Prof. George P. Chrousos, MD, PhD
Professor John Ioannidis was born in New York, USA, in 1965 and graduated from Athens College in Greece as the Valedictorian of the class of 1984, the highest honour of this prestigious school. He won several awards, including first prize in the Greek National Mathematics Competition and the John Vakis Award for Natural Sciences. He graduated at the top of his class from the School of Medicine, University of Athens, Greece, in 1990. He then did his residency training in Internal Medicine at Harvard's New England Deaconess Hospital, currently Beth Israel Deaconess Medical Centre, USA. In 1993–1996, he pursued fellowship training at the Division of Infectious Diseases and the Division of Clinical Care Research at Tufts-New England Medical Centre, Boston, MA, USA. After completing his fellowship, he moved to the National Institutes of Health, in a career position at the National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA, with a joint appointment at Johns Hopkins Hospital and Johns Hopkins University School of Medicine, Baltimore, MD, USA. He has been Chairman of the Department of Hygiene and Epidemiology at the School of Medicine, University of Ioannina, Ioannina, Greece, since 1999 (as tenured Professor since 2003). He has also served in the adjunct faculty of Tufts University School of Medicine since 1996, with the rank of Professor since 2002. He is a member of the editorial board of 12 international journals, including the Lancet.
Professor Ioannidis's publication record includes approximately 300 papers, which have received over 8000 citations. His work combines skills in novel clinical research methodology and evidence-based medicine with the challenges of current molecular medicine. He has made major contributions in the following areas:
- Leading empirical research on clinical research evidence and its limitations; the concordance of various forms of evidence and small studies versus . large-scale evidence.
- Making sense of evidence in the revolution of human genomics (large-scale evidence on genetic susceptibility for complex diseases, replication validity, racial descent differences, microarray research and discovery-oriented research, human genome epidemiology network and the roadmap for human genome epidemiology).
- Evaluations of bias and credibility in research findings (time-lag bias, publication bias, reporting biases, empirical evidence on replication and contradiction of clinical research, challenges in translational medicine and modelling the credibility of research findings).
- Development and leadership of international consortia of investigators in clinical research, especially in human genomics and beyond; meta-analyses of individual participant data; prospective meta-analysis.
- Highlighting the importance of reporting and appraising harms of medical interventions (reporting of harms in clinical trials, large-scale evidence on harms and lead author of CONSORT for harms).
- Extensive applications of evidence-based medicine across a wide-range of medical specialties, including meta-analyses of randomized trials, epidemiological studies, diagnostic evaluations and prognostic factors; randomized trials in AIDS treatment, antiretroviral resistance testing, anaemia in kidney disease, autoimmune diseases and antibiotic use.
Professor John Ioannidis has been an outstanding researcher of the methodology of biomedical research. He has both broad and deep knowledge of basic and clinical bioscience and an immensely analytical and deductive mind that has helped analyse and synthesize data creatively from diverse studies. His contribution to biomedical research is both unique and major. The ESCI is proud to bestow upon him the 2007 Clinical Investigator Award.
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