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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
April 10, 2008
Volume 20, No. 15

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.


Neoplasms

Caspase polymorphisms and genetic susceptibility to multiple myeloma
Hosgood HD 3rd, et al.
Hematol Oncol 2008 Apr

Single-Nucleotide Polymorphisms of DNA Damage Response Genes Are Associated with  Overall Survival in Patients with Pancreatic Cancer
Okazaki T, et al.
Clin Cancer Res 2008 Apr;14(7):2042-8

DNA polymorphisms in exon 1 and promoter of the CDH1 gene and relevant risk of transitional cell carcinoma of the urinary bladder
Ma X, et al.
BJU Int 2008 Apr

SDF-1 and CCR5 Genes Polymorphism in Patients with Head and Neck Cancer
Khademi B, et al.
Pathol Oncol Res 2008 Apr

Frequency of the CHEK2 1100delC mutation among women with breast cancer: an international study
Zhang S, et al.
Cancer Res 2008 Apr;68(7):2154-7

Profiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition
Yang H, et al.
Clin Cancer Res 2008 Apr;14(7):2236-44

Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer
Yang H, et al.
Cancer Res 2008 Apr;68(7):2530-7

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
Thorgeirsson TE, et al.
Nature 2008 Apr;452(7187):638-42

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
Amos CI, et al.
Nat Genet 2008 Apr

Genetic variation in the one-carbon transfer pathway and ovarian cancer risk
Kelemen LE, et al.
Cancer Res 2008 Apr;68(7):2498-506

Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma
Doecke J, et al.
Int J Cancer 2008 Apr

Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer
Lacko M, et al.
Head Neck 2008 Mar

Potentially functional polymorphisms of the vascular endothelial growth factor gene and risk of gastric cancer
Ke Q, et al.
Mol Carcinog 2008 Mar

Genetic variants in germline TP53 and MDM2 SNP309 are not associated with early onset colorectal cancer
Khan SA, et al.
J Surg Oncol 2008 Mar

The modifying effect of C-reactive protein gene polymorphisms on the association  between central obesity and endometrial cancer risk
Wen W, et al.
Cancer 2008 Mar

 

Endocrine, Nutritional and Metabolic Diseases

Interaction Between PPARgamma2 Variants and Gender on the Modulation of Body Weight
Morini E, et al.
Obesity (Silver Spring) 2008 Apr

INS VNTR Is Not Associated With Childhood Obesity in 1,023 Families: A Family-based Study
Bouatia-Naji N, et al.
Obesity (Silver Spring) 2008 Apr

On the Replication of Genetic Associations: Timing Can Be Everything
Lasky-Su J, et al.
Am J Hum Genet 2008 Apr

A pilot study of premature ovarian senescence: II. Different genotype and phenotype for genetic and autoimmune etiologies
Gleicher N, et al.
Fertil Steril 2008 Apr

A pilot study of premature ovarian senescence: I. Correlation of triple CGG repeats on the FMR1 gene to ovarian reserve parameters FSH and anti-Mullerian hormone
Gleicher N, et al.
Fertil Steril 2008 Apr

Exon 33 T/T genotype of the thyroglobulin gene is a susceptibility gene for Graves' disease in Taiwanese and exon 12 C/C genotype protects against it
Hsiao JY, et al.
Clin Exp Med 2008 Mar;8(1):17-21

 

Diseases of the Blood & Blood-Forming Organ Disorders

The Italian AICE-Genetics hemophilia A database: results and correlation with clinical phenotype
Margaglione M, et al.
Haematologica 2008 Apr

 

Mental Disorders

Genetic and Disorder-Specific Aspects of Resting State EEG Abnormalities in Schizophrenia
Venables NC, et al.
Schizophr Bull 2008 Apr

Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene
Kahler AK, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Apr

Social support in older individuals: The role of the BDNF Val66Met polymorphism
Taylor WD, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Apr

Association study of candidate variants of COMT with neuroticism, anxiety and depression
Wray NR, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Apr

Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder
Keck ME, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Apr

Association of candidate genes with antisocial drug dependence in adolescents
Corley RP, et al.
Drug Alcohol Depend 2008 Mar

 

Diseases of the Nervous System and Sense Organs

Association of LOXL1 Common Sequence Variants in German and Italian Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma
Pasutto F, et al.
Invest Ophthalmol Vis Sci 2008 Apr;49(4):1459-63

Lack of evidence for association of a parkin promoter polymorphism with early-onset Parkinson's disease in a Chinese population
Taylor JM, et al.
Parkinsonism Relat Disord 2008 Apr

Catechol O-methyl transferase and dopamine D2 receptor gene polymorphisms: evidence of positive heterosis and gene-gene interaction on working memory functioning
Gosso MF, et al.
Eur J Hum Genet 2008 Apr

Pharmacogenetics of parkinsonism, rigidity, rest tremor, and bradykinesia in African-Caribbean inpatients: Differences in association with dopamine and serotonin receptors
Hadithy AF, et al.
Am J Med Genet B Neuropsychiatr Genet 2008 Apr

Toll-like Receptor Polymorphisms and Age-Related Macular Degeneration
Edwards AO, et al.
Invest Ophthalmol Vis Sci 2008 Apr;49(4):1652-9

An entorhinal cortex sulcal pattern is associated with Alzheimer's disease
Zhan J, et al.
Hum Brain Mapp 2008 Apr

Association study of a functional catechol-O-methyltransferase polymorphism and executive function in elderly males without dementia
Liu ME, et al.
Neurosci Lett 2008 Mar

Absence of optineurin (OPTN) gene mutations in Taiwanese patients with juvenile-onset open-angle glaucoma
Yen YC, et al.
Mol Vis 2008;14:487-94

The role of mitochondrial haplogroups in glaucoma: a study in an Arab population
Abu-Amero KK, et al.
Mol Vis 2008;14:518-22

Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma
Aragon-Martin JA, et al.
Mol Vis 2008;14:533-41

C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated  with primary closed angle glaucoma
Michael S, et al.
Mol Vis 2008;14:661-5

 

Diseases of the Circulatory System

Temperamental Activity and Epidermal Growth Factor A61G Polymorphism in Finnish Adults
Puttonen S, et al.
Neuropsychobiology 2008 Apr;56(4):208-12

ABO blood group and risk of venous or arterial thrombosis in carriers of factor V Leiden or prothrombin G20210A polymorphisms
Minano A, et al.
Haematologica 2008 Apr

Prevalence of Thrombophilic Mutations and ACE ID Polymorphism in Turkish Ischemic Stroke Patients
Celiker G, et al.
Clin Appl Thromb Hemost 2008 Apr

Association of a CYP4A11 Variant and Blood Pressure in Black Men
Gainer JV, et al.
J Am Soc Nephrol 2008 Apr

Interleukin 8 and Susceptibility to Coronary Artery Disease: a Population Genetics Perspective
Vogiatzi K, et al.
J Clin Immunol 2008 Apr

Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD
Knowles JW, et al.
BMC Med Genet 2008 Apr;9(1):23

The K121Q polymorphism of ENPP1 and peripheral arterial disease
Eller P, et al.
Heart Vessels 2008 Mar;23(2):104-7

Methylenetetrahydrofolate reductase gene, homocysteine and coronary artery disease: The A1298C polymorphism does matter. Inferences from a case study (Madeira, Portugal)
Freitas AI, et al.
Thromb Res 2008 Mar

Effect of APOE Genotype on Lipid Levels in Patients With Coronary Heart Disease During a 3-Week Inpatient Rehabilitation Program
Vossen C, et al.
Clin Pharmacol Ther 2008 Mar

COX-2 gene promoter polymorphism and coronary artery disease in middle-aged men:  the Helsinki sudden death study
Huuskonen KH, et al.
Mediators Inflamm 2008;2008:289453

 

Diseases of the Respiratory System

Influence of beta2-adrenoceptor polymorphisms on the response to chronic use of albuterol in asthmatic children
Giubergia V, et al.
Pediatr Pulmonol 2008 May;43(5):421-5

Polymorphisms in the Type IV Collagen Alpha3 Gene and the Risk of COPD
Kim KM, et al.
Eur Respir J 2008 Apr

Functional SNPs of the CCL5 gene and non-emphysematous phenotype in patients with COPD
Hizawa N, et al.
Eur Respir J 2008 Apr

A single nucleotide polymorphism (A --> G) in intron 3 of IFNgamma gene is associated with asthma
Kumar A & Ghosh B
Genes Immun 2008 Apr

Interleukin 18 receptor 1 gene polymorphisms are associated with asthma
Zhu G, et al.
Eur J Hum Genet 2008 Apr

Systemic inflammation, genetic susceptibility and lung function
Sunyer J, et al.
Eur Respir J 2008 Apr

TNFA-308 in Two International Population-Based Cohorts Shows Increased Risk for Asthma
Castro-Giner F, et al.
Eur Respir J 2008 Apr

 

Diseases of the Digestive System

Lymphotoxin alpha LTA+496C allele is a risk factor for periodontitis in patients  with coronary artery disease
Palikhe A, et al.
Tissue Antigens 2008 Apr

Interleukin-6 Polymorphisms Are Associated With Pathogenic Bacteria in Subjects With Periodontitis
Nibali L, et al.
J Periodontol 2008 Apr;79(4):677-83

IL23R and IL12B polymorphisms in Spanish IBD patients: No evidence of interaction
Marquez A, et al.
Inflamm Bowel Dis 2008 Mar

Genetic association of interleukin-1 haplotypes with gastritis and precancerous lesions in North Indians
Achyut BR, et al.
Clin Exp Med 2008 Mar;8(1):23-9

A Genetic Variant of the CD14 C-159T in Patients with Functional Dyspepsia (FD) in Japanese Subjects
Tahara T, et al.
J Clin Biochem Nutr 2008 Mar;42(2):104-10

Investigation of associations between the pregnane-X receptor gene (NR1I2) and Crohn's disease in Canadian children using a gene-wide haplotype-based approach
Amre DK, et al.
Inflamm Bowel Dis 2008 Mar

 

Diseases of the Genitourinary System

Estrogen receptor alpha polymorphism is associated with pelvic organ prolapse risk
Chen HY, et al.
Int Urogynecol J Pelvic Floor Dysfunct 2008 Apr

 

Complications of Pregnancy, Childbirth, and the Puerperium

Interleukin-10 -1082 G/A promoter polymorphism and pregnancy complications: results of a prospective cohort study in 1,616 pregnant women
Stonek F, et al.
Acta Obstet Gynecol Scand 2008;87(4):430-3

Maternal TLR4 and NOD2 gene variants, pro-inflammatory phenotype and susceptibility to early-onset preeclampsia and HELLP syndrome
van Rijn BB, et al.
PLoS ONE 2008;3(4):e1865

 

Diseases of the Skin and Subcutaneous Tissue

EDA2R Is Associated with Androgenetic Alopecia
Prodi DA, et al.
J Invest Dermatol 2008 Apr

Mutation screening of the CARD15 gene in sarcoidosis
Akahoshi M, et al.
Tissue Antigens 2008 Apr

Association between TNFA-308 G/A polymorphism and sensitization to para-phenylenediamine: a case-control study
Blomeke B, et al.
Allergy 2008 Mar

 

Diseases of the Musculoskeletal System and Connective Tissue

Association of bone morphogenetic protein-2 gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity in Chinese patients
Wang H, et al.
Eur Spine J 2008 Apr

The TNF Receptor Superfamily member 1b 676T>G polymorphism in relation to response to infliximab and adalimumab treatment and disease severity in rheumatoid arthritis
Toonen EJ, et al.
Ann Rheum Dis 2008 Apr

Human Leukocyte Antigen and Clinical and Demographic Characteristics in Psoriatic Arthritis and Psoriasis in Chinese Patients
Liao HT, et al.
J Rheumatol 2008 Mar

Association of CD24 Gene Polymorphisms with Susceptibility to Biopsy-Proven Giant Cell Arteritis
Rueda B, et al.
J Rheumatol 2008 Mar

BAT1 Promoter Polymorphism Is Associated with Rheumatoid Arthritis Susceptibility
Quinones-Lombrana A, et al.
J Rheumatol 2008 Mar

The Functional Variant (Asp299gly) of Toll-like Receptor 4 (TLR4) Influences TLR4-Mediated Cytokine Production in Rheumatoid Arthritis
Roelofs MF, et al.
J Rheumatol 2008 Mar

Cyclooxygenase-2 Polymorphisms and Risk of Rheumatoid Arthritis in Koreans
Yun HR, et al.
J Rheumatol 2008 Mar

Single-Nucleotide Polymorphisms in CCL2 Gene Are Not Associated with Susceptibility to Systemic Sclerosis
Carulli MT, et al.
J Rheumatol 2008 Mar

HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus
Rizzo R, et al.
Tissue Antigens 2008 Mar

Association of interleukin-23 receptor variants with ankylosing spondylitis
Rahman P, et al.
Arthritis Rheum 2008 Mar;58(4):1020-5

Methotrexate (MTX) Pathway Gene Polymorphisms and Their Effects on MTX Toxicity in Caucasian and African American Patients with Rheumatoid Arthritis
Ranganathan P, et al.
J Rheumatol 2008 Mar

 

Congenital Anomalies

Nutritional and genetic determinants of vitamin B and homocysteine metabolisms in neural tube defects: A multicenter case-control study
Candito M, et al.
Am J Med Genet A 2008 Apr

 

Certain Conditions Originating in the Perinatal Period

Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome
Nonnis Marzano F, et al.
Genomics 2008 Apr

 

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Page last reviewed: April 10, 2008 (archived document)
Content Source: National Office of Public Health Genomics