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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
August 7, 2008
Volume 21, No. 6

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.

Gene Variant Frequency

TNF, IFNG, IL6, IL10 and TGFB1 gene polymorphisms in South and Southeast Brazil
Visentainer JE, et al.
Int J Immunogenet 2008 Aug

Pathogenic mitochondrial DNA mutations are common in the general population
Elliott HR, et al.
Am J Hum Genet 2008 Aug;83(2):254-60

Genetic Screening of the G2019S Mutation of the LRRK2 Gene in Southwest European, North African, and Sephardi Jew Subjects
Change N, et al.
Genet Test 2008 Jul

Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore
Lee YC, et al.
Immunogenetics 2008 Jul

[Polymorphisms in glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) in the indigenous and the nonresident population of the Kemerovo region]
Genetika 2008 Apr;44(4):539-42

 

Infectious and Parasitic Diseases

Single nucleotide polymorphisms in genes of circulatory homeostasis in surviving  pediatric intensive care patients with meningococcal infection
Bunker-Wiersma HE, et al.
Pediatr Crit Care Med 2008 Aug

Homocysteine levels and sustained virological response to pegylated-interferon alpha2b plus ribavirin therapy for chronic hepatitis C: a prospective study
Borgia G, et al.
Liver Int 2008 Jul

 

Neoplasms

CHEK2 1100delC Is a Susceptibility Allele for HNPCC-Related Colorectal Cancer
Wasielewski M, et al.
Clin Cancer Res 2008 Aug;14(15):4989-94

Genetic Polymorphisms of Metastasis Suppressor Gene NME1 and Breast Cancer Survival
Qu S, et al.
Clin Cancer Res 2008 Aug;14(15):4787-93

Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway
Hosgood HD 3rd, et al.
Carcinogenesis 2008 Aug

Investigation of an NQO1 polymorphism as a possible risk and prognostic factor for chronic lymphocytic leukemia
Begleiter A, et al.
Leuk Res 2008 Aug

Variants in inflammation genes and the risk of biliary tract cancers and stones:  a population-based study in China
Hsing AW, et al.
Cancer Res 2008 Aug;68(15):6442-52

Association of Matrix Metalloproteinases-9 Gene Polymorphisms with Genetic Susceptibility to Esophageal Squamous Cell Carcinoma
Wu J, et al.
DNA Cell Biol 2008 Aug

Investigation of CTLA-4 and CD28 gene polymorphisms in a group of Turkish patients with colorectal cancer
Dilmec F, et al.
Int J Immunogenet 2008 Aug

WRN Cys1367Arg SNP is not associated with risk and prognosis of gliomas in Southeast Brazil
Pinto GR, et al.
J Neurooncol 2008 Aug

Association of GSTM3 intron 6 variant with cigarette smoking, tobacco chewing and alcohol as modifier factors for prostate cancer risk
Kesarwani P, et al.
Arch Toxicol 2008 Jul

Associations among Lipids, Leptin, and Leptin Receptor Gene Gin223Arg Polymorphisms and Breast Cancer in China
Han CZ, et al.
Biol Trace Elem Res 2008 Jul

Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese  population
Liu H, et al.
Biomarkers 2008 Jul:1-11

UGT1A1 and UGT1A9 functional variants, meat intake, and colon cancer, among Caucasians and African-Americans
Girard H, et al.
Mutat Res 2008 Jul

Gene polymorphisms related to angiogenesis, inflammation and thrombosis that influence risk for oral cancer
Vairaktaris E, et al.
Oral Oncol 2008 Jul

Green tea intake, MTHFR/TYMS genotype, and breast cancer risk: The Singapore Chinese Health Study
Inoue M, et al.
Carcinogenesis 2008 Jul

Mitochondrial DNA Content: Its Genetic Heritability and Association With Renal Cell Carcinoma
Xing J, et al.
J Natl Cancer Inst 2008 Jul

Association of two common SNPs in the CYP19A1 locus and ovarian cancer risk
Goodman M, et al.
Endocr Relat Cancer 2008 Jul

Association of polymorphisms in base excision repair genes with the risk of breast cancer: a case-control study in North Indian women
Mitra AK, et al.
Oncol Res 2008;17(3):127-35

 

Endocrine, Nutritional and Metabolic Diseases

CHOP T/C and C/T haplotypes contribute to early-onset type 2 diabetes in Italians
Gragnoli C
J Cell Physiol 2008 Aug

Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits with 222 Candidate Genes
Gaulton KJ, et al.
Diabetes 2008 Aug

Association of KCNJ11 and ABCC8 genetic polymorphisms with response to repaglinide in Chinese diabetic patients
He YY, et al.
Acta Pharmacol Sin 2008 Aug;29(8):983-9

Novel mutations of mitochondrial DNA associated with type 2 diabetes in chinese han population
Liao WQ, et al.
Tohoku J Exp Med 2008 Aug;215(4):377-84

 

Diseases of the Blood & Blood-Forming Organ Disorders

l-selectin gene polymorphisms and complications of sickle cell disease
Ugochukwu CC, et al.
Int J Lab Hematol 2008 Aug;30(4):312-6

DNA polymorphisms at the BCL11A, HBS1L-MYB, and {beta}-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
Lettre G, et al.
Proc Natl Acad Sci U S A 2008 Jul

 

Mental Disorders

Do the estrogen receptors 1 gene variants influence the temperament and character inventory scores in suicidal attempters and healthy subjects?
Giegling I, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Aug

Apolipoprotein E {varepsilon}4 Allele Genotype and the Effect of Depressive Symptoms on the Risk of Dementia in Men: The Honolulu-Asia Aging Study
Irie F, et al.
Arch Gen Psychiatry 2008 Aug;65(8):906-12

DRD2 and ANKK1 genotype in alcohol-dependent patients with psychopathic traits: association and interaction study
Ponce G, et al.
Br J Psychiatry 2008 Aug;193(2):121-5

An association analysis of synapse-associated protein 97 (SAP97) gene in schizophrenia
Sato J, et al.
J Neural Transm 2008 Jul

Association of ADHD with genetic variants in the 5'-region of the dopamine transporter gene: Evidence for allelic heterogeneity
Brookes KJ, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Jul

Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder
Lohoff FW, et al.
J Neural Transm 2008 Jul

 

Diseases of the Nervous System and Sense Organs

A high-density association screen of 155 ion transport genes for involvement with common migraine
Nyholt DR, et al.
Hum Mol Genet 2008 Aug

Single nucleotide polymorphisms in base-excision repair genes hOGG1, APE1 and XRCC1 do not alter risk of Alzheimer's disease
Parildar-Karpuzoglu H, et al.
Neurosci Lett 2008 Jul

Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease
Schurks M, et al.
Neurology 2008 Jul

The apolipoprotein E varepsilon4 allele and memory performance in HIV-1 seropositive subjects: differences at baseline but not after acute oral lorazepam challenge
Pomara N, et al.
Psychopharmacology (Berl) 2008 Jul

Association between polymorphisms in the apolipoprotein D gene and sporadic Alzheimer's disease
Chen Y, et al.
Brain Res 2008 Jul

Association of the neuronal cell adhesion molecule (NRCAM) gene variants with autism
Marui T, et al.
Int J Neuropsychopharmacol 2008 Jul:1-10

Association between the interleukin-1beta polymorphisms and Alzheimer's disease:  A systematic review and meta-analysis
Di Bona D, et al.
Brain Res Rev 2008 Jul

 

Diseases of the Circulatory System

Effect of common KCNE1 and SCN5A ion channel gene variants on T-wave alternans, a marker of cardiac repolarization, during clinical exercise stress test: the Finnish Cardiovascular Study
Koskela J, et al.
Transl Res 2008 Aug;152(2):49-58

PROC, PROCR, and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study
Reiner AP, et al.
J Thromb Haemost 2008 Aug

Association between polymorphism of the AGTR1 and cardiovascular events in a Japanese general sample (The Shigaraki Study)
Tamaki S, et al.
Int J Cardiol 2008 Aug

The -589C>T polymorphism in the interleukin-4 gene (IL4) is associated with a reduced risk of myocardial infarction in young individuals
Paffen E, et al.
J Thromb Haemost 2008 Jul

R497K polymorphism in epidermal growth factor receptor gene is associated with the risk of acute coronary syndrome
Gao LB, et al.
BMC Med Genet 2008 Jul;9(1):74

CYP A-204C polymorphism is associated with subclinical atherosclerosis in postmenopausal women
Lambrinoudaki IV, et al.
Menopause 2008 Jul

The G79A polymorphism of protein Z gene is an independent risk factor for cerebral venous thrombosis
Le Cam-Duchez V, et al.
J Neurol 2008 Jul

Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes
Cunnington MS, et al.
Atherosclerosis 2008 Jul

Minisatellite polymorphisms of the SLC6A19: Susceptibility in hypertension
Seol SY, et al.
Biochem Biophys Res Commun 2008 Jul

 

Diseases of the Respiratory System

Beta2-adrenergic receptor haplotype and bronchodilator response to salbutamol in  patients with acute exacerbations of COPD
Mokry M, et al.
Med Sci Monit 2008 Aug;14(8):CR392-8

Surfactant protein-B polymorphisms and mortality in the acute respiratory distress syndrome
Currier PF, et al.
Crit Care Med 2008 Aug

Genetic Polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and Risk of  Silicosis in a Chinese Occupational Population
Wu F, et al.
Am J Ind Med 2008 Jul

Polymorphisms in IL12A and cockroach allergy in children with asthma
Pistiner M, et al.
Clin Mol Allergy 2008 Jul;6(1):6

The association of transforming growth factor beta 1 gene polymorphisms with the  emphysema phenotype of COPD in Japanese
Ito M, et al.
Intern Med 2008;47(15):1387-94

 

Diseases of the Digestive System

The ITGB2 immunomodulatory gene (CD18), enterocolitis, and Hirschsprung's disease
Moore SW, et al.
J Pediatr Surg 2008 Aug;43(8):1439-44

Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a  Korean population without significant gastroduodenal disease
Kim N, et al.
Helicobacter 2008 Aug;13(4):245-55

Interferon-Gamma and Interleukin-12 Gene Polymorphisms and Their Relation to Aggressive and Chronic Periodontitis and Key Periodontal Pathogens
Reichert S, et al.
J Periodontol 2008 Aug;79(8):1434-43

No association of the CD45 77C>G transversion with inflammatory bowel disease in  German patients
Thude H, et al.
Int J Immunogenet 2008 Aug

ATG16L1 T300A Shows Strong Associations With Disease Subgroups in a Large Australian IBD Population: Further Support for Significant Disease Heterogeneity
Fowler EV, et al.
Am J Gastroenterol 2008 Jul

Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease
Rigoli L, et al.
World J Gastroenterol 2008 Jul;14(28):4454-61

Cytokine gene polymorphisms in periodontal disease: a meta-analysis of 53 studies including 4178 cases and 4590 controls
Nikolopoulos GK, et al.
J Clin Periodontol 2008 Jul

Runt-related transcription factor 3 is associated with ulcerative colitis and shows epistasis with solute carrier family 22, members 4 and 5
Weersma RK, et al.
Inflamm Bowel Dis 2008 Jul

Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population: Role of serine protease inhibitor Kazal 1type and alcohol
Muddana V, et al.
World J Gastroenterol 2008 Jul;14(28):4486-91

 

Diseases of the Musculoskeletal System and Connective Tissue

The cyclic GMP-dependent protein kinase II gene associates with gout disease identified by genome-wide analysis and case-control study
Chang SJ, et al.
Ann Rheum Dis 2008 Aug

Mitochondrial DNA haplogroups: Role in the prevalence and severity of knee osteoarthritis
Rego-Perez I, et al.
Arthritis Rheum 2008 Jul;58(8):2387-96

Polymorphisms in the estrogen receptor genes are associated with hip fractures inChinese
Wang JT, et al.
Bone 2008 Jul

Type I Collagen {alpha}1 Sp1 Polymorphism and the Risk of Cruciate Ligament Ruptures or Shoulder Dislocations
Khoschnau S, et al.
Am J Sports Med 2008 Jul

 

Injury and Poisoning

Genetic susceptibility to traumatic brain injury and apolipoprotein E gene
Sun XC & Jiang Y
Chin J Traumatol 2008 Aug;11(4):247-52

 

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Page last reviewed: August 7, 2008 (archived document)
Content Source: National Office of Public Health Genomics