Study	Comments	Drug(s)	Outcome
Meyers et al. 1998 [37]	Brain tumor; N = 30	methylphenidate (Ritalin)	↑ mood, ↑ cognition, ↑ function
Olin and Masand 1996 [38]	Mixed cancer; N = 59; chart review	dextroamphetamine (Dexedrine); methylphenidate (Ritalin)	↓ depression, ↑ appetite
Bruera et al. 1992 [39]	Cancer pain vs. opioid infusion; N = 20	methylphenidate (Ritalin); placebo	↑ cognition, ↓ sedation
Fernandez et al. 1987 [36]	Mixed cancer; rapid onset; N = 30	methylphenidate (Ritalin;up to 80 mg)	↓ depression
Bruera et al. 1986 [40]	Pain; double-blind cross-over study; N = 24	mazindol (Mazanor)	↓ pain, ↓ appetite, no effect on mood
Joshi et al. 1982 [41]	Terminally ill	amphetamine	↑ comfort

References

36. Fernandez F, Adams F, Holmes VF, et al.: Methylphenidate for depressive disorders in cancer patients. An alternative to standard antidepressants. Psychosomatics 28 (9): 455-61, 1987.  [PUBMED Abstract]
    
    
37. Meyers CA, Weitzner MA, Valentine AD, et al.: Methylphenidate therapy improves cognition, mood, and function of brain tumor patients. J Clin Oncol 16 (7): 2522-7, 1998.  [PUBMED Abstract]
    
    
38. Olin J, Masand P: Psychostimulants for depression in hospitalized cancer patients. Psychosomatics 37 (1): 57-62, 1996 Jan-Feb.  [PUBMED Abstract]
    
    
39. Bruera E, Miller MJ, Macmillan K, et al.: Neuropsychological effects of methylphenidate in patients receiving a continuous infusion of narcotics for cancer pain. Pain 48 (2): 163-6, 1992.  [PUBMED Abstract]
    
    
40. Bruera E, Carraro S, Roca E, et al.: Double-blind evaluation of the effects of mazindol on pain, depression, anxiety, appetite, and activity in terminal cancer patients. Cancer Treat Rep 70 (2): 295-8, 1986.  [PUBMED Abstract]
    
    
41. Joshi JH, de Jongh CA, Schnaper N, et al.: Amphetamine therapy for enhancing the comfort of terminally ill patients with cancer. Proceedings of the American Society of Clinical Oncology 1: 55, 1982.