Genetics to Genomics For TeachersThis reference links to a non-governmental website
This tool for teachers will explore family history, multifactorial traits and genetic variations.

Genomics and Population Health Conference SummaryThis reference links to a non-governmental website
Leading experts in genetics and public health came together to call for a joint approach to the challenge of using new knowledge and technologies from the Human Genome Project to benefit population health.

 

 

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The CDC Office of Genomics and Disease Prevention makes available the above information as a public service only. Providing
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This reference links to a non-governmental website
 Provides link to non-governmental sites and does not necessarily represent the views of the Centers for  Disease Control and Prevention.
Page last reviewed: March 30, 2006 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics