The first edition of the HuGENet™ Handbook of Systematic Reviews is now available at the HuGENet Canada Website. This document includes information on the different types of HuGE reviews and a complete set of points to consider when conducting such reviews.

HuGENet™ publications are articles related to the HuGENet™ movement written by HuGENet™ collaborators. A number of new HuGENet™ publications have been added to our website in February:

• Expanded publishing model for genetic association studies.
  Gwinn M, Khoury MJ. Epidemiol Biomarkers Prev 2006;15(1):185.

• Journals should publish all "null" results and should sparingly publish "positive" results.
  Ioannidis JP. Cancer Epidemiol Biomarkers Prev 2006;15(1):186.

• A road map for efficient and reliable human genome epidemiology.
  Ioannidis JP, Gwinn M, Little J, Higgins JP, Bernstein JL, Boffetta P, et al. Nat Genet 2006;38(1):3-5.

• Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations
  Trikalinos TA, Salanti G, Khoury MJ, Ioannidis JP. Am J Epidemiol 2006;163(4):300-9.

View all HuGENet™ Publications and learn how to submit a paper

Two new HuGE Reviews have been posted on the HuGENet™ website since the last issue of ‘What's New': “NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis” by Nora Franceschini et al. from the University of North Carolina, Chapel Hill and “Association between the Transforming Growth Factor Alpha Gene and Nonsyndromic Oral Clefts: A HuGE Review” by Alexandre Vieira. These reviews will be simultaneously published in the February issue of Genetics in Medicine and the issue of the American Journal of Epidemiology, respectively.

• NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis

Two HuGE Reviews were proposed in February:

• GSTM1, CYP1A1 and smoking and lung cancer
  Gurdeep Sagoo and Julian Higgins (Public Health Genetics Unit, Cambridge, UK)

• Lipoprotein lipase gene polymorphisms and coronary heart disease
  Gurdeep Sagoo et al. (Public Health Genetics Unit, Cambridge, UK)

• Guidelines for submitting HuGE Reviews
• List of completed HuGE Reviews
• List of HuGE Review topics under development

The HuGENet™ staff has compiled a list of funding opportunities for population-based research on the prevalence of human genetic variation, the association between genetic variants and human diseases, gene-gene or gene-environment interaction, or the evaluation of genetic tests for screening and prevention.  Items are pulled from the National Institutes of Health Office of Extramural Research.  Additional information and application details can be found by clicking on the respective links.  New program announcements or requests for applications will be posted in future issues of the “What's New?” as they become available.

New listings:

• GENETIC FACTORS IN BIRTH DEFECTS (RFP-NIH-NICHD-2006-02)

As of March 1, 2006, the HuGENet™ website contains:

20,272 research studies indexed in the HuGE Published Literature database, referencing 2,252 genes, 743 factors (personal or environmental), and 2,406 health outcomes/diseases.  Both epidemiologic studies and review articles can be found in the database which includes 258 meta-analyses and 88 pooled analyses. Please see the GDPInfo Summary of Contents for more details.

Note: The count of health outcomes indexed in the database is based on a query that groups similar outcomes according to ICD-9 codes.  This figure is different from the total numbers of records listed in the Genomics and Disease Prevention Information system (GDPInfo) portal Health Topics A-Z. 

Search for specific HuGENet™ content using the Advanced Search feature in the GDPInfo query tool.

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