A Selected List of
Company and Institute Resources
Providing New Technologies
Revised June 1998

Antibodies Inc.
P.O. Box 1560, Davis, CA 95617, USA
Telephone: (916) 758-4400, Fax: (916) 758-6307
E-mail: antiinc@aol.com

Manufacture monoclonal and polyclonal antibodies, custom antiserums, and diagnostic kits. Production via cell culture, fermentors, hybridomas, and small reactors.

BIOCULT
Antibody Production Centre
Aacademic Business Centre of Leiden University
Niels Bohrweg 11-13 K2, 2333 CA, Leiden, The Netherlands
Telephone: (31)-71-21 54 43 or (31)-71-27 68 62, Fax: (31)-71-21 72 72 (from U.S. 31-715217272)
E-mail: appeldoo@chem.leidenuniv.nl

Independent contract house for cell derived monoclonal antibodies. Activities focus on in vitro cultures. Use hollow fiber bioreactor perfusion systems and have processed over 25 different cell lines.

Biodesign International
60 Industrial Park Road
Saco, ME 04072, USA
Telephone: (888) 530-0140 (toll free US only) (207) 283-6500, Fax: (207) 283-4800
E-mail: info@biodesign.com
URL: http://meridianlifescience.com/about_us/about_biodesign.asp

Offers custom monoclonal antibody development for research and manufacturing. In vitro monoclonal antibody production services utilizing bioreactors and serum-free medium. Ascites production in mice.

BioInvent Production AB
S-223 70 Lund, Sweden
Telephone: +46-46-168550, Fax: +46-46-2110806
E-mail: info@bioinvent.se
URL: http://www.bioinvent.se

Swedish company specializing in the development and production of monoclonal antibodies, including antibody engineering, cellular technology, cell culture and purification. Offering a choice of technologies available for continuous perfusion culture (Cellex, Acusyst, Xcell, and Opticell systems).

BIOMEDA
P.O. Box 8045, Foster City, CA 94404, USA
Telephone: (415) 341-8787, Toll free: 1- (800) 341-8787 or , Fax: (415) 341-2299
E-mail: support@biomeda.com
URL: http://www.biomeda.com

Offer a wide variety of monoclonal and polyclonal antibodies for research purposes produced in mice, rabbits, and goats. In vitro and cell culture technologies used in production when possible.

Biosynthesis Incorporated
Post Office Box 28
Lewisville, TX 75067-0028, USA
Telephone: (972) 420-8505, Toll free: (800) 227-0627, Fax: (972) 420-0442
E-mail: biosyn@onramp.net
URL: http://www.biosyn.com

Offer chicken polyclonal antibody services. Option to store eggs for an extra charge. IgY extraction from one dozen eggs. Polyclonals also available from rabbits, sheep and goats. Monoclonals produced by ascites in mice.

Cellco, Inc. (see Spectrum)
12321 Middlebrook Road, Suite 210, Germantown, MD 20874, USA
Telephone: (301) 916-1000, Toll free: (800) 253-1803, Fax: (301) 916-1010
E-mail: cellco@cellco.com
URL: http://www.spectrumlabs.com

Producers of CELLMAX®, artificial capillary cell culture systems designed to culture hybridoma, lymphocytes, endothelial cells and other cell types.

Cellex Biosciences, Inc.
Perfusion Technolgies Division, 8500 Evergreen Blvd., Minneapolis, MN 55433, USA
Telephone: (612) 786-0302, Toll free: (800) 325-1112, Fax: (612) 786-0915
URL: http://www.ncc.com

Specialize in in vitro cell culture technologies. Supplies cell culture apparatus, including ResCu-Primer HF and AcuSyst hollow fiber systems. Offer contract services for cell culture and purification from research scale to cGMP large scale production .

The Centre for Biomedical Technology (BMTC)
Faculty of Medical Sciences
University of Groningen
P.O. Box 30.001
9700 RB Froningen, The Netherlands
Telephone +31-50 3614776 or +31 50 3615018, Fax: +31-50 3633113
E-mail: r.m.j.hoedemakers@med.rug.nl

Developed BIAcore an analytical biosensor for measuring interactions between molecules in real time. BIAcore is capable of the following applications: measurement of concentrations in serum and supernatant, affinity constants of antigen-antibody interactions, screening hybridomas for IVD test kits, DNA-protein interactions, functionality of modified proteins or antibodies, optimizing conditions, for column chromatography, screening fractions of protein purifications. Service centre for in vitro diagnostics offers the facility and expertise for production of recombinant proteins, PCR development and PCR-ELISA detection, production of monoclonal and polyclonal antibodies.

CLB Biotechnology Services
Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
Telephone: +31-(0)20-512-3549, Fax: +31-(0)20-512-3550 (from U.S. 31-205123550)

Specialize in contract production of monoclonal antibodies intended for in-vivo application and biosafety testing of biotechnological products. Antibodies produced using in-vitro methods.

Covance Research Products
P.O. Box 7200
Denver, PA 17517, USA
Telephone: (717) 336-4921, Toll free: (800) 345-4114, Fax: (717) 336-5344
E-mail: ab.services@crpinc.com
URL: http://www.crpinc.com

Specialize in custom protocols for monoclonal and polyclonal antibody production. In vivo and in vitro methods used. Services include hybridoma development, peptide synthesis, immunoassay development and testing, ELISA testing, basic primary cell culture testing and antibody characterization, purification, and packaging.

CytRx Corp.
154 Technology Pkwy., Norcross, GA 30092, USA
Telephone: (770) 368-9500,Titermax Telephone: (800)-345-2987, Fax: (770) 447-8875
E-mail: titermax@cytrx.com
URL: http://www.titermax.com

Produces of Titermax®, a synthetic alternative to Freund's adjuvant for monoclonal and polyclonal antibody production.

Cytogen Corp.
600 College Rd., E., Princeton, NJ 08540-5308, USA
Telephone: (609) 987-8200, Fax: (609) 452-2975
E-mail: cytoinfo@corpcomm.cytogen.com
URL for catalog and newsletter: http://www.cytogen.com

Research and development of diagnostic and therapeutic substances such as monoclonal antibodies for cancer patients. Antibodies produced using hollow fiber bioreactors. Antibodies purified to a high purity suitable for in vivo use. Contract manufacturing of antibodies offered.

DiagXotics
27 Cannon Road, Wilton, CT 06897, USA
Telephone: (203) 762-0279, Toll free: (800) 676-2927, Fax: (203) 762-2378
E-mail: john@csni.org

Manufacturers of a simple "No-Mouse" system in which a gas permeable bag is used to grow hybridoma cells for monoclonal antibody production. No special machinery required other than a tissue culture hood, 37C incubator, and a low speed centrifuge.

Eramus Centre for Animal Research (EDC)
Erasmus University (FGG)
P.O. Box 1738, 3000 DR, Rotterdam, The Netherlands
Telephone: +31-(0)10-4087587, Fax: +31-(0)10-4361425 (from U.S. 31-104361425)
E-mail: buro@edc.fgg.eur.nl

Produce monoclonal antibodies in an artificial culture system (Integra Biosciences Technomouse) upon request and for experimental use only. Most monoclonal antibodies produced in protein free medium without the use of serum.

Facilitair Hybridoma Laboratorium
Institute for Infectous Diseases and Immunology
Faculty of Veterinary Medicine
Utrecht University
Yalelaan 1, 3584 CL Utrecht, The Netherlands
Telephone: +31 30 2531872 or /4358, Fax: +31 30 2533555 (from U.S. 31-302533555)
E-mail: p.kooten@vetmic.dgk.ruu.nl or w.eden@vetmic.dgk.ruu.nl

Producers of MoAbs in protein free medium in bulk culture and concentrated by ultra-filtration (30 kD filter). Product has a purity of +/- 80%. Higher percentage purity is available on request.

Fuzhou Maxim Biotech, Inc.
566 Gunyeh Rd.
Fuzhou, Fujian 350002, PR China
E-mail: fzmbi@public.fz.fj.cn
Telephone: +86 591 3732741, Fax: +86 591 3720685
URL: http://www.maximbio.com

Produce the EZInet^TM phage display cDNA library kit which utilizes filamentous phage, M13, to express foreign peptides or proteins.

Goodwin Biotechnology Incorporated
1850 NW 69th Ave., Plantation, FL 33313, USA
Telephone: (954) 321-5300, Fax: (954) 587-6378
E-mail: info@goodwinbio.com
URL: http://www.goodwinbio.com/

GBI is a cGMP compliant contract manufacturer that assists companies developing monoclonal antibodies and recombinant proteins in mammalian cell culture. Our focus is to provide services that our compliant, scalable, and cost effective. GBI is fully integrated and our “fast track” manufacturing strategies have enabled us to deliver vialed product to clients in as little as seven months after transfer of a cell line to GBI. Services offered by GBI include cell line engineering, clone selection, media studies, process development, cell banking, bioreactor production, purification, monoclonal antibody conjugation (and enzymatic digestion) and aseptic filling. These services are offered in support of your fully integrated projects (providing you as close to a turn-key approach as possible in biologics manufacturing) or as stand-alone services. GBI’s manufacturing activities are supported by analytical testing, stability studies, project management, and unparalleled regulatory support. Regulatory support includes preparation of CMC sections for IND applications (or foreign equivalents), and distribution of your product to clinical trial sites.

Harlan Bioproducts for Science, Inc.
P.O. Box 29176
Indianapolis, IN 29176, USA
Telephone: (317) 894-7536, Toll free: (800) 972-4362, Fax: (317) 894-1840
E-mail: hbps@harlan.com
URL: http://www.harlan.com/hbps2.htm

Specialize in the custom production of polyclonal and monoclonal antibodies, in vivo and in vitro. Offer cGMP and non-cGMP production, hybridoma development, MAP testing, purification, endotoxin testing and other immunological services.

IDEC Pharmaceuticals Corp.
11011 Torreyana Rd.
San Diego, CA 92121, USA
Telephone: (619) 550-8500, Fax: (619) 550-8750
E-mail: info@idecpharm.com
URL: http://www.idecpharm.com (under construction)

Research and development of monoclonal antibodies. Phage display technologies investigated. Alternative adjuvant ProVax used in cancer studies. Large scale antibody production.

ImmuCell Corp.
56 Evergreen Dr., Portland, ME 04103-1066, USA
Telephone: (207) 878-2770, Fax: (207) 878-2117

Develop and manufacture cow milk-derived passive antibody products. Rabbits and cows used for polyclonal antibody production. Tissue cultures used in vaccine development. Applications include a product to prevent scours in calves and others to prevent human gastrointestinal infections.

Institute of Laboratory Animal Science
University of Zurich
Winterthurerstrasse 190, 8057 Zurich, Switzerland
Telephone: +41 1 257 54 52, Fax: +41 1 257 57 03 (from U.S. 41-1257575703)
E-mail: frhom@ltk.unizh.ch
URL: http://www.unizh.ch/labtier/

Generate MAB in various sized hollow fiber bioreactors and roller bottles. Hybridoma lines can be sub-cloned to increase yields if necessary. Customers receive the required amount of MAB as a crude bioreactor harvest. FCS-free culture available if the hybridoma line has previously been adapted to this condition by the customer.

INTEGRA Biosciences (Multiple Addresses)

INTEGRA Biosciences AG P.O. Box 74, CH-8304, Wallisellen, Switzerland Telephone: (41) +1 8 77 46 46, Telefax: (41) +1 877 46 00 E-mail: info-ch@integra-biosciences.com INTEGRA Biosciences AG P.O. Box 74, CH-8304, Wallisellen, Switzerland Telephone: (41) +1 8 77 46 46, Telefax: (41) +1 877 46 00 E-mail: info-ch@integra-biosciences.com INTEGRA Biosciences GmbH Ruhberg 4, D-35463 Fernwald, Germany Telephone: (49) 6404 80 90, Telefax: (49) 6404 58 65 E-mail: info@integra-biosciences.com INTEGRA Biosciences S.a.r.l. 4, rue de lendemain, B.P. 8886, F-95898 Cergy le Haut Cedex, France Telephone: (33) 1 3446 7171, Telefax: (33) 1 3446 7179 E-mail: info-f@integra-biosciences.com INTEGRA Biosciences Ltd. Unit 9, Ascot Industrial Estate, Icknield Way, Letchworth, UK-Hertfortshire, SG6 1TD Telephone: (44) 1462 48 65 48, Telefax: (44) 1462 48 66 78 E-mail: info-uk@integra-biosciences.com INTEGRA Biosciences Inc. 10097 Tyler Place, Suite 10, Ijamsville, MD 21754, USA Telephone: 1 (301) 874-5790, Telefax: 1 (301) 874-5799 E-mail: info-usa@integra-biosciences.com Web Page: http://www.integra-biosciences.com The TECNOMOUSE, a hollow fiber "in vitro" system, has been used successfully for years for the production of monoclonal antibodies and for the expression of cell products. In this system, separation of cultivation and nutrient/oxygenation chambers is via hollow fibers in combination with membranes through which gases may diffuse. Optimal media utilization, direct oxygenation and yields of up to 500 mg of monoclonal antibody per month are possible. In the same unit up to five different cell lines can be cultivated at the same time. TECNOMOUSE truly is an alternative to the production Mab in mice. CELLine, a compartementalized cell culture system based on membrane technology, is another product in INTEGRA's line of alternative cell cultivation products that has just been released. This system can cultivate up to 108mg of Mab per month. The membrane technology greatly reduces the serum consumption and especially the time spent for purfication. The CELLine is available in three different sizes, is disposable, efficient and cost effective. A recently published article in the Scientist magazine describes the advantages of this system.

Lampire Biological Laboratories, Inc.
P.O. Box 270, Pipersville, PA 18947, USA
Telephone: (215) 795-2838, Fax: (215) 795-0237
E-mail: lampire@lampire.com
URL: http://www.lampire.com

Develops and produces monoclonal and polyclonal antibodies. Uses ascites production and bioreactor technologies. Catalog available. Monoclonal animal models include mice, rats, and hamsters. Polyclonal animal models are rabbits, chickens, goats, sheep, and donkeys. Custom antibodies can be designed and produced using rats, cows, guinea pigs, and horses.

Lazar Research Laboratories, Inc.
731 North La Brea Avenue Suite 5
Los Angeles, CA 90038, USA
Telephone: (213) 931-1204 or 001-213- 931-1204 (outside U.S.),Toll free: (800) 824-2066, Fax: (213) 931-1434 (outside U.S. and Canada, dial 001 country code before the Telephone number)
E-mail: service@lazarlab.com
URL: http://www.lazarlab.com/biotech.htm

Offer the Ultra M Micro Bioreactor System for sale. Can convert standard six well cultura plate or T-flasks into a continuous flow bioreactor system.

Maine Biotechnology Services, Inc.
1037R Forest Avenue, Portland, ME 04103, USA
Telephone: (207) 797-5454, Fax: (207) 797-5595
E-mail: mainbio@maine.com

Produces customized monoclonal and polyclonal antibodies for diagnostic companies and researchers. Several hundred antibodies are listed in the catalog. Bioreactors and mice are used for monoclonal production. Polyclonal antibodies are produced from sheep, goats, and rabbits.

National Institute of Public Health and the Environment (RIVM)
Laboratory for the Control of Biological Products (LCB)
P.O. Box 1, 3720 BA, Bilthoven, The Netherlands
Telephone: +31 30 2743697, Fax: +31 30 2744420 (from the U.S. 31-302744420)
E-mail: Mia.Leerling@RIVM.nl

Available to provide information on in vitro production of monoclonal antibodies. Knowledge of cell culture, roller bottle, and hollow fiber system technologies.

New England Biolabs, Inc.
32 Tozer Road
Beverly, MA 01015, USA
Telephone: (508) 927-5054, Toll free: (800) 632-7799, Fax: (508) 921-1350
E-mail: info@neb.com
URL: http://www.neb.com/nebecomm/default.asp

Offer phage display peptide library kits displayed on bacteriophage M13.

Office of Biotechnology
Iowa State University
Ames, Iowa 50011-3260, USA
Telephone: (515) 294-2472, Fax: (515) 294-0453
E-mail: kharkins@iastate.edu or clap@iastate.edu
URL: http://www.biotech.iastate.edu/facilities/CELLHYB/homepage.htm

Offer bulk monoclonal antibody production in bioreactors or ascites production in mice.

Paul-Ehrlich-Institut
Federal Agency for Sera and Vaccines
Department of Veternary Medicine
Paul-Ehrlich-Straße 51-59
D-63225 Langen Neurott, Germany
Telephone: (49) 6103-77/77-0, Fax: (49) 6103/77-123 (from U.S. 49-610377123)
E-mail: peiyup@em.uni-frankfurt.de
URL: http://www.rz.uni-frankfurt.de/~peiski/

Research conducted on alternative adjuvants for vaccine development and research immunizations with little side effects.

QED Bioscience
11021 Via Frontera #203, San Diego, CA 92127, USA
Telephone: (619) 675-2405, Toll free: (800) 929-2114 or , Fax: (619) 592-1509
URL: http://www.qedbio.com

Develops and supplies monoclonal and polyclonal antibodies to an extensive range of antigens for research laboratories and healthcare industry. Offers custom antibody development (monoclonal and polyclonal), ascites production, and in vitro antibody production services. New products include culture media for hybridomas, immunoassay kits, ascites production kits, and hybridoma development kits.

Ribi ImmunoChem Research, Inc.
553 Old Corvallis Road, Hamilton, MT 59840, USA
Telephone:(406) 363-6214, Toll free: (800) 548-7424, Fax: (406) 363-6129
E-mail: general@ribi.com

Manufactures the Ribi Adjuvant System (RAS). RAS is appropriate for use in a variety of laboratory animals such as mice, rats, guinea pigs, rabbits, goats and non-human primates. Independent comparative studies have shown that RAS is an effective adjuvant without the toxic side effects associated with the use of Freund's adjuvant.

Scantibodies Laboratory, Inc.
9336 Abraham Way
Santee, CA 92071, USA
Telephone: (619) 258-9300, Fax: (619) 258-9366
E-mail: cs@scantibodies.com
URL: http://www.scantibodies.com

Offer custom in vitro monoclonal antibody production using a variety of bioreactors. Ascites production in mice.

Spectrum® U.S. Headquarter
23022 La Cadena Drive
Laguna Hills, CA 92653-1352, USA
E-mail: techsupport@spectumlabs.com
Telephone: (714) 58-3500 or toll free 1-(800) 654-0111, Fax: (714) 855-6120
URL: http://www.spectrapor.com

Spectrum® has merged with Cellco, Inc. (see Cellco), makers of an artificial capillary system for in vitro production of monoclonal antibodies, proteins, and viruses. Spectrum is a supplier of dialysis and ultrafiltration membranes used for biomedical research, molecular biology, and clinical diagnostics.

Serologicals Corp.
780 Park North Blvd., #110, Clarkston, GA 30021, USA
Telephone: (404) 296-5595, Fax: (404) 296-0052

Provides monoclonal and polyclonal antibodies to pharmaceutical companies that develop diagnostics. Locate and recruit antibodies for use as test kit controls. Antibodies are human subject derived such as rabies immunoglobulin and hepatitis A and B.

Sierra BioSource, Inc.
1180-C Day Rd., Gilroy, CA 95020-9308, USA
Telephone: (408) 847-5444, Fax: (408) 847-5044
E-mail: antibody@garlic.com

Produces cell lines for clients. Uses some in vitro techniques for monoclonal antibody production. Monoclonal models include mice, rats, and humans. Polyclonal antibodies produced on demand from rats, rabbits, and guinea pigs.

TNO Prevention and Health
Immunological and Infectious Diseases
P.O. Box 2215, 2301 CE, Leiden, The Netherlands
Telephone: +31.71.518.1431, Fax: +31.71.518.1901 (from U.S. 31-715181901)
E-mail: nd.zegers@pg.tno.nl

Offer complete services to obtain suitable site-specific poly- and monoclonal antibodies using antigen or synthetic peptides including: selection of epitopes, synthesis of peptides, construction of peptide conjugates for immunization, and development of selection assays. MAbs are produced using in vitro methods.

Unisyn Technologies Inc.
25 South St., Hopkinton, MA 01748, USA
Telephone: (508) 435-2000, Toll free: (800)-4UNISYN, Fax: (508) 435-8111
E-mail: unisyn@unisyntech.com
URL: http://www.unisyntech.com

Manufacture hollow fiber bioreactor instruments and accessories and protein purification products for monoclonal antibodies and recombinant protein production. GMP contract service facility for clients on a research or full outsourced basis.

Zonagen, Inc.
2408 Timberloch Place, B4
The Woodlands, TX 77380, USA
E-mail: zonasci@infohwy.com
Telephone: (281) 367-5892 or toll free 1-888-448-4837, Fax: (281) 363-8796

Producers of Z-max^TM and ImmuMax ^SR, alternatives to Freund's adjuvants. Z-max^TM was designed specially for use with HIS tagged recombinant proteins, while ImmuMax ^SR was developed to elicit lasting titers to both native and recombinant proteins as well as synthetic peptides.