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Developmental Synaptic Plasticity Section - Publications |
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Terashima, A., Pelkey, K.A., Rah, J., Suh, Y., Roche, K.W., Collingridge, G.L., McBain, C.J. and Isaac, J.T.R. (2008) An essential role for PICK1 in NMDA receptor-dependent bidirectional synaptic plasticity, Neuron.
Daw, M.I., Ashby, M.C. and Isaac, J.T.R (2007) Coordinated recruitment of latent fast spiking interneurons into the layer IV barrel cortex circuit enables rapid development of thalamocortical feed forward inhibition, Nature Neurosci 10, 453-461.
Daw, M.I., Scott, H.L. and Isaac, J.T.R (2007) Developmental synaptic plasticity at the thalamocortical input to barrel cortex: mechanisms and roles, Molecular and Cellular Neuroscience 34, 493-502.
Isaac, J.T.R., Ashby, M. and McBain, C.J (2007) The role of the GluR2 subunit in AMPA receptor function and synaptic plasticity, Neuron 54, 859-871.
Daw, M.I., Bannister, N.J. and Isaac, J.T.R. (2006) Rapid, activity-dependent plasticity of timing precision in neonatal barrel cortex, J.Neurosci. 26, 4178-4187.
Plant, K., Pelkey, K.A., Bortolotto, Z.A., Morita, D., Terashima, A., McBain, C.J., Collingridge, G.L. and Isaac, J.T.R. (2006) Transient incorporation of GluR2-lacking AMPA receptors during hippocampal long-term potentiation, Nature Neurosci. 9, 602-604.
Lauri, S.E., Vesikansa, A., Segerstrale, M., Collingridge, G.L., Isaac, J.T.R. and Taira, T. (2006) Developmental and activity-dependent regulation of tonically activated presynaptic kainate receptors at CA1 synapses in neonatal hippocampus, Neuron 50, 415-429.
Nasu-Nishimura, Y., Hurtado, D., Braud, S., Tang, T.T., Isaac, J.T.R. and Roche, K.W. (2006) Identification of an ER-retention motif in an intracellular loop of the kainate receptor subunit KA2, J. Neurosci 26, 7014-7021.
Park, Y., Jo, J., Isaac, J.T.R. and Cho, K. (2006) Long-term depression of kainate receptor-mediated synaptic transmission, Neuron 49, 95-106.
Lim, W. and Isaac J.T.R. (2005) ATP hydrolysis is required for the rapid regulation of AMPA receptors during basal synaptic transmission and long-term synaptic plasticity. , Neuropharmacology 48, 949-955.
Lauri, S.E., Segerstrale, M., Vesikansa, A., Maingret, F., Collingridge, G.L., Isaac, J.T.R. and T. Taira. (2005) Endogenous activation of kainate receptors regulate glutamate release and network activity in the developing hippocampus., Journal of Neuroscience 25, 4473-4484.
Bannister, N.J., Benke, T.A., Mellor, J., Gurdal, E., Crabtree, J.W. and Isaac, J.T.R. (2005) Developmental changes in AMPA and kainate receptor-mediated quantal transmission at thalamocortical synapses in the barrel cortex., Journal of Neuroscience 25, 5259-5271.
Kim, C.H., Braud, S., Isaac, J.T.R. and Roche, K.W. (2005) PKC phosphorylation of the metabotropic glutamate receptor mGluR5 on serine 839 regulates Ca2+ oscillations., J.Biol. Chem. 280, 25409-25415.
Maingret, F., Lauri, S.E., Taira, T. and Isaac J.T.R. (2005) Profound regulation of neonatal CA1 rat hippocampal GABAergic transmission by functionally distinct kainate receptor populations., Journal of Physiology 567, 143-157.
Palmer, C.L., Lim, W., Hastie, P., Toward, M., Korolchuk, V.I., Burbidge, S.A., Banting, G., Collingirdge, G.L., Isaac, J.T.R. and Henley, J.M. (2005) Hippocaclin functions as a calcium sensor in hippocampal LTD., Neuron 47, 487-494.
Isaac, J.T.R., Mellor, J., Hurtado, D and Roche, K.W. (2004) Kainate receptor trafficking: physiological roles and molecular mechanisms, Pharmacology and Therapeutics 104, 163-172.
Terashima, A., Cotton, L., Dev, K.K., Meyer, G., Zaman, S., Duprat, F., Henley, J.M., Collingridge, G.L. and Isaac, J.T.R. (2004) Regulation of synaptic strength and AMPA receptor subunit composition by PICK1. , J. Neurosci 24, 5381-5390.
Collingridge, G.L., Isaac, J.T.R. and Wang, Y-T. (2004) Receptor trafficking and synaptic plasticity, Nature Reviews Neuroscience 5, 952-962.
Palmer, M.J., Isaac, J.T.R. and Collingridge, G.L. (2004) Multiple, developmentally-regulated expression mechanisms of LTP at CA1 synapses, J. Neurosci 24, 4903-4911.
Luthi, A., Wikstrom, M.A., Palmer, M.J., Matthews, P., Benke, T.A., Isaac, J.T.R. and Collingridge, G.L. (2004) Bi-directional modulation of AMPA receptor unitary conductance by synaptic activity., BMC Neuroscience 5, 44.
Hirbec, H., Francis, J.C., Lauri, S.E., Braithwaite, S.B., Coussen, F., Mulle, C., Dev, K.K., Couthino, V., Meyer, G., Isaac, J.T.R., Collingridge, G.L. and Henley, J.M. (2003) Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP, Neuron 37, 625-638.
Duprat, F., Daw, M. I., Lim, W., Collingridge, G.L. and Isaac J.T.R. (2003) GluR2 protein-protein interactions and the regulation of AMPA receptors during synaptic plasticity, Proc. R. Soc. Lond. B. 358, 715-720.
Collingridge, G.L. and Isaac, J.T.R. (2003) Functional roles of protein interactions with AMPA and kainate receptors, Neurosci. Res 47, 3-15.
Lauri, S.E., Bortolotto, Z.A., Bleakman, D., Ornstein, P.L., Lodge, D., Isaac, J.T.R. and Collingridge, G.L. (2003) A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus. , Neuron 39, 327-341.
Isaac, J.T.R. (2003) Postsynaptic silent synapses: Evidence and mechanisms, Neuropharmacology 45, 450-460.
Hayes, D., Braud, S., Hurtado, D., McCallum, J., Standley, S., Isaac, J.T.R. and Roche, K.W. (2003) Trafficking and surface expression of the glutamate receptor subunit, KA2. , Biochem. Biophys. Res. Commun. 310, 8-13.
Bortolotto, Z. A., Lauri, S., Isaac, J.T.R. and Collingridge, G.L. (2003) Kainate receptors and the induction of mossy fibre LTP, Proc. R.. Soc. Lond. B. 358, 657-666.
Molnar, E. and Isaac, J.T.R. (2002) Developmental and activity dependent regulation of ionotropic glutamate receptors at synapses, TheScientificWorldJournal 2, 27-47.
Kidd, F.L., Coumis, U., Collingridge, G.L., Crabtree, J.W. and Isaac, J.T.R. (2002) A kainate autoreceptor is involved in regulating the dynamic properties of thalamocortical synapses during development. , Neuron 34, 635-646.
Crabtree, J.W. and Isaac, J.T.R. (2002) New intrathalamic pathways allowing modality-related and cross-modality switching in the dorsal thalamus, J. Neurosci 22, 8754-8761.
Kidd, F.L., Coumis, U., Collingridge, G.L., Crabtree, J.W. and Isaac, J.T.R. (2002) A kainate autoreceptor is involved in regulating the dynamic properties of thalamocortical synapses during development., Neuron 34, 635-646.
Daw, M.I., Bortolotto, Z.A., Saulle, E.M.G., Zaman, S., Collingridge, G.L. and Isaac, J.T.R. (2002) Phosphatidylinositol 3 kinase regulates the specificity of hippocampal LTD. , Nature Neurosci 5, 835-836.
Benke, T.A., L�thi, A., Palmer, M.J., Wikstr�m, M., Anderson, W.W., Isaac, J.T.R. and Collingridge, G.L. (2001) Mathematical modeling of non-stationary fluctuation analysis of synaptic AMPA receptors in branched structures, J.Physiol. (London) 537, 407-420.
Lauri, S.E., Bortolotto, Z.A., Bleakman, D., Ornstein, P.L., Lodge, D., Isaac, J.T.R. and Collingridge, G.L. (2001) A critical role of a facilitatory kainate autoreceptor in mossy fibre LTP., Neuron 32, 697-709.
Lauri, S.E., Delaney, C., Clarke, V., Bortolotto, Z.A., Ornstein, P.L., Isaac, J.T.R. and Collingridge, G.L. (2001) Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses, Neuropharmacology 41, 907-915.
Isaac, J.T.R. (2001) Protein phosphatases and LTD: synapses are the architects of depression, News & views for Neuron 32, 963-966.
Kidd, F.L. and Isaac, J.T.R. (2001) Kinetics and activation of postsynaptic kainate receptors at thalamocortical synapses: role of glutamate clearance., J.Neurophysiol 86, 1139-1148.
Kidd, F.L. and Isaac, J.T.R. (2000) Glutamate transport blockade has a differential effect on AMPA and NMDA receptor-mediated synaptic transmission in the developing barrel cortex. , Neuropharmacology 39, 725-732.
Daw, M.I., Chittajallu, R., Bortolotto, Z.A., Dev, K.K., Duprat, F., Henley, J.M., Collingridge, G.L. and Isaac, J.T.R. (2000) PDZ proteins interacting with c-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. , Neuron 28, 873-886.
Hjelmstad, G.O., Isaac, J.T.R., Nicoll, R.A. and Malenka, R.C. (1999) Lack of AMPA receptor desensitization during basal synaptic transmission in the hippocampal slice. , J.Neurophysiol. 81, 3096-3099.
L�thi, A., Chittajallu, R., Duprat, F., Palmer, M.J., Benke, T.A., Kidd, F.L., Henley, J.M., Isaac, J.T.R and Collingridge, G.L. (1999) Hippocampal LTD expression involves a pool of AMPA receptors regulated by the NSF-GluR2 interaction., Neuron 24, 389-399.
Fox, K.D., Henley, J.M. and Isaac, J.T.R. (1999) Experience-dependent development of NMDA receptor transmission, News & views for Nature Neuroscience 2, 297-299.
Kidd F.L. and Isaac J.T.R. (1999) Developmental and activity-dependent regulation of kainate receptors at thalamocortical synapses, Nature 400, 569-573.
Isaac, J.T.R., Nicoll, R.A. and Malenka, R.C. (1999) Silent glutamatergic synapses in the mammalian brain, Can. J. Physiol Pharmacol 77, 735-737.
Benke, T.A., L�thi, A., Isaac, J.T.R. and Collingridge, G.L. (1998) Modulation of AMPA receptor unitary conductance by synaptic activity. , Nature 393, 793-797.
Crabtree, J.W., Collingridge, G.L. and Isaac, J.T.R. (1998) A new intrathalamic pathway linking modality-related nuclei in the dorsal thalamus. , Nature Neuroscience 1, 389-394.
Nishimune, A., Isaac, J.T.R.*, Molnar, E., Noel, J., Nash, S.R., Tagaya, M., Collingridge, G.L., Nakanishi, S. and Henley, J.M. (1998) NSF binding to GluR2 regulates synaptic transmission., Neuron 21, 87-97.
Feldman, D.E., Nicoll, R.A., Malenka, R.C. and Isaac, J.T.R. (1998) Long-term depression at thalamocortical synapses in developing rat somatosensory cortex. , Neuron 21, 347-357.
Isaac, J.T.R., L�thi, A., Palmer, M.J., Anderson, W.W., Benke, T.A. and Collingridge, G.L. (1998) An investigation of the expression mechanism of LTP of AMPA receptor-mediated synaptic transmission at hippocampal CA1 synapses using failures analysis and dendritic recordings. , Neuropharmacology 37, 1399-1410.
Turner, D.A., Chen, Y., Isaac, J.T.R., West, M. and Wheal, H.V. (1997) Excitatory synaptic site heterogeneity during paired pulse plasticity in CA1 pyramidal cells in the rat hippocampus in vitro. , J.Physiol.(London) 500, 441-461.
Isaac, J.T.R., Crair, M.C., Nicoll, R.A. and Malenka, R.C. (1997) Silent synapses during development of thalamocortical inputs. , Neuron 18, 269-280.
Isaac, J.T.R, Hjelmstad, G.O., Nicoll, R.A. and Malenka, R.C. (1996) Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells. , Proc. Natl. Acad. USA 93, 8710-8715.
Isaac, J.T.R, Oliet, S.H.R, Hjelmstad, G.O., Nicoll, R.A. and Malenka, R.C. (1996) Expression mechanism of long-term potentiation in the hippocampus, J. Physiol. (Paris) 90, 299-303.
Isaac, J.T.R, Nicoll, R.A. and Malenka, R.C. (1995) Evidence for silent synapses: implications for the expression of LTP., Neuron 15, 427-434.
Isaac, J.T.R. and Wheal, H.V. (1993) The local anaesthetic QX-314 enables enhanced whole-cell recordings of excitatory synaptic currents in rat hippocampal slices in vitro. , Neurosci. Lett. 150, 227-230.
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