Oral mucositis |
Mucosal cytotoxicity |
Decreased local/systemic immunity: local infections, reactivation of HSV |
Physical/chemical trauma |
Oral infections: |
|
|
Viral |
|
Decreased systemic immunity |
Fungal |
|
Decreased systemic immunity |
Salivary gland dysfunction |
Altered oral flora (decreased
bacterial flora) |
Bacterial |
Inadequate oral hygiene |
Decreased systemic immunity |
Mucosal breakdown |
Salivary gland dysfunction |
Acquired pathogens |
Taste dysfunction |
Taste receptor toxicity |
|
Xerostomia |
Salivary gland toxicity |
Anticholinergic drugs |
Neuropathies |
Vinca alkaloid drug use; specific drug toxicity |
Anemia, dental hypersensitivity, temporomandibular dysfunction/myofascial pain |
Dental and skeletal growth and development (pediatric patients) |
Specific drug toxicity |
Stage of dental and skeletal maturation |
Gastrointestinal mucositis causing secondary changes in oral status including taste, hygiene, and dietary intake |
Mucosal cytotoxicity: radiation, chemotherapy |
Nausea and vomiting |
Hemorrhage |
Oral mucositis
|
Thrombocytopenia |
Physical trauma |
Decreased clotting factors (e.g., DIC) |
Infections (e.g., HSV) |