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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
June 21, 2007
Volume 18, No. 25

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.



Gene Variant Frequency

Frequency of paraoxonase 192/55 polymorphism in an Iranian population
Sepahvand F, et al.
J Toxicol Environ Health A 2007 Jul;70(13):1125-9

Polymorphism C3435T of the MDR1 gene in Central Americans and Spaniards
Vicente J, et al.
Mol Biol Rep 2007 Jun

 

Infectious and Parasitic Diseases

Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population
Gomez LM, et al.
Tissue Antigens 2007 Jul;70(1):28-33

Polymorphism in the manganese superoxide dismutase gene
Elsakka NE, et al.
Free Radic Res 2007 Jul;41(7):770-8

Association of interferon-gamma and interleukin-4 gene polymorphisms with susceptibility to brucellosis in Iranian patients
Rasouli M & Kiany S
Cytokine 2007 Jun

Genetic variants in the NOD2/CARD15 gene are associated with early mortality in sepsis patients
Brenmoehl J, et al.
Intensive Care Med 2007 Jun

Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia
Binder A, et al.
Hum Genet 2007 Jun

Polymorphisms in MICB are associated with human herpes virus seropositivity and schizophrenia risk
Shirts BH, et al.
Schizophr Res 2007 Jun

 

Neoplasms

Food and nutrient intakes and K-ras mutations in exocrine pancreatic cancer
Morales E, et al.
J Epidemiol Community Health 2007 Jul;61(7):641-9

The polymorphisms of interleukin-10 gene influence the prognosis of patients with advanced melanoma
Vuoristo MS
Cancer Genet Cytogenet 2007 Jul;176(1):54-7

MDR1 C3435T Polymorphism in Patients with Breast Cancer
Turgut S, et al.
Arch Med Res 2007 Jul;38(5):539-44

Interleukin-6 Polymorphisms, Helicobacter pylori Infection in Adult Brazilian Patients with Chronic Gastritis and Gastric Adenocarcinoma
Gatti LL, et al.
Arch Med Res 2007 Jul;38(5):551-5

Interleukin-10 gene promoter polymorphisms and the risk of nasopharyngeal carcinoma
Wei YS, et al.
Tissue Antigens 2007 Jul;70(1):12-7

Polymorphism of the DNA repair enzyme XRCC1 is associated with treatment prediction in anthracycline and cyclophosphamide/methotrexate/5-fluorouracil-based chemotherapy of patients with primary invasive breast cancer
Jaremko M, et al.
Pharmacogenet Genomics 2007 Jul;17(7):529-38

Methylenetetrahydrofolate reductase and methionine synthase polymorphisms and risk of bladder cancer in a Tunisian population
Ouerhani S, et al.
Cancer Genet Cytogenet 2007 Jul;176(1):48-53

An association between the MICA-A5.1 allele and an increased susceptibility to oral squamous cell carcinoma in Japanese patients
Tamaki S, et al.
J Oral Pathol Med 2007 Jul;36(6):351-6

Prostate Cancer Progression and Survival in BRCA2 Mutation Carriers
Tryggvadottir L, et al.
J Natl Cancer Inst 2007 Jun

X-ray repair cross-complementing group 1 (XRCC1) single-nucleotide polymorphisms and the risk of salivary gland carcinomas
Ho T, et al.
Cancer 2007 Jun

The low VEGF production allele of the +936C/T polymorphism is strongly associated with increased risk for oral cancer
Yapijakis C, et al.
J Cancer Res Clin Oncol 2007 Jun

IGF-1 CA repeat variant and breast cancer risk in postmenopausal women
Gonzalez-Zuloeta Ladd AM, et al.
Eur J Cancer 2007 Jun

p53 genotypes and haplotypes associated with risk of breast cancer
Buyru N, et al.
Cancer Detect Prev 2007 Jun

Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk
Figueroa JD, et al.
Carcinogenesis 2007 Jun

Regulatory polymorphisms of multidrug resistance 1 (MDR1) gene are associated with the development of childhood acute lymphoblastic leukemia
Hattori H, et al.
Leuk Res 2007 Jun

Frequency and application of the hot spot BRAF gene mutation (p.V600E) in the diagnostic strategy for Hereditary Nonpolyposis Colorectal Cancer
Kadiyska TK, et al.
Cancer Detect Prev 2007 Jun

The Pro variant of the p53 codon 72 polymorphism is associated with hepatocellular carcinoma in Moroccan population
Ezzikouri S, et al.
Hepatol Res 2007 Jun

Lack of an Association between the TGFBR1*6A Variant and Colorectal Cancer Risk
Skoglund J, et al.
Clin Cancer Res 2007 Jun;13(12):3748-52

Epidermal Growth Factor Receptor R497K Polymorphism Is a Favorable Prognostic Factor for Patients with Colorectal Carcinoma
Wang WS, et al.
Clin Cancer Res 2007 Jun;13(12):3597-604

Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: Effect modification by mu class glutathione-S-transferases
Loft S, et al.
Int J Cancer 2007 Jun

Haplotype analysis of CYP11A1 identifies promoter variants associated with breast cancer risk
Yaspan BL, et al.
Cancer Res 2007 Jun;67(12):5673-82

Role of BCL2 (ala43thr), CCND1 (G870A) and FAS (A-670G) polymorphisms in modulating the risk of developing esophageal cancer
Jain M, et al.
Cancer Detect Prev 2007 Jun

Polymorphism in the hMSH2 gene (gISV12-6T > C) is a prognostic factor in non-small cell lung cancer
Hsu HS, et al.
Lung Cancer 2007 Jun

GSTM1 and GSTT1 polymorphisms and the risk of prostate cancer in a Caribbean population of African descent
Mallick S, et al.
Urology 2007 Jun;69(6):1165-9

Correlations of Polymorphisms of TGFB1 and TGFBR2 Genes to Genetic Susceptibility to Gastric Cancer.
Zhou Y, et al.
Ai Zheng 2007 Jun;26(6):581-5


A multigenic study on breast cancer risk associated with genetic polymorphisms of ER Alpha, COMT and CYP19 gene in BRCA1/BRCA2 negative Shanghai women with early onset breast cancer or affected relatives
Hu Z, et al.
J Cancer Res Clin Oncol 2007 Jun

Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosis
Figueiredo JC, et al.
BMC Cancer 2007 Jun;7(1):99

Identification of a protective haplogenotype within CAPN10 gene influencing colorectal cancer susceptibility
Frances CP, et al.
J Gastroenterol Hepatol 2007 Jun

 

Endocrine, Nutritional and Metabolic Diseases

The interaction between the interleukin 6 receptor gene genotype and dietary energy intake on abdominal obesity in Japanese men
Song Y, et al.
Metabolism 2007 Jul;56(7):925-30

Trinucleotide repeats of programmed cell death-1 gene are associated with susceptibility to type 1 diabetes mellitus
Hiromine Y, et al.
Metabolism 2007 Jul;56(7):905-9

ENaCbeta and gamma genes as modifier genes in cystic fibrosis
Viel M, et al.
J Cyst Fibros 2007 Jun

The contribution of genetic variations of aryl hydrocarbon receptor pathway genes to male factor infertility
Merisalu A, et al.
Fertil Steril 2007 Jun

Preliminary analysis of the G178A polymorphism of insulin-like factor 3 in male infertility
Yun YJ, et al.
Fertil Steril 2007 Jun

The IRF5 polymorphism in type 1 diabetes
Qu HQ, et al.
J Med Genet 2007 Jun

Polymorphisms in the B-type natriuretic peptide (BNP) gene are associated with NT-proBNP levels but not with diabetic nephropathy or mortality in type 1 diabetic patients
Lajer M, et al.
Nephrol Dial Transplant 2007 Jun

Association of Prostaglandin E Synthase 2 (PTGES2) Arg298His Polymorphism with Type 2 Diabetes in two German Study Populations
Nitz I, et al.
J Clin Endocrinol Metab 2007 Jun

Alcohol consumption and type 2 diabetes: influence of genetic variation in alcohol dehydrogenase
Beulens JW, et al.
Diabetes 2007 Jun

 

Mental Disorders

Effect of ADH1B Genotype on Alcohol Consumption in Young Israeli Jews
Spivak B, et al.
Alcohol Clin Exp Res 2007 Jun

Partial Replication of a DRD4 Association in ADHD Individuals Using a Statistically Derived Quantitative Trait for ADHD in a Family-Based Association Test
Lasky-Su J, et al.
Biol Psychiatry 2007 Jun

Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence
Williams TJ, et al.
Addict Biol 2007 Jun

TGFBR2 gene expression and genetic association with schizophrenia
Numata S, et al.
J Psychiatr Res 2007 Jun

Association of the Dopamine D4 Receptor (DRD4) Gene and Approach-Related Personality Traits: Meta-Analysis and New Data
Munafo MR, et al.
Biol Psychiatry 2007 Jun

No association between the tumor necrosis factor-alpha gene promoter polymorphisms and schizophrenia in a Japanese population
Watanabe Y, et al.
Psychiatry Res 2007 Jun

 

Diseases of the Nervous System and Sense Organs

Inflammatory cytokine gene polymorphisms and increased risk of Parkinson disease
Wahner AD, et al.
Arch Neurol 2007 Jun;64(6):836-40

NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner
Arning L, et al.
Hum Genet 2007 Jun

Association between the G1246A polymorphism of the hypocretin receptor 2 gene and cluster headache: a meta-analysis
Rainero I, et al.
J Headache Pain 2007 Jun

Combined Effect of Apolipoprotein E Genotype and Past Fertility on Age at Onset of Alzheimer's Disease in Women
Corbo RM, et al.
Dement Geriatr Cogn Disord 2007 Jun;24(2):82-5

Are interrupted SCA2 CAG repeat expansions responsible for parkinsonism?
Charles P, et al.
Neurology 2007 Jun

Association of the HTRA1 gene variant with age-related macular degeneration in the Japanese population
Mori K, et al.
J Hum Genet 2007 Jun

 

Diseases of the Circulatory System

CYBA C242T gene polymorphism and flow-mediated vasodilation in a population of young adults: the Cardiovascular Risk in Young Finns Study
Fan M, et al.
J Hypertens 2007 Jul;25(7):1381-7

Synergistic Effects between Q192R Polymorphism of Paraoxonase 1 Gene and Some Conventional Risk Factors in Premature Coronary Artery Disease
Balcerzyk A, et al.
Arch Med Res 2007 Jul;38(5):545-50

The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9
Visser LE, et al.
Pharmacogenet Genomics 2007 Jul;17(7):473-9

Thr164Ile polymorphism of beta2-adrenergic receptor negatively modulates cardiac contractility: implications for prognosis in patients with idiopathic dilated cardiomyopathy
Barbato E, et al.
Heart 2007 Jul;93(7):856-61

Interaction effects of high-density lipoprotein metabolism gene variation and alcohol consumption on coronary heart disease risk: the atherosclerosis risk in communities study
Volcik K, et al.
J Stud Alcohol Drugs 2007 Jul;68(4):485-92

The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study
Isaacs A, et al.
Eur J Cardiovasc Prev Rehabil 2007 Jun;14(3):419-21

Apolipoprotein E polymorphisms influence effect of pravastatin on survival after myocardial infarction in a Mediterranean population: the GISSI-Prevenzione study
Chiodini BD, et al.
Eur Heart J 2007 Jun

A Polymorphism in the Protease-Like Domain of Apolipoprotein(a) Is Associated With Severe Coronary Artery Disease
Luke MM, et al.
Arterioscler Thromb Vasc Biol 2007 Jun

Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension
Braga Marcano AC, et al.
J Med Genet 2007 Jun

Relationship between angiotensin converting enzyme gene and ischemic stroke.
Li CM, et al.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2007 Jun;19(6):321-4

Platelet glycoprotein IIb HPA-3 polymorphism and acute coronary syndromes
Lekakis J, et al.
Int J Cardiol 2007 Jun

 

Diseases of the Respiratory System

Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children
Chan IH, et al.
Allergy 2007 Jul;62(7):802-9

Association of ICAM3 Genetic Variant with Severe Acute Respiratory Syndrome
Chan KY, et al.
J Infect Dis 2007 Jul;196(2):271-80

Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood
Hunninghake GM, et al.
J Allergy Clin Immunol 2007 Jun

Polymorphisms and functional activity in SOD and catalase genes in smokers with COPD
Mak JC, et al.
Eur Respir J 2007 Jun

E-Selectin S128R Polymorphism Leads to Severe Asthma
Nadi E, et al.
Iran J Allergy Asthma Immunol 2007 Jun;6(2):49-57

A Functional Polymorphism in the TIM-1 Gene Is Associated with Asthma in a Chinese Han Population
Liu Q, et al.
Int Arch Allergy Immunol 2007 Jun;144(3):197-202

 

Diseases of the Digestive System

Lack of association between chronic periodontitis and the Toll-like receptor 4 gene polymorphisms in a Czech population
Izakovicova Holla L, et al.
J Periodontal Res 2007 Aug;42(4):340-4

Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases
Weersma RK, et al.
Scand J Gastroenterol 2007 Jul;42(7):827-33

A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
van Heel DA, et al.
Nat Genet 2007 Jun

Analysis of the NOD2/CARD15 Gene in Patients Affected with the Aseptic Abscesses Syndrome with or without Inflammatory Bowel Disease
Andre MF, et al.
Dig Dis Sci 2007 Jun

Analysis of polymorphisms of tumor necrosis factor-alpha and polymorphic xenobiotic metabolizing enzymes in inflammatory bowel disease: Study from northern India
Mittal RD, et al.
J Gastroenterol Hepatol 2007 Jun;22(6):920-4

A genetic association study of 5-HTT LPR and GNbeta3 C825T polymorphisms with irritable bowel syndrome
Saito YA, et al.
Neurogastroenterol Motil 2007 Jun;19(6):465-70

Genetic polymorphisms of CD14 and Toll-like receptor-2 (TLR2) in patients with ulcerative colitis
Wang F, et al.
J Gastroenterol Hepatol 2007 Jun;22(6):925-9

 

Diseases of the Genitourinary System

Single nucleotide polymorphisms and haplotypes of the genes encoding the CYP1B1 in Korean women: No association with advanced endometriosis
Cho YJ, et al.
J Assist Reprod Genet 2007 Jun

Variants in EMX2 and PTEN do not contribute to risk of endometriosis
Treloar SA, et al.
Mol Hum Reprod 2007 Jun

 

Complications of Pregnancy, Childbirth, and the Puerperium

Factor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkey
Altintas A, et al.
Ann Hematol 2007 Jun

 

Diseases of the Skin and Subcutaneous Tissue

Putative association of a TLR9 promoter polymorphism with atopic eczema
Novak N, et al.
Allergy 2007 Jul;62(7):766-72

The association between endothelin-1 gene polymorphisms and susceptibility to vitiligo in a Korean population
Kim HJ, et al.
Exp Dermatol 2007 Jul;16(7):561-6

HLA class II amino acid epitopes as susceptibility markers of sarcoidosis
Voorter CE, et al.
Tissue Antigens 2007 Jul;70(1):18-27

Linkage between Toll-like receptor (TLR) 2 promotor and intron polymorphisms: functional effects and relevance to sarcoidosis
Veltkamp M, et al.
Clin Exp Immunol 2007 Jun

TGF-beta(1) gene polymorphism in psoriasis vulgaris
Baran W, et al.
Cytokine 2007 Jun

 

Diseases of the Musculoskeletal System and Connective Tissue

Single nucleotide polymorphisms in the P2X7 gene are associated to fracture risk and to effect of estrogen treatment
Ohlendorff SD, et al.
Pharmacogenet Genomics 2007 Jul;17(7):555-67

Lack of association between the chemokine receptor 5 polymorphism CCR5delta32 in rheumatoid arthritis and juvenile idiopathic arthritis
Lindner E, et al.
BMC Med Genet 2007 Jun;8(1):33

Polymorphism in the tumor necrosis factor-alpha gene promoter is associated with severity of rheumatoid arthritis in the Czech population
Nemec P, et al.
Clin Rheumatol 2007 Jun

Opposed independent effects and epistasis in the complex association of IRF5 to SLE
Ferreiro-Neira I, et al.
Genes Immun 2007 Jun

APRIL polymorphism and systemic lupus erythematosus (SLE) susceptibility
Lee YH, et al.
Rheumatology (Oxford) 2007 Jun

Tumor necrosis factor-alpha haplotype is strongly associated with bone mineral density in patients with Crohn's disease
Lee N, et al.
J Gastroenterol Hepatol 2007 Jun;22(6):913-9

 

Injury and Poisoning

Glutathione S-Transferases GSTM1 and GSTT1 Polymorphisms and Asbestosis
Franko A, et al.
J Occup Environ Med 2007 Jun;49(6):667-71

 

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Page last reviewed: June 21, 2007 (archived document)
Page last updated: November 2, 2007
Content Source: National Office of Public Health Genomics