June K. Dunnick, Ph.D., is a toxicologist in the Toxicology Branch, which promotes, designs and administers research programs to understand how environmental exposures affect the public’s health. Research is focused on identifying and evaluating the benefical and harmful effects of environmental chemicals, drugs, metals and other chemicals of concern so that strategies can be developed to prevent exposures to harmful agents or to develop treatment strategies particularly for cancer, reproductive disease, and infectious diseases. This involves the design, analysis, and interpretation of experimental studies to identify biological effects, and extrapolation of results to man through the use metabolism/pharmacokinetic studies and mechanistic studies. Her responsibilities include serving as senior scientist for toxicologic and carcinogenesis studies and identifying new initiatives for the development of a better understanding of environmental disease, through the integration, extrapolation and analysis of data from a broad range of experimental studies. She also serves as a focus, representative and spokesperson for the Institute when reporting the findings from toxicology and carcinogenesis research studies.
Dunnick received a B.S. from Cornell University, Ithaca, New York and a Ph.D. from Cornell University Medical College, New York, New York. She completed postdoctoral work in the Department of Biochemistry, University of Rochester Medical School, Rochester, New York.
Lea IA, Jackson MA, Li X, Bailey S, Peddada SD, Dunnick JK. (2007) Genetic pathways and mutation profiles of human cancer: site- and exposure-specific patterns. Carcinogenesis 9: 1851-1858. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17693665)
Dunnick, J. K., Thayer, K. A., Travlos, G. S. (2007) Inclusion of biomarkers for detecting perturbations in the heart and lung and lipid/carbohydrate metabolism in National Toxicology Program studies. Toxicological Sciences 100:29-35. [Abstract](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17490986)
Dunnick, J. K., Heath, J. E., Farnell, D. R., Prejean, J. D., Haseman, J. K. Elwell, M. R. (1997) Carcinogenic activity of brominated chemicals: studies with the flame retardant, 2,2-bis(bromomethyl)-1,3-propanediol in rodents, and comparison with the carinogenity of other brominated chemicals. Toxicologic Pathology 25:541-548.
Dunnick, J. K. and Hailey, J. R. (1996) Phenolphthalein exposure causes multiple carcinogenic effects in experimental model systems. Cancer Research 56: 4922-4926.
Elwell, M. R. , J. K. Dunnick. R. Hailey, and J. Haseman. (1996) Decreases in the incidence of Fisher rat leukemia. Toxicologic Pathology 24: 238-245.
Dunnick, J. K., Elwell, M. R., Haseman, J. K. (1996) Decreased incidence of spontaneous mammary gland neoplasms in female F344 rats treated with amphetamine, methylphenidate, or codeine. Cancer Letters 102: 1-7.
Dunnick, J. K., Elwell, M.R., Radovsky, A.E., Benson, J.M., Hahn, F.F., Barr, E.B., Hobbs, C.H. (1995) Comparative carcinogenic effects of nickel subsulfide, nickel oxide, or nickel sulfate hexahydrate exposures in the lung. Cancer Research 55:5251-5256.
Dunnick, J.K., Elwell, M.R., Huff, J. and Barrett, J.C. (1995) Experimental studies of mammary gland cancer and environmental chemicals. Carcinogenesis 16:173-179.
Dunnick, J. K. and Hailey, R. (1995) Experimental studies on the long-term effects of methylphenidate hydrochloride. Toxicology 103: 77-84.
Dunnick, J.K., Elwell, M.R. and Bucher, J. (1994) Comparative toxicity of o-, m-, and p-nitrotoluene in 13-week feed studies in F344 rats and B6CF1 mice. Fund. Appl. Toxicol. 22:411-421.
Yuan, J., Dunnick, J.K., Jones, E.C. and Findlay, J.W.A. (1994) Codeine toxicokinetics in rats during 2-year dosed feed study. Drug Metabolism and Disposition 22:14-20.
Morgan, D.L., Dunnick, J.K., Goehl, T., Jokinen, M.P., Matthews, H.B., Zeiger, E. and Mennear, J. H. (1994) Summary of the National Toxicology Program Benzidine Dye Initiative. Environmental Health Perspectives 102:63-78.
Dunnick, J.K. and Melnick, R.L. (1993) Assessment of the carcinogenic potential of chlorinated water: experimental studies of chlorine, chloramine, and trihalomethanes. J. Natl. Cancer Inst. 85:817-822.