Phase I: Preconditioning
|
Oral infections: dental caries, endodontic infections, periodontal disease (gingivitis, periodontitis), mucosal infections (i.e., viral, fungal, bacterial). |
Gingival leukemic infiltrates. |
Metastatic cancer. |
Oral bleeding. |
Oral ulceration: aphthous ulcers, erythema multiforme. |
Temporomandibular dysfunction. |
Phase II: Conditioning Neutropenic Phase |
Oropharyngeal mucositis. |
Oral infections: mucosal infections (i.e., viral, fungal, bacterial), periodontal infections. |
Hemorrhage. |
Xerostomia. |
Taste dysfunction. |
Neurotoxicity: dental pain, muscle tremor (e.g., jaws, tongue). |
Temporomandibular dysfunction:
jaw pain, headache, joint pain. |
Phase III: Engraftment
Hematopoietic Recovery |
Oral infections: mucosal infections (i.e., viral, fungal, bacterial). |
Acute GVHD.
|
Xerostomia.
|
Hemorrhage. |
Neurotoxicity:
dental pain,
muscle tremor (e.g., jaws, tongue).
|
Temporomandibular dysfunction: jaw pain, headache, joint pain. |
Granulomas/papillomas. |
Phase IV: Immune
Reconstitution
Late Posttransplant |
Oral infections: mucosal infections (i.e., viral, fungal, bacterial). |
Chronic GVHD. |
Dental/skeletal growth and development
alterations (pediatric patients). |
Xerostomia. |
Relapse-related oral lesions. |
Second malignancies. |
Phase V: Long-term Survival |
Relapse or second malignancies. |
Dental/skeletal growth and development
alterations. |