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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
September 13, 2007
Volume 19, No. 11

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These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Gene Variant Frequency

Polymorphisms in CCR5 chemokine receptor gene in Japan
Liu H, et al.
Int J Immunogenet 2007 Oct;34(5):325-35

 

Infectious and Parasitic Diseases

Influences of MxA gene -88 G/T and IFN-gamma +874 A/T on the natural history of hepatitis B virus infection in an endemic area
Peng XM, et al.
Int J Immunogenet 2007 Oct;34(5):341-6

Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection
Hennig BJ, et al.
Liver Int 2007 Oct;27(8):1134-43

Polymorphisms in the IFNAR1 gene in patients with chronic hepatitis C: outcome of combined IFN-alpha therapy
Tena-Tomas C, et al.
Eur Cytokine Netw 2007 Sep;18(3):19-24

Clarithromycin Resistance, Tumor Necrosis Factor Alpha Gene Polymorphism and Mucosal Inflammation Affect H. pylori Eradication Success
Zambon CF, et al.
J Gastrointest Surg 2007 Sep

CCR5 haplotypes and mother-to-child HIV transmission in Malawi
Pedersen BR, et al.
PLoS ONE 2007;2(9):e838

 

Neoplasms

Association of polymorphisms of human leucocyte antigen-DQA1 and DQB1 alleles with chronic hepatitis B virus infection, liver cirrhosis and hepatocellular carcinoma in Chinese
Liu C & Cheng B
Int J Immunogenet 2007 Oct;34(5):373-8

Seizure 6-Like (SEZ6L) Gene and Risk for Lung Cancer
Gorlov IP, et al.
Cancer Res 2007 Sep;67(17):8406-11

Interaction of Soy Food and Tea Consumption with CYP19A1 Genetic Polymorphisms in the Development of Endometrial Cancer
Xu WH, et al.
Am J Epidemiol 2007 Sep

Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma
Cerhan JR, et al.
Blood 2007 Sep

SRD5A2 and HSD3B2 polymorphisms are associated with prostate cancer risk and aggressiveness
Neslund-Dudas C, et al.
Prostate 2007 Sep

ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel
Green H, et al.
J Pharm Sci 2007 Sep

Polymorphisms in the genes of the urokinase plasminogen activation system in relation to colorectal cancer
Forsti A, et al.
Ann Oncol 2007 Sep

Inherited variation in hormone-regulating genes and prostate cancer survival
Lindstrom S, et al.
Clin Cancer Res 2007 Sep;13(17):5156-61

Moving toward individualized therapy based on NER polymorphisms that predict platinum sensitivity in ovarian cancer patients
Saldivar JS, et al.
Gynecol Oncol 2007 Sep

Correlation of the polymorphism of HLAA, B and DRB1 alleles with nasopharyngeal  carcinoma in the south of China
Zeng XH, et al.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007 Sep;23(9):819-20

Pharmacogenetic Modulation of Combined Hormone Replacement Therapy by Progesterone-Metabolism Genotypes in Postmenopausal Breast Cancer Risk
Rebbeck T, et al.
Am J Epidemiol 2007 Sep

The hOGG1 Ser326Cys Polymorphism Is Not Associated with Colorectal Cancer Risk
Park HW, et al.
J Epidemiol 2007 Sep;17(5):156-60

Association of BRAF V600E Mutation with Poor Clinicopathologic Outcomes in 500 Consecutive Cases of Papillary Thyroid Carcinoma
Lupi C, et al.
J Clin Endocrinol Metab 2007 Sep

CXCL12 G801A Polymorphism Is a Risk Factor for Sporadic Prostate Cancer Susceptibility
Hirata H, et al.
Clin Cancer Res 2007 Sep;13(17):5056-62

A common variant associated with prostate cancer in European and African populations Amundadottir LT, Sulem P, Gudmundsson J, Helgason A, Baker A, Agnarsson BA, Sigurdsson A, Benediktsdottir KR, Cazier JB, Sainz J, Jakobsdottir  M, Kostic J,Magnusdottir
Kibel AS
Urol Oncol 2007 Sep-2007 Oct;25(5):446-7

The MTHFR 677C-->T polymorphism and risk of prostate cancer: results from the CAPS study
Johansson M, et al.
Cancer Causes Control 2007 Sep

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24 Yeager M, Orr N, Hayes RB, Jacobs KB, Kraft P, Wacholder S, Minichiello MJ, Fearnhead P, Yu K, Chatterjee N, Wang Z, Welch R, Staats BJ, Calle EE, Feigelson HS,
Kibel AS
Urol Oncol 2007 Sep-2007 Oct;25(5):447-8

Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population
Wang L, et al.
BMC Cancer 2007 Sep;7(1):173

The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk
Dai Q, et al.
Am J Clin Nutr 2007 Sep;86(3):743-51

 

Endocrine, Nutritional and Metabolic Diseases

Lack of association between the Pro(12)Ala polymorphism of the PPAR-gamma2 gene and type 2 diabetes mellitus in the Qatari consanguineous population
Badii R, et al.
Acta Diabetol 2007 Sep

The degree of external genitalia virilization in girls with 21-hydroxylase deficiency appears to be influenced by the CAG repeats in the androgen receptor gene
Rocha RO, et al.
Clin Endocrinol (Oxf) 2007 Sep

Association and linkage studies of the 20q11.2 region (GRD-2 locus) with Graves'  disease in the Tunisian population
Makni K, et al.
Ann Hum Biol 2007 Sep-2007 Oct;34(5):566-72

Identification of a PCOS Susceptibility Variant in Fibrillin-3 and Association with a Metabolic Phenotype
Urbanek M, et al.
J Clin Endocrinol Metab 2007 Sep

SNPs in the KCNJ11-ABCC8 gene locus are associated with type 2 diabetes and blood pressure levels in the Japanese population
Sakamoto Y, et al.
J Hum Genet 2007 Sep

Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS
Barber TM, et al.
Diabetologia 2007 Sep

Studies of association of variants near the HHEX, CDKN2A/B and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects validation and extension of genome-wide association studies
Grarup N, et al.
Diabetes 2007 Sep

Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed  tomography
Nemoto M, et al.
Cardiovasc Diabetol 2007 Sep;6(1):23

Studies in 3,523 Norwegians (HUNT2) and Meta-Analysis in 11,571 Subjects Indicate that Variants in the HNF4A P2 Region are Associated with Type 2 Diabetes in Scandinavians
Johansson S, et al.
Diabetes 2007 Sep

LPIN2 is associated with type 2 diabetes, glucose metabolism and body composition
Aulchenko YS, et al.
Diabetes 2007 Sep

A SEARCH FOR VARIANTS ASSOCIATED WITH YOUNG-ONSET TYPE 2 DIABETES IN AMERICAN INDIANS IN A 100K GENOTYPING ARRAY
Hanson RL, et al.
Diabetes 2007 Sep

Identification of Type 2 Diabetes Genes in Mexican Americans Through Genome-wide  Association Studies
Hayes MG, et al.
Diabetes 2007 Sep

Hemochromatosis genotypes and risk of 31 disease endpoints: Meta-analyses including 66,000 cases and 226,000 controls
Ellervik C, et al.
Hepatology 2007 Sep

Single nucleotide polymorphisms in ABCG5 and ABCG8 are associated with changes in cholesterol metabolism during weight loss
Santosa S, et al.
J Lipid Res 2007 Sep

Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: Evidence for replication from diabetes-related quantitative traits and from independent populations
Rampersaud E, et al.
Diabetes 2007 Sep

Impact of the -1438G>A polymorphism in the serotonin 2A receptor gene on anthropometric profile and obesity risk: A case-control study in a Spanish Mediterranean population
Sorli JV, et al.
Appetite 2007 Aug

 

Mental Disorders

The 5HTTLPR polymorphism, prior maltreatment and dramatic-erratic personality manifestations in women with bulimic syndromes
Steiger H, et al.
J Psychiatry Neurosci 2007 Sep;32(5):354-62

Association analysis of exon III and exon I polymorphisms of the dopamine D4 receptor locus in Mexican psychotic patients
Aguirre AJ, et al.
Psychiatry Res 2007 Sep

Lead Burden and Psychiatric Symptoms and the Modifying Influence of the {delta}-Aminolevulinic Acid Dehydratase (ALAD) Polymorphism: The VA Normative Aging Study
Rajan P, et al.
Am J Epidemiol 2007 Sep

Association analysis of HSP90B1 with bipolar disorder
Kakiuchi C, et al.
J Hum Genet 2007 Sep

Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism
Hayden EP, et al.
J Affect Disord 2007 Sep

 

Diseases of the Nervous System and Sense Organs

The p150 subunit of dynactin (DCTN1) gene in multiple sclerosis
Munch C, et al.
Acta Neurol Scand 2007 Oct;116(4):231-4

Cognitive Domain Decline in Healthy Apolipoprotein E {varepsilon}4 Homozygotes Before the Diagnosis of Mild Cognitive Impairment
Caselli RJ, et al.
Arch Neurol 2007 Sep;64(9):1306-11

Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease
Luoma PT, et al.
Neurology 2007 Sep;69(11):1152-9

ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study
van Es MA, et al.
Lancet Neurol 2007 Sep

The Inheritance of Resistance Alleles in Multiple Sclerosis
Ramagopalan SV, et al.
PLoS Genet 2007 Sep;3(9):e150

Increased frequency of positive family history of dementia in sporadic CJD
Krasnianski A, et al.
Neurobiol Aging 2007 Sep

No Association Between the LRRK2 G2019S Mutation and Alzheimer's disease in Italy
Tedde A, et al.
Cell Mol Neurobiol 2007 Sep

 

Diseases of the Circulatory System

Identification of a polymorphism of UCP3 associated with recurrent in-stent restenosis of coronary arteries
Oguri M, et al.
Int J Mol Med 2007 Oct;20(4):533-8

Association of gene polymorphisms with myocardial infarction in individuals with  different lipid profiles
Yoshida T, et al.
Int J Mol Med 2007 Oct;20(4):581-90

Relation between plasma homocysteine, gene polymorphisms of homocysteine metabolism-related enzymes, and angiographically proven coronary artery disease
Laraqui A, et al.
Eur J Intern Med 2007 Oct;18(6):474-83

Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease
Cavallari U, et al.
BMC Med Genet 2007 Sep;8(1):59

Identification of a chromosome 8p locus for early-onset coronary heart disease in a French Canadian population
Engert JC, et al.
Eur J Hum Genet 2007 Sep

The 212A Variant of the APJ Receptor Gene for the Endogenous Inotrope Apelin is Associated With Slower Heart Failure Progression in Idiopathic Dilated Cardiomyopathy
Sarzani R, et al.
J Card Fail 2007 Sep;13(7):521-9

A novel haplotype in ApoAI-CIII-AIV gene region is detrimental to Northwest Indians with coronary heart disease
Singh P, et al.
Int J Cardiol 2007 Sep

Quantitative Assessment of the Effect of Angiotensinogen Gene Polymorphisms on the Risk of Coronary Heart Disease
Xu MQ, et al.
Circulation 2007 Sep

GSTT1 genotype modifies the association between cruciferous vegetable intake and  the risk of myocardial infarction
Cornelis MC, et al.
Am J Clin Nutr 2007 Sep;86(3):752-8

Angiotensinogen M235T polymorphism and left ventricular indices in treated hypertensive patients with normal coronary arteries
Olcay A, et al.
Anadolu Kardiyol Derg 2007 Sep;7(3):257-61

 

Diseases of the Respiratory System

Influence of HLA-DR2 on perforin-positive cells in pulmonary tuberculosis
Rajeswari DN, et al.
Int J Immunogenet 2007 Oct;34(5):379-84

The polymorphisms of Eotaxin 1 and CCR3 genes influence on serum IgE, Eotaxin levels and mild asthmatic children in Taiwan
Wang TN, et al.
Allergy 2007 Oct;62(10):1125-30

Promoter polymorphism of IL-18 gene in pulmonary tuberculosis in South Indian population
Harishankar M, et al.
Int J Immunogenet 2007 Oct;34(5):317-20

Lack of association between three promoter polymorphisms of PTGDR gene and asthma in a Chinese Han population
Li J, et al.
Int J Immunogenet 2007 Oct;34(5):353-7

Mannose binding lectin gene polymorphisms and asthma
Wang X, et al.
Clin Exp Allergy 2007 Sep;37(9):1334-9

Association of IL4R gene polymorphisms with asthma in Chinese populations
Zhang H, et al.
Hum Mutat 2007 Sep;28(10):1046

 

Diseases of the Digestive System

Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and chronic gastritis
Arisawa T, et al.
Int J Mol Med 2007 Oct;20(4):539-44

Role of the PXR gene locus in inflammatory bowel diseases
Martinez A, et al.
Inflamm Bowel Dis 2007 Sep

Analysis of IL-1A (-889) and TNFA (-308) gene polymorphism in Brazilian patients  with generalized aggressive periodontitis
Maria de Freitas N, et al.
Eur Cytokine Netw 2007 Sep;18(3):25-30

The Influence of Polymorphisms of Interleukin-17A and Interleukin-17F Genes on the Susceptibility to Ulcerative Colitis
Arisawa T, et al.
J Clin Immunol 2007 Sep

 

Diseases of the Genitourinary System

Haptoglobin gene polymorphism in type 2 diabetic patients with and without nephropathy: An Egyptian study
Bessa SS, et al.
Eur J Intern Med 2007 Oct;18(6):489-95

Influence of cytokine genes polymorphisms on long-term outcome in renal transplantation
Breulmann B, et al.
Clin Transplant 2007 Sep;21(5):615-21

Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis
Zintzaras E, et al.
J Hum Genet 2007 Sep

NA1/NA2 heterozygote of Fcgr3b is a risk factor for progression of IgA nephropathy in Chinese
Xu G, et al.
J Clin Lab Anal 2007 Sep;21(5):298-302

 

Complications of Pregnancy, Childbirth, and the Puerperium

Vascular endothelial growth factor gene +936 C/T polymorphism is associated with  preeclampsia in Korean women
Shim JY, et al.
Am J Obstet Gynecol 2007 Sep;197(3):271.e1-4

Evaluation of Fetal and Maternal Genetic Variation in the Progesterone Receptor Gene for Contributions to Preterm Birth
Ehn NL, et al.
Pediatr Res 2007 Aug

 

Diseases of the Skin and Subcutaneous Tissue

Vitamin D receptor gene polymorphisms are not associated with alopecia areata
Akar A, et al.
Int J Dermatol 2007 Sep;46(9):927-9

TGF-beta1 Variants in Chronic Beryllium Disease and Sarcoidosis
Jonth AC, et al.
J Immunol 2007 Sep;179(6):4255-62

 

Diseases of the Musculoskeletal System and Connective Tissue

Bone Mass In Prepubertal Boys Is Associated With a Gln223Arg Amino Acid Substitution in the Leptin Receptor
Richert L, et al.
J Clin Endocrinol Metab 2007 Sep

Association of the microsatellite in the 3'UTR of the CD154 gene with rheumatoid  arthritis in females from a Spanish cohort: a case control study
Martin-Donaire T, et al.
Arthritis Res Ther 2007 Sep;9(5):R89

TRAF1-C5 as a Risk Locus for Rheumatoid Arthritis -- A Genomewide Study
Plenge RM, et al.
N Engl J Med 2007 Sep

STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus
Remmers EF, et al.
N Engl J Med 2007 Sep;357(10):977-86

 

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Page last reviewed: September 13, 2007 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics