Genomics|Family History|Tables|Ovarian Cancer Among Jewish Women

Increased Risk for Familial Ovarian Cancer Among Jewish Women: A Population-Based Case-Control Study
Karen K. Steinberg, Janet M. Pernarelli, Michele Marcus, Muin J. Khoury, Joellen M. Schildkraut, Polly A. Marchbank

Tables

TABLE 1: Demographic and risk factor characteristics of women with familial epithelial ovarian cancer, nonfamilial epithileal ovarian cancer, and control women from the cancer and steroid hormone study.

Epithelial ovarian cancer cases

Controls

Variables

Familial^a (total = 16)
N (%)

Nonfamilial (total = 455)
N (%)

(total = 4,025)

Birth year

< 1930

1930-1939

1940+

Unknown

4 (25.0)

9 (56.3)

3 (18.8)

0 ( 0.0)

85 (18.7)

204 (44.8)

166 (36.5)

0 ( 0.0)

653 (16.2)

1,846 (45.9)

1,526 (37.9)

0 ( 0.0)

Menopause status

Premenopausal

Perimenopausal

Natural menopause

Surgical menopause

Unknown

4 (25.0)

2 (12.5)

7 (43.8)

2 (12.5)

1 ( 6.3)

197 (43.3)

96 (21.1)

91 (20.0)

46 (10.1)

25 ( 5.5)

1,758 (43.7)

813 (20.2)

628 (15.6)

680 (16.9)

144 ( 3.6)

Age at menopause

< 40 years

40 - 49.9

50+

Unknown

3 (25.0)

8 (66.7)

1 ( 8.3)

0 ( 0.0)

46 (17.8)

145 (56.2)

66 (25.6)

1 (0.4)

539 (23.8)

1,259 (55.5)

455 (20.1)

14 ( 0.6)

Total pregnancies

none

2-3

Unknown

0 (0)

2 (12.5)

7 (43.7)

0 ( 0.0)

92 (20.2)

65 (14.3)

190 (41.8)

107 (23.5)

1 ( 0.2)

397 (9.9)

350 (8.7)

1,623 (40.3)

1,651 (41.0)

4 ( 0.1)

Anovulatory cycles

none

1 - 24

25 - 49

50+

Unknown

0 (0)

6 (37.5)

8 (50.0)

2 (12.5)

0 ( 0.0)

92 (20.2)

177 (38.9)

141 (31.0)

39 ( 8.6)

6 ( 1.3)

397 ( 9.9)

1,215 (30.2)

1,605 (39.9)

748 (18.6)

60 ( 1.5)

Education

<=12th grade

13 - 16

>16

Unknown

8 (50.0)

5 (31.3)

3 (18.8)

0 ( 0.0)

241 (53.0)

159 (34.9)

55 (12.1)

0 ( 0.0)

1,900 (47.2)

1,571 (39.0)

550 (13.7)

4 ( 0.1)

Oral contraceptive use

none

<= 3 mos

> 3 mos

Unknown

6 (37.5)

2 (12.5)

8 (50.0)

0 ( 0.0)

221 (48.6)

41 (9.0)

191 (42.0)

2 ( 0.4)

1,439 (35.8)

240 (6.0)

2,337 (58.1)

9 ( 0.2)

^aFamilial ovarian cancer was defined as cases of ovarian cancer among women with first degree relatives (sisters, mothers, daughters- although there were no affected daughters) reported as having ovarian cancer. Twenty three women with ovarian cancer and 128 without were excluded from this analysis because their family history was unknown.

TABLE 2: Unadjusted odds ratios for ovarian cancer among Jewish women.

	Familial ovarian cancer^a	Non-familial ovarian cancer	Controls
Religion
Jewish	3	15	107
Non-Jewish	13	440	3,913
Odds ratio	8.4 (2.6 - 28.1)	1.25 (0.72 - 2.1)	1.0

^aFamilial ovarian cancer was defined as cases of ovarian cancer among women having a mother, sister, or daughter with ovarian cancer. Five women without ovarian cancer were excluded from this analysis because their religion was unknown, and 23 women with ovarian cancer and 128 without were excluded because their family history was unknown.

TABLE 3: Crude odds ratios for ovarian cancer among Jewish and non-Jewish women with and without a family history of ovarian cancer and the interaction between family history and religion in Jewish women.^a

	Cases	Controls	Crude OR	95% CI
Not Jewish/No family history	440	3,875	1.00	_
Jewish/No family history	15	104	1.27	0.74 - 2.19
Not Jewish/Family history	13	38	3.01	1.61 - 5.64
Jewish/Family history	3	3	8.81	2.02 - 38.23

^aFive women without ovarian cancer were excluded from this analysis because their religion was unknown, and 23 women with ovarian cancer and 128 without were excluded because their family history was unknown.