Centers for Disease Control and Prevention Centers for Disease Control and Prevention CDC Home Search CDC CDC Health Topics A-Z site search
National Office of Public Health Genomics
Centers for Disease Control and Prevention
Office of Genomics and Disease Prevention
Site Search
 

HugeNet™

Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
June 12, 2008
Volume 20, No. 24

Return to Weekly Update

Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.


Gene Variant Frequency

Analysis of HLA-Cw, KIR2D genetic variations in 2 Chinese populations
Cai J, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008 Jun;25(3):343-7

 

Infectious and Parasitic Diseases

Variation in the ICAM1 gene is not associated with severe malaria phenotypes
Fry AE, et al.
Genes Immun 2008 Jun

Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans
Harris RA, et al.
Hepatology 2008 Jun

Interleukin-10 gene polymorphisms and susceptibility to brucellosis in Iranian patients
Rasouli M, et al.
Iran J Immunol 2008 Jun;5(2):131-5

HLA-DRB1, DQA1 and DQB1 Alleles and Haplotypes Frequencies in Iranian Healthy Adult Responders and Non-Responders to Recombinant Hepatitis B Vaccine
Amirzargar AA, et al.
Iran J Immunol 2008 Jun;5(2):92-9

 

Neoplasms

Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk: A replication study in an ethnically homogeneous population
Fitzgerald LM, et al.
Prostate 2008 Jun

Association of the Thr241Met polymorphism of DNA repair gene XRCC3 with genetic  susceptibility to AFB1-related hepatocellular carcinoma in Guangxi population
Long X, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008 Jun;25(3):268-71

HLA Class II Alleles and the Presence of Circulating Epstein-Barr Virus DNA in Greek Patients with Nasopharyngeal Carcinoma
Karanikiotis C, et al.
Strahlenther Onkol 2008 Jun;184(6):325-31

Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia
Dulucq S, et al.
Blood 2008 Jun

No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2  mutation carriers: a multi-center cohort study
Rebbeck TR, et al.
Breast Cancer Res Treat 2008 Jun

No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriers
Spurdle AB, et al.
Breast Cancer Res Treat 2008 Jun

Influence of Cytotoxic T Lymphocyte-associated Antigen 4 (CTLA4) Common Polymorphisms on Outcome in Treatment of Melanoma Patients With CTLA-4 Blockade
Breunis WB, et al.
J Immunother 2008 Jun

Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia  risk
Berndt SI, et al.
Hum Mol Genet 2008 Jun

Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients
Soo RA, et al.
Lung Cancer 2008 Jun

The Interleukin-8-251 A Allele is Associated With Increased Risk of Noncardia Gastric Adenocarcinoma in Helicobacter pylori-infected Koreans
Ye BD, et al.
J Clin Gastroenterol 2008 Jun

Dihydropyrimidine dehydrogenases and cytidine-deaminase gene polymorphisms as outcome predictors in resected gastric cancer patients treated with fluoropyrimidine adjuvant chemotherapy
Grau JJ, et al.
J Surg Oncol 2008 Jun

Glutathione-S-transferase M1, T1 and P1 polymorphisms, and breast cancer risk, in BRCA1/2 mutation carriers
Kadouri L, et al.
Br J Cancer 2008 Jun;98(12):2006-10

A polymorphism in a transporter of testosterone is a determinant of androgen independence in prostate cancer
Sharifi N, et al.
BJU Int 2008 Jun

Mismatch repair polymorphisms and risk of colon cancer, tumor microsatellite instability, and interactions with lifestyle factors
Campbell PT, et al.
Gut 2008 Jun

 

Endocrine, Nutritional and Metabolic Diseases

Prognostic Value of the Insertion/Deletion polymorphism of Angiotensin I Converting Enzyme gene in type 2 diabetic subjects: results from the DIABHYCAR, DIAB2NEPHROGENE & SURDIAGENE studies
Hadjadj S, et al.
Diabetes Care 2008 Jun

Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic syndrome  in men in a large Japanese cohort
Kuzuya M, et al.
Am J Clin Nutr 2008 Jun;87(6):1939-44

CYP3A4*1G polymorphism is associated with lipid-lowering efficacy of atorvastatin but not of simvastatin
Gao Y, et al.
Eur J Clin Pharmacol 2008 Jun

Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity
Sookoian S, et al.
Am J Clin Nutr 2008 Jun;87(6):1606-15

Peroxisome proliferator-activated receptor
Volcik KA, et al.
Am J Clin Nutr 2008 Jun;87(6):1926-31

Endothelial nitric oxide synthase (eNOS) gene polymorphisms and their association with type 2 diabetes-related traits in Mexican Americans
Thameem F, et al.
Diab Vasc Dis Res 2008 Jun;5(2):109-13

Clinical and genetic risk factors of self-reported penicillin allergy
Apter AJ, et al.
J Allergy Clin Immunol 2008 Jun

 

Diseases of the Blood & Blood-Forming Organ Disorders

Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement
Wang D, et al.
Blood 2008 Jun

VKORC1 and CYP2C9 polymorphisms are associated with warfarin dose requirements in Turkish patients
Oner Ozgon G, et al.
Eur J Clin Pharmacol 2008 Jun

 

Mental Disorders

Functional Polymorphism of the Human Multidrug Resistance Gene (MDR1) and Polydipsia-Hyponatremia in Schizophrenia
Shinkai T, et al.
Neuromolecular Med 2008 Jun

Association between depression and the Gln460Arg polymorphism of P2RX7 Gene: A dimensional approach
Hejjas K, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jun

Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study
Gimeno D, et al.
Psychol Med 2008 Jun:1-11

Genetic variation in the DAOA gene complex: Impact on susceptibility for schizophrenia and on cognitive performance
Opgen-Rhein C, et al.
Schizophr Res 2008 Jun

Gene-Gene Interactions Among CHRNA4, CHRNB2, BDNF, and NTRK2 in Nicotine Dependence
Li MD, et al.
Biol Psychiatry 2008 Jun

Effects of Opioid Receptor Gene Variation on Targeted Nalmefene Treatment in Heavy Drinkers
Arias AJ, et al.
Alcohol Clin Exp Res 2008 Jun

Sexually dimorphic effect of catechol-O-methyltransferase val158met polymorphism  on clinical response to fluoxetine in major depressive patients
Tsai SJ, et al.
J Affect Disord 2008 Jun

Emotional symptoms in children: The effect of maternal depression, life events, and COMT genotype
Evans J, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jun

The role of 5-HTTLPR polymorphism in antidepressant-associated mania in bipolar disorder
Ferreira AD, et al.
J Affect Disord 2008 Jun

Association Study of Theta EEG Asymmetry and Brain-derived Neurotrophic Factor Gene Variants in Childhood-onset Mood Disorder
Bulgin NL, et al.
Neuromolecular Med 2008 Jun

Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans
Mangold JE, et al.
J Med Genet 2008 Jun

 

Diseases of the Nervous System and Sense Organs

Involvement of ApoE E4 and H63D in Sporadic Alzheimer's Disease in a Folate-Supplemented Ontario Population
Percy M, et al.
J Alzheimers Dis 2008 Jul;14(1):69-84

Genetic heterogeneity and minor CYP1B1 involvement in the molecular basis of primary congenital glaucoma in Gypsies
Sivadorai P, et al.
Clin Genet 2008 Jun

Racial Differences in the Influence of the APOE Epsilon 4 Allele on Cognitive Decline in a Sample of Community-Dwelling Older Adults
Sawyer K, et al.
Gerontology 2008 Jun

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
Healy DG, et al.
Lancet Neurol 2008 Jun

Susceptibility to chronic inflammatory demyelinating polyradiculoneuropathy is associated to polymorphic GA repeat in the SH2D2A gene
Notturno F, et al.
J Neuroimmunol 2008 Jun

The Nonsynonymous Thr105Ile Polymorphism of the Histamine N-Methyltransferase is  Associated to the Risk of Developing Essential Tremor
Ledesma MC, et al.
Neuromolecular Med 2008 Jun

Inflammation, Complement Factor H, and Age-Related Macular Degeneration The Multi-Ethnic Study of Atherosclerosis
Klein R, et al.
Ophthalmology 2008 Jun

Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline
Payton A, et al.
Neurobiol Aging 2008 Jun

LRRK2 mutation in familial Parkinson's disease in a Taiwanese population: clinical, PET, and functional studies
Lin CH, et al.
J Biomed Sci 2008 Jun

LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson's disease compared to late-onset patients
Chan DK, et al.
J Neural Transm 2008 Jun

Association of two polymorphisms in ubiquitin carboxy-terminal hydrolase-L1 gene with Parkinsonos disease in Shanghai
Hao Y, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008 Jun;25(3):272-5

The NEI/NCBI dbGAP database: genotypes and haplotypes that may predispose to risk of neovascular age-related macular degeneration
Zhang H, et al.
BMC Med Genet 2008 Jun;9(1):51

LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: a case-control  genetic study
Hulihan MM, et al.
Lancet Neurol 2008 Jun

 

Diseases of the Circulatory System

Genome-wide association study for renal traits in the Framingham Heart and Atherosclerosis Risk in Communities Studies
Kottgen A, et al.
BMC Med Genet 2008 Jun;9(1):49

The association of IL-2 promoter polymorphisms with idiopathic dilated cardiomyopathy in Chinese Han population.
Huang P, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008 Jun;25(3):322-5

Common beta-adrenergic receptor polymorphisms are not associated with risk of sudden cardiac death in patients with coronary artery disease
Tseng ZH, et al.
Heart Rhythm 2008 Jun;5(6):814-21

Factor XIII Val34Leu polymorphism and the risk of myocardial infarction under the age of 36 years
Rallidis LS, et al.
Thromb Haemost 2008 Jun;99(6):1085-9

Soluble P-Selectin, SELP Polymorphisms, and Atherosclerotic Risk in European-American and African-African Young Adults. The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Reiner AP, et al.
Arterioscler Thromb Vasc Biol 2008 Jun

The associated study on apolipoprotein A5 gene polymorphisms with carotid artherosclerosis in patients with cerebral infartion.
Zhang K, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008 Jun;25(3):284-8

Abdominal obesity and hyperglycemia mask the effect of a common APOC3 haplotype on the risk of myocardial infarction
Ruiz-Narvaez EA, et al.
Am J Clin Nutr 2008 Jun;87(6):1932-8

Association of loss-of-function mutations in the ABCA1 gene with high-density lipoprotein cholesterol levels and risk of ischemic heart disease
Frikke-Schmidt R, et al.
JAMA 2008 Jun;299(21):2524-32

Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program
Ehret GB, et al.
Eur J Hum Genet 2008 Jun

Genetic analysis of the soluble epoxide hydrolase gene, EPHX2, in subclinical cardiovascular disease in the Diabetes Heart Study
Burdon KP, et al.
Diab Vasc Dis Res 2008 Jun;5(2):128-34

Study on the association between polymorphisms in angiotensinogen gene and deep  venous thrombosis.
Zhang H, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008 Jun;25(3):300-3

 

Diseases of the Respiratory System

Ozone exposure, antioxidant genes, and lung function in an elderly cohort: VA Normative Aging Study
Alexeeff SE, et al.
Occup Environ Med 2008 Jun

Cytokine gene polymorphisms and cytokine levels in pulmonary tuberculosis
Selvaraj P, et al.
Cytokine 2008 Jun

An African-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity
Seibold MA, et al.
Hum Mol Genet 2008 Jun

Transient tachypnea of the newborn (TTN): A role for polymorphisms in the beta-adrenergic receptor (ADRB) encoding genes?
Aslan E, et al.
Acta Paediatr 2008 Jun

 

Diseases of the Digestive System

Study of the Association Between Polymorphisms of the COL1A1 Gene and HBV-Related Liver Cirrhosis in Chinese Patients
Zhao YP, et al.
Dig Dis Sci 2008 Jun

Genetic Risk Factors in Young Patients With Ischemic Colitis
Theodoropoulou A, et al.
Clin Gastroenterol Hepatol 2008 Jun

IL1B+3954 SNP and red complex periodontopathogens independently and additively modulate the levels of IL-1{beta} in diseased periodontal tissues
Ferreira SB Jr, et al.
Infect Immun 2008 Jun

 

Diseases of the Genitourinary System

Exclusion of polymorphisms in carnosinase genes (CNDP1 & CNDP2) as cause of diabetic nephropathy in type 1 diabetes mellitus. Results of large case - control and follow - up studies
Wanic K, et al.
Diabetes 2008 Jun

Low prevalence of NPHS2 mutations in African American children with steroid-resistant nephrotic syndrome
Chernin G, et al.
Pediatr Nephrol 2008 Jun

Study on the association of SNPs of MMP-2 and TIMP-2 genes with the risk of endometriosis and adenomyosis.
Zhao X, et al.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008 Jun;25(3):280-3

The association of 4a4b polymorphism of endothelial nitric oxide synthase (eNOS)  gene with the sperm morphology in Korean infertile men
Yun YJ, et al.
Fertil Steril 2008 Jun

 

Complications of Pregnancy, Childbirth, and the Puerperium

Racial disparity in maternal-fetal genetic epistasis in spontaneous preterm birth
Fortunato SJ, et al.
Am J Obstet Gynecol 2008 Jun;198(6):666.e1-9;discussion 666.e9-10

 

Diseases of the Skin and Subcutaneous Tissue

The susceptibility to vitiligo is associated with NF-E2-related factor2 (Nrf2) gene polymorphisms: a study on Chinese Han population
Guan CP, et al.
Exp Dermatol 2008 Jun

 

Diseases of the Musculoskeletal System and Connective Tissue

Meta analysis on the association between FcgammaRIIa-R/H131 polymorphisms and systemic lupus erythematosus
Yuan H, et al.
Mol Biol Rep 2008 Jun

Tristetraprolin (TTP) gene polymorphisms in patients with rheumatoid arthritis and healthy individuals
Suzuki T, et al.
Mod Rheumatol 2008 Jun

Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX
Hider SL, et al.
Rheumatology (Oxford) 2008 Jun

Contribution of PTPN22 1858T, TNFRII 196R and HLA-shared epitope alleles with rheumatoid factor and anti-citrullinated protein antibodies to very early rheumatoid arthritis diagnosis
Goeb V, et al.
Rheumatology (Oxford) 2008 Jun

MCP-1 -2518 A/G single nucleotide polymorphism in slovak patients with systemic sclerosis
Navratilova Z, et al.
Mediators Inflamm 2008;2008:204063

 

For more information on HuGE, please visit the HuGENet™ home page

To receive notification of this update by e-mail, please send the following message:
To: listserv@listserv.cdc.gov
Subject: (leave blank)
Message: subscribe genetics

The CDC National Office of Public Health Genomics makes available the above information as a public service only.
Providing this information does not constitute endorsement by the CDC.  Note that some links may become invalid over time.

Page last reviewed: June 12, 2008 (archived document)
Content Source: National Office of Public Health Genomics