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| Shawn Burgess, Ph.D., Investigator |
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Dr. Burgess received his B.A. from Wesleyan University in 1988 and his Ph.D. from Johns Hopkins School of Medicine, Maryland in 1995 where he studied genetics. He received his postdoctoral training from Dr. Nancy Hopkins at Massachusetts Institute of Technology, where he developed pseudotyped retroviruses as an insertional mutatgen in zebrafish. He was awarded the Paul Earlich Award for excellence in clinical research in 1995 and the Amgen Postdoctoral fellow at MIT in 1997. Dr. Burgess joined NHGRI as Head, Developmental Genomics Section in 2000. His laboratory uses zebrafish as a model organism to identify and functionally characterize novel developmental genes in order to establish the genomics of human ear development.
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Selected Recent Publications:
Kurita K, Burgess S, Sakai N. (2004) Transgenic zebrafish produced by retroviral infection of in vitro cultured sperm, PNAS In Press.
Nissen R, Yan J, Amsterdam A, Hopkins N, and Burgess S. (2003) Zebrafish foxi one modulates cellular responses to fgf signaling required for the integrity of ear and jaw patterning, Dev. 130, 2543-2554.
Wu X, Li Y, Crise B, Burgess S. (2003) Transcription start regions in the human genome are favored targets for MLV integration, Science 300, 1749-1751.
Burgess, S, Reim, G, Hopkins, N, and Brand, M, (2002) The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 and is essential for formation of the midbrain, hindbrain and for pre-gastrula morphogenesis, Dev. 129, 905-916.
Chen, W, Burgess, S, Golling, G, Amsterdam, A, and Hopkins, N. (2002) High-Throughput Selection of Retrovirus Producer Cell Lines Leads to Markedly Improved Efficiency of Germ Line-Transmissible Insertions in Zebrafish, J. Vir. 76, 2192-2198.
Golling G, Amsterdam A, Sun Z, Antonelli M, Maldonado E, Chen W, Burgess S, Haldi M, Artzt K, Farrington S, Lin SY, Nissen RM, and Hopkins N (2002) Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development, Nat. Genet. 31, 135-140.
Chen, W, Burgess, S, and Hopkins, N. (2001) Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity, Dev. 128, 2385-2396.
All Selected Publications
Contact Information:
Dr. Shawn Burgess
Developmental Genomics Section
Genome Technology Branch, NHGRI
Building 50, Room 5537
50 South Drive, MSC 8004
Bethesda, MD 20892-8004
Telephone: (301) 594-8224 (office),
(301) 594-8224 (laboratory),
(301) 496-0474 (fax)
Email: burgess@nhgri.nih.gov
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