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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
August 28, 2008
Volume 21, No. 9

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.

Gene Variant Frequency

Genetic Polymorphisms at HLA-A, -B, and -DRB1 Loci in Han Population of Xi'an City in China
Shen C, et al.
Croat Med J 2008 Aug;49(4):476-82

Main pigmentary features and melanocortin 1 receptor (MC1R) gene polymorphisms in the population of the Canary Islands
de-Misa RF, et al.
Int J Dermatol 2008 Aug;47(8):806-11

Allelic diversity of MICA gene and MICA/HLA-B haplotypic variation in a population of the Murcia region in southeastern Spain
Lucas D, et al.
Hum Immunol 2008 Aug

Genetic polymorphisms at three loci in two populations of Manipur, India
Singh MR & Singh TS
Anthropol Anz 2008 Jun;66(2):191-8

 

Infectious and Parasitic Diseases

Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population
Dhiman N, et al.
Tissue Antigens 2008 Sep;72(3):211-20

Mannose-binding lectin gene polymorphism and resistance to therapy in women with  recurrent vulvovaginal candidiasis
Donders GG, et al.
BJOG 2008 Sep;115(10):1225-31

5' Regulatory and 3' Untranslated Region Polymorphisms of Vitamin D Receptor Gene in South Indian HIV and HIV-TB Patients
Alagarasu K, et al.
J Clin Immunol 2008 Aug

 

Neoplasms

Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland
Debniak T, et al.
Eur J Cancer Prev 2008 Oct;17(5):389-91

Ethnicity determines association of p53Arg72Pro alleles with cervical cancer in China
Zheng XZ, et al.
Eur J Cancer Prev 2008 Oct;17(5):460-6

Methylenetetrahydrofolate reductase polymorphisms and susceptibility to gastric cancer in Chinese populations: a meta-analysis
Sun L, et al.
Eur J Cancer Prev 2008 Oct;17(5):446-52

Expression and Analysis of HLA-A, B and DRB1 Genes in Patients with Chronic Myelogenous Leukemia in Guangdong Area
Wei L, et al.
Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008 Aug;16(4):915-8

Differential Expression Levels of Killer Immunoglobin-like Receptor Genotype in  Patients with Hematological Malignancies between High-risk and Standard-risk Groups
Zhao XY, et al.
Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008 Aug;16(4):746-9

MLH1 -93G>A promoter polymorphism and risk of mismatch repair deficient colorectal cancer
Allan JM, et al.
Int J Cancer 2008 Aug

Vitamin D receptor polymorphisms (FokI, BsmI) and breast cancer risk: association replication in two case-control studies within French Canadian population
Sinotte M, et al.
Endocr Relat Cancer 2008 Aug

PARP-1 Val762Ala polymorphism, CagA(+) H. pylori infection and risk for gastric cancer in Han Chinese population
Zhang Q, et al.
Mol Biol Rep 2008 Aug

The Association Between the Survivin C-31G Polymorphism and Gastric Cancer Risk in a Chinese Population
Yang L, et al.
Dig Dis Sci 2008 Aug

 

Endocrine, Nutritional and Metabolic Diseases

Adiponectin gene variants are associated with insulin sensitivity in response to  dietary fat consumption in caucasian men
Perez-Martinez P, et al.
J Nutr 2008 Sep;138(9):1609-14

Lack of evidence for association of primary sclerosing cholangitis and primary biliary cirrhosis with risk alleles for Crohn's disease in Polish patients
Gaj P, et al.
BMC Med Genet 2008 Aug;9(1):81

Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with non-alcoholic fatty liver disease in China
Lu H, et al.
J Gastroenterol Hepatol 2008 Aug

Aldose Reductase Genotypes and Cardio-Renal Complications - A 8-year Prospective  Analysis of 1074 Type 2 Diabetic Patients
So WY, et al.
Diabetes Care 2008 Aug

Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population
Gonzalez-Sanchez JL, et al.
Diabetologia 2008 Aug

Endothelial nitric oxide synthase gene polymorphism is associated with Behcet's disease in Tunisian population
Dhifallah IB, et al.
Hum Immunol 2008 Aug

Association of Interleukin-1 gene polymorphisms with central obesity and metabolic syndrome in a coronary heart disease population
Carter KW, et al.
Hum Genet 2008 Aug

Gender Differences in the Relationship of ENPP1/PC-1 Variants to Obesity in a Turkish Population
Tanyolac S, et al.
Obesity (Silver Spring) 2008 Aug

Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles
Pascoe L, et al.
Diabetologia 2008 Aug

 

Diseases of the Blood & Blood-Forming Organ Disorders

Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children
Atkinson SH, et al.
Blood 2008 Aug

 

Mental Disorders

Association of haplotypes spanning PDZ-GEF2, LOC728637 and ACSL6 with schizophrenia in Han Chinese
Luo XJ, et al.
J Med Genet 2008 Aug

The dopamine D(4) Receptor (DRD4) gene exon III polymorphism, problematic alcohol use and novelty seeking: direct and mediated genetic effects
Ray LA, et al.
Addict Biol 2008 Aug

Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample  of 270 Irish high-density schizophrenia families
Fanous AH, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Aug

Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls
Serretti A, et al.
J Psychiatr Res 2008 Aug

 

Diseases of the Nervous System and Sense Organs

Cytokine IL-1 beta but not IL-1 alpha promoter polymorphism is associated with Alzheimer disease in a population from the Canary Islands, Spain
Deniz-Naranjo MC, et al.
Eur J Neurol 2008 Aug

Evaluation of SCN8A as a candidate gene for autosomal dominant essential tremor
Sharkey LM, et al.
Parkinsonism Relat Disord 2008 Aug

Characteristic Imprint of Single Nucleotide Polymorphisms in Multiple Sclerosis
Szolnoki Z, et al.
J Mol Neurosci 2008 Aug

The LRRK2 Arg1628Pro variant is a risk factor for Parkinson's disease in the Chinese population
Lu CS, et al.
Neurogenetics 2008 Aug

Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease
Gnjec A, et al.
J Neuroinflammation 2008 Aug;5(1):36

The HtrA1 Promoter Polymorphism, Smoking, and Age-related Macular Degeneration in Multiple Case-control Samples
Tuo J, et al.
Ophthalmology 2008 Aug

 

Diseases of the Circulatory System

Effects of Functional Polymorphisms Related to Catecholaminergic Systems on Changes in Blood Catecholamine and Cardiovascular Measures After Alcohol Ingestion in the Japanese Population
Nishimura FT, et al.
Alcohol Clin Exp Res 2008 Aug

 

Diseases of the Respiratory System

Association between angiotensin-converting enzyme gene polymorphisms and exercise performance in patients with COPD
Zhang X, et al.
Respirology 2008 Sep;13(5):683-8

Haplotype Analysis of the NADPH Oxidase p22 Gene in Patients with Bronchial Asthma
Izakovicova Holla L, et al.
Int Arch Allergy Immunol 2008 Aug;148(1):73-80

Genetic interactions model among Eotaxin gene polymorphisms in asthma
Lee JH, et al.
J Hum Genet 2008 Aug

(CCTTT)n polymorphism of NOS2A in nasal polyposis and asthma: a case-control study
Pascual M, et al.
J Investig Allergol Clin Immunol 2008;18(4):239-44

Analysis of -675 4 g/5 G SERPINE1 and C-159T CD14 polymorphisms in house dust mite-allergic asthma patients
Kowal K, et al.
J Investig Allergol Clin Immunol 2008;18(4):284-92

 

Diseases of the Digestive System

The 3'UTR NFKBIA Variant Is Associated with Extensive Colitis in Hungarian IBD Patients
Szamosi T, et al.
Dig Dis Sci 2008 Aug

MAGI2 genetic variation and inflammatory bowel disease
McGovern DP, et al.
Inflamm Bowel Dis 2008 Aug

 

Complications of Pregnancy, Childbirth, and the Puerperium

Analysis of the Association of Preeclampsia with Polymorphisms of the INS, INSR and IRS1 Genes in Mexican Women
Machorro-Lazo MV, et al.
Gynecol Obstet Invest 2008 Aug;67(1):14-9

 

Diseases of the Musculoskeletal System and Connective Tissue

High mobility group box 1 (HMGB1) and macrophage migration inhibitory factor (MIF) in Kawasaki disease
Hoshina T, et al.
Scand J Rheumatol 2008 Aug:1-5

Functional Characterization of Genetic Variation in the Frizzled 1 (Fzd1) Promoter and Association with Bone Phenotypes: More to the Lrp5 Story?
Yerges LM, et al.
J Bone Miner Res 2008 Aug

THe Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism is Associated  with Spinal BMD in Nine-Year-Old Children
Steer C, et al.
J Bone Miner Res 2008 Aug

Higher LPS-stimulated TNF-alpha mRNA levels in peripheral blood mononuclear cells from Chinese ankylosing spondylitis patients with -308(G/A) polymorphism in promoter region of tumor necrosis factor: association with distinct A33/B58/Cw10  haplotypes
Lu MC, et al.
Rheumatol Int 2008 Aug

The Interleukin 23 Receptor gene does not confer risk to systemic sclerosis and is not associated with SSc disease phenotype
Rueda B, et al.|
Ann Rheum Dis 2008 Aug


Congenital Anomalies

Genomic screening identifies novel linkages and provides further evidence for a role of MYH9 in nonsyndromic cleft lip and palate
Chiquet BT, et al.
Eur J Hum Genet 2008 Aug

 

Symptoms, Signs and Ill-defined Conditions

A118G single nucleotide polymorphism of human mu-opioid receptor gene influences  pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia
Sia AT, et al.
Anesthesiology 2008 Sep;109(3):520-6

Drug-metabolising enzyme polymorphisms and predisposition to anti-tuberculosis drug-induced liver injury: a meta-analysis
Sun F, et al.
Int J Tuberc Lung Dis 2008 Sep;12(9):994-1002

Methylenetetrahydrofolate Reductase 677CT Polymorphism and Cobalamin, Folate, and Homocysteine Status in Spanish Adolescents
Al-Tahan J, et al.
Ann Nutr Metab 2008 Aug;52(4):315-21

ABCB1 polymorphisms may have a minor effect on ciclosporin blood concentrations in myasthenia gravis patients
Zhang YT, et al.
Br J Clin Pharmacol 2008 Aug;66(2):240-6

The ACTN3 R577X polymorphism in Russian endurance athletes
Ahmetov II, et al.
Br J Sports Med 2008 Aug

The influence of 5-HT(2C) and MDR1 genetic polymorphisms on antipsychotic-induced weight gain in female schizophrenic patients
Kuzman MR, et al.
Psychiatry Res 2008 Aug

 

Injury and Poisoning

Pharmacogenetics of Neonatal Opioid Toxicity Following Maternal Use of Codeine During Breastfeeding: A Case-Control Study
Madadi P, et al.
Clin Pharmacol Ther 2008 Aug

 

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Page last reviewed: August 28, 2008 (archived document)
Content Source: National Office of Public Health Genomics