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Genomics and Health Weekly Update

Human Genome Epidemiology (HuGE) Articles
August 17, 2006
Volume 17, No. 7

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Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.


Infectious and Parasitic Diseases

A Polymorphism That Reduces RANTES Expression Is Associated with Protection from Death in HIV-Seropositive Ugandans with Advanced Disease
Cooke GS, et al.
J Infect Dis 2006 Sep;194(5):666-9

The IL-10 -1082G polymorphism is associated with clearance of HPV infection
Farzaneh F, et al.
BJOG 2006 Aug;113(8):961-4

Association of TNF-alpha promoter polymorphisms with the outcomes of hepatitis B virus infection in Chinese Han population
Du T, et al.
J Viral Hepat 2006 Sep;13(9):618-24

Toll-like receptor 2 Arg753Gln gene polymorphism in Turkish patients with Behcet's disease
Bacanli A, et al.
Clin Exp Dermatol 2006 Sep;31(5):699-701

           

 

Neoplasms

The Prevalence of CDKN2A Germ-Line Mutations and Relative Risk for Cutaneous Malignant Melanoma: An International Population-Based Study
Berwick M, et al.
Cancer Epidemiol Biomarkers Prev 2006 Aug;15(8):1520-5

A meta-analysis of genotypes and haplotypes of methylenetetrahydrofolate reductase gene polymorphisms in acute lymphoblastic leukemia
Zintzaras E, et al.
Eur J Epidemiol 2006 Aug

MDM2 SNP309 and SNP354 Are Not Associated with Lung Cancer Risk
Pine SR, et al.
Cancer Epidemiol Biomarkers Prev 2006 Aug;15(8):1559-61

DNA-Repair Gene Polymorphisms Predict Favorable Clinical Outcome Among Patients With Advanced Squamous Cell Carcinoma of the Head and Neck Treated With Cisplatin-Based Induction Chemotherapy
Quintela-Fandino M, et al.
J Clin Oncol 2006 Aug

N-Acetyltransferase (NAT) 2 acetylator status and age of tumour onset in patients with sporadic and familial, microsatellite stable (MSS) colorectal cancer
Pistorius S, et al.
Int J Colorectal Dis 2006 Aug

Deletion Polymorphism of UDP-Glucuronosyltransferase 2B17 and Risk of Prostate Cancer in African American and Caucasian Men
Park J, et al.
Cancer Epidemiol Biomarkers Prev 2006 Aug;15(8):1473-8

Pharmacogenetics of SLCO1B1 gene and the impact of *1b and *15 haplotypes on irinotecan disposition in Asian cancer patients
Xiang X, et al.
Pharmacogenet Genomics 2006 Sep;16(9):683-91

Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia
Jawad M, et al.
Blood 2006 Aug

No Association of DNA Ligase-I Polymorphism with the Risk of Lung Cancer in North-Indian Population
Sobti RC, et al.
DNA Cell Biol 2006 Aug;25(8):484-9

Association of VEGF genetic polymorphisms with prostate carcinoma risk and clinical outcome
Sfar S, et al.
Cytokine 2006 Aug

Genotype-Phenotype Comparison of German MLH1 and MSH2 Mutation Carriers Clinically Affected With Lynch Syndrome: A Report by the German HNPCC Consortium
Goecke T, et al.
J Clin Oncol 2006 Aug

 

Endocrine, Nutritional and Metabolic Diseases

Candidate genes and polymorphism analysis in type 2 diabetes mellitus
Zietz B, et al.
Med Klin (Munich) 2006 Aug;101(8):605-16

NeuroD1 Gene and Interleukin-18 Gene Polymorphisms in Type 1 Diabetes in Dalmatian Population of Southern Croatia
Boraska V, et al.
Croat Med J 2006 Aug;47(4):571-8

Meta-Analysis of Vitamin D Receptor Polymorphisms and Type 1 Diabetes: A HuGE Review of Genetic Association Studies
Guo SW, et al.
Am J Epidemiol 2006 Aug

Genetic association studies of the FOXP3 gene in Graves' disease and autoimmune Addison's disease in the United Kingdom population
Owen CJ, et al.
J Mol Endocrinol 2006 Aug;37(1):97-104

UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females
Mercke Odeberg J, et al.
Eur J Clin Pharmacol 2006 Aug

Thr-encoding Allele Homozygosity at Codon 54 of FABP 2 Gene May be Associated with Impaired Delta 6 Desatruase Activity and Reduced Plasma Arachidonic Acid in Obese Children
Okada T, et al.
J Atheroscler Thromb 2006;13(4):192-6

[Polymorphism I/D of the angiotensin-converting enzyme gene and disturbance of blood prssure in type 1 diabetic children and adolescents]
Szadkowska A, et al.
Przegl Lek 2006;63 Suppl 3:32-6

Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men
Kokaze A, et al.
J Hum Genet 2006 Aug

 

Diseases of the Blood & Blood-Forming Organ Disorders

The clinical impact of MTHFR polymorphism on the vascular complications of sickle cell disease
Moreira Neto F, et al.
Braz J Med Biol Res 2006 Aug

Polymorphisms in interleukin 8 and its receptors (IL8, IL8RA and IL8RB) and association of common IL8 receptor variants with peripheral blood eosinophil counts
Cheong HS, et al.
J Hum Genet 2006 Aug

 

Mental Disorders

The association of DNA sequence variation at the MAOA genetic locus with quantitative behavioural traits in normal males
Rosenberg S, et al.
Hum Genet 2006 Aug

           

The GNB3 C825T polymorphism and depression among subjects with alcohol dependence
Prestes AP, et al.
J Neural Transm 2006 Aug

No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population
Meng J, et al.
J Neural Transm 2006 Aug

Association study of IL10, IL1beta, and IL1RN and schizophrenia using tag SNPs from a comprehensive database: Suggestive association with rs16944 at IL1beta
Shirts BH, et al.
Schizophr Res 2006 Aug

RGS4 mRNA Expression in Postmortem Human Cortex Is Associated with COMT Val158Met Genotype and COMT Enzyme Activity
Lipska BK, et al.
Hum Mol Genet 2006 Aug

Interaction between catechol-O-methyltransferase (COMT) Val108/158Met and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in age at onset and clinical symptoms in schizophrenia
Numata S, et al.
J Neural Transm 2006 Aug

Imaging gene-substance interactions: The effect of the DRD2 TaqIA polymorphism and the dopamine agonist bromocriptine on the brain activation during the anticipation of reward
Kirsch P, et al.
Neurosci Lett 2006 Sep;405(3):196-201

The 196G/A (val66met) polymorphism of the BDNF gene is significantly associated with binge eating behavior in women with bulimia nervosa or binge eating disorder
Monteleone P, et al.
Neurosci Lett 2006 Aug

Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks
Thoeringer CK, et al.
J Psychiatr Res 2006 Aug

RGS4 polymorphisms and risk of schizophrenia: An association study in Han Chinese plus meta-analysis
Guo S, et al.
Neurosci Lett 2006 Aug

No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population
Tochigi M, et al.
Schizophr Res 2006 Aug

Schizophrenia and Oxidative Stress: Glutamate Cysteine Ligase Modifier as a Susceptibility Gene
Tosic M, et al.
Am J Hum Genet 2006 Sep;79(3):586-92

The Impact of Tryptophan Depletion and 5-HTTLPR Genotype on Passive Avoidance and Response Reversal Instrumental Learning Tasks
Finger EC, et al.
Neuropsychopharmacology 2006 Aug

Genetics and personality traits in patients with social anxiety disorder: A case-control study in South Africa
Lochner C, et al.
Eur Neuropsychopharmacol 2006 Aug

Association study of the dystrobrevin-binding gene with schizophrenia in Australian and Indian samples
Holliday EG, et al.
Twin Res Hum Genet 2006 Aug;9(4):531-9

 

Diseases of the Nervous System and Sense Organs

C677T Methylentetrahydrofulate Reductase and Angiotensin Converting Enzyme Gene Polymorphisms in Patients with Alzheimer's Disease in Iranian Population
Keikhaee MR, et al.
Neurochem Res 2006 Aug

Systematic review and meta-analysis of the association between complementary factor H Y402H polymorphisms and age-related macular degeneration
Thakkinstian A, et al.
Hum Mol Genet 2006 Aug

Variations in the BDNF Gene in Autopsy-Confirmed Alzheimer's Disease and Dementia with Lewy Bodies in Japan
Akatsu H, et al.
Dement Geriatr Cogn Disord 2006 Aug;22(3):216-22

Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis
Barcellos LF, et al.
Hum Mol Genet 2006 Aug

CD24 V/V is an allele associated with the risk of developing multiple sclerosis in the Spanish population
Otaegui D, et al.
Mult Scler 2006 Aug;12(4):511-4

Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease
Maraganore DM, et al.
JAMA 2006 Aug;296(6):661-70

Investigating the Relationship Between FMR1 Allele Length and Cognitive Ability in Children: A Subtle Effect of the Normal Allele Range on the Normal Ability Range?
Loat CS, et al.
Ann Hum Genet 2006 Sep;70(5):555-65

Prion protein gene M129 allele is a risk factor for Alzheimer's disease
Gacia M, et al.
J Neural Transm 2006 Aug

A TGF-beta1 polymorphism association with dementia and neuropathologies: The HAAS
Peila R, et al.
Neurobiol Aging 2006 Aug

The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan
Wang IJ, et al.
Mol Vis 2006;12:852-7

Apolipoprotein E varepsilon4 allele in familial and sporadic Parkinson's disease
Blazquez L, et al.
Neurosci Lett 2006 Aug

Tumor Necrosis Factor {alpha} and Interleukin 10 Promoter Region Polymorphisms and Risk of Late-Onset Alzheimer Disease
Ramos EM, et al.
Arch Neurol 2006 Aug;63(8):1165-9

C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency
Jacobsen LK, et al.
Psychopharmacology (Berl) 2006 Aug

No evidence of association between BDNF gene variants and age-at-onset of Huntington's disease
Di Maria E, et al.
Neurobiol Dis 2006 Aug

Diseases of the Circulatory System

Contribution of the -455G/A polymorphism at beta-fibrinogen gene and of the Leiden mutation to hemorheological parameters in ischemic stroke patients
Pongracz E, et al.
Clin Hemorheol Microcirc 2006;35(1-2):75-82

G-protein beta3 subunit (GNB3) gene polymorphisms and cardiovascular disease: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study
Renner W, et al.
Atherosclerosis 2006 Aug

Lack of Association Between Genetic Variation in 9 Innate Immunity Genes and Baseline CRP Levels
Kozlowski P, et al.
Ann Hum Genet 2006 Sep;70(5):574-86

Adrenergic Receptor Polymorphisms Associated with Resting Heart Rate: The HyperGEN Study
Wilk JB, et al.
Ann Hum Genet 2006 Sep;70(5):566-73

Homozygosity in the Single Nucleotide Polymorphism Ser128Arg in the E-Selectin Gene Associated With Recurrent Venous Thromboembolism
Jilma B, et al.
Arch Intern Med 2006 Aug;166(15):1655-9

Associations of PPARGC1A Haplotypes With Plaque Score But Not With Intima-Media Thickness of Carotid Arteries in Middle-Aged Subjects
Iglseder B, et al.
Stroke 2006 Aug

Role of five platelet membrane glycoprotein polymorphisms in branch retinal vein occlusion
Salomon O, et al.
Blood Coagul Fibrinolysis 2006 Sep;17(6):485-8

The role of genetic variants of matrix metalloproteinases in coronary and carotid atherosclerosis
Abilleira S, et al.
J Med Genet 2006 Aug

Association of the T+294C polymorphism in PPAR delta with low HDL cholesterol and coronary heart disease risk in women
Aberle J, et al.
Int J Med Sci 2006;3(3):108-11

[Mutation in factor II and factor V gene in patients with peripheral arterial occlusive disease.]
Abukishe A, et al.
Hamostaseologie 2006 Aug;26(3):197-200

 

Diseases of the Respiratory System

No associations of human pulmonary tuberculosis with Sp110 variants
Thye T, et al.
J Med Genet 2006 Jul;43(7):e32

Association Between Nonspecific Airway Hyperresponsiveness and Arg16Gly {beta}2-Adrenergic Receptor Gene Polymorphism in Asymptomatic Healthy Japanese Subjects
Fukui Y, et al.
Chest 2006 Aug;130(2):449-54

 

Diseases of the Digestive System

The short vitamin D receptor is associated with increased risk for generalized aggressive periodontitis
Park KS, et al.
J Clin Periodontol 2006 Aug;33(8):524-8

Interleukin-6 receptor gene polymorphisms and periodontitis in a non-smoking Japanese population
Galicia JC, et al.
J Clin Periodontol 2006 Aug

Genetic polymorphisms in the MMP-1 and MMP-3 gene may contribute to chronic periodontitis in a Brazilian population
Astolfi CM, et al.
J Clin Periodontol 2006 Aug

NADPH oxidase (CYBA) and FcgammaR polymorphisms as risk factors for aggressive periodontitis: A case-control association study
Nibali L, et al.
J Clin Periodontol 2006 Aug;33(8):529-39

 

Diseases of the Genitourinary System

P53 codon 11, 72, and 248 gene polymorphisms in endometriosis
Hsieh YY & Lin CS
Int J Biol Sci 2006;2(4):188-93

Cyp3A4, Cyp3A5, and MDR-1 genetic influences on tacrolimus pharmacokinetics in renal transplant recipients
Roy JN, et al.
Pharmacogenet Genomics 2006 Sep;16(9):659-65

Association of genetic markers within the KIT and KITLG genes with human male infertility
Galan JJ, et al.
Hum Reprod 2006 Aug

WT1 mutations in nephrotic syndrome revisited. High prevalence in young girls, associations and renal phenotypes
Aucella F, et al.
Pediatr Nephrol 2006 Aug

 

Complications of Pregnancy, Childbirth, and the Puerperium

Cognitive outcome and cyclooxygenase-2 Gene (-765 G/C) variation in the preterm
Harding D, et al.
Arch Dis Child Fetal Neonatal Ed 2006 Aug

 

Diseases of the Skin and Subcutaneous Tissue

Genetically determined imbalance between serum levels of tumour necrosis factor (TNF) and interleukin (IL)-10 is associated with anti-Jo-1 and anti-Ro52 autoantibodies in patients with poly- and dermatomyositis
Hassan AB, et al.
J Autoimmun 2006 Aug

ACE I/D-corrected Z-scores to identify normal and elevated ACE activity in sarcoidosis
Kruit A, et al.
Respir Med 2006 Aug

 

Diseases of the Musculoskeletal System and Connective Tissue

The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis
Uitterlinden AG, et al.
Ann Intern Med 2006 Aug;145(4):255-64

Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis
Lee YH, et al.
Rheumatol Int 2006 Aug

Evidence for involvement of the vitamin D receptor gene in idiopathic short stature via a genome wide linkage study and subsequent association studies
Dempfle A, et al.
Hum Mol Genet 2006 Aug

IL-1RN gene polymorphism is associated with peri-implantitis
Laine ML, et al.
Clin Oral Implants Res 2006 Aug;17(4):380-5

HLA-G 14-bp polymorphism regulates the methotrexate response in rheumatoid arthritis
Rizzo R, et al.
Pharmacogenet Genomics 2006 Sep;16(9):615-23

Risk of limb deficiency defects associated with NAT1, NAT2, GSTT1, GSTM1, and NOS3 genetic variants, maternal smoking, and vitamin supplement intake
Carmichael SL, et al.
Am J Med Genet A 2006 Aug

 

Congenital Anomalies

High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts
Park JW, et al.
J Med Genet 2006 Jul;43(7):598-608

 

 

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