Patey O, Meyrin E, Malkin JE, Prazuck T, Dublanchet A, Lafaix C; International Conference on AIDS.
Int Conf AIDS. 1993 Jun 6-11; 9: 356 (abstract no. PO-B08-1325).
CHI Villeneuve Saint Georges.
Loss of antibodies against hepatitis C virus in HIV seropositive patients have been reported. On the other hand, HIV patients have an increase of total immunoglobins in evolutive disease. We have tested 25 HIV and HCV coinfected patients for HCV RIBA2, P24 antigen and antibodies, aminotransferases, immunoglobulins, HBs antigen, CD4 and CD8 lymphocytes counts. They all have more than 3 tests during 3 years. All were IV drug users except three patients with posttransfusional HIV infection. Mean age was 31 years. All RIBA 2 tests confirmed HCV infection. One patient was coinfected with HBVirus. We found no correlation between O.D. value and the number and intensity of the bands on the RIBA2. 12 had CD4 count more than 350/mm3 in all tests, 8 always under 350/mm3 and 5 had decreased of CD4 lymphocytes counts. Two patients had normal aminotransferases. We found no correlation between all covariables and HCV antibodies on RIBA 2 in each patient except one with HIV post-transfusional infection who lost most of the bands on RIBA2. One patient dead with liver cirrhosis and toxoplasmic infection. PCR were never performed but two patients including one with persistent normal aminotransferase levels had liver biopsy showing chronic hepatitis. In conclusion we haven't observed any variation in the HCV RIBA 2 profiles in HIV positive patients during the HIV diseases with or without fatal progression.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- CD4-Positive T-Lymphocytes
- Disease Progression
- HIV
- HIV Antibodies
- HIV Core Protein p24
- HIV Infections
- HIV Seronegativity
- HIV Seropositivity
- Hepacivirus
- Hepatitis C Antibodies
- Hepatitis, Chronic
- Humans
- Substance Abuse, Intravenous
- immunology
Other ID:
UI: 102204240
From Meeting Abstracts