Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsors and Collaborators: |
Assuta Hospital Systems Maccabi |
---|---|
Information provided by: | Assuta Hospital Systems |
ClinicalTrials.gov Identifier: | NCT00449345 |
The ministry of health in Israel requires all health-care workers to undergo screening for latent Tuberculosis infection (LTBI) prior to starting work. This is based on the Mantoux skin test, which is notoriously unreliable.
In recent years, more specific and sensitive tests based on interferon-gamma secretion to TB antigens have come to market, and most current evidence shows that many mantoux positive persons do not have LTBI. Quantiferon-GOLD is one of these assays.
In this prospective study, we will draw blood for the Quantiferon-GOLD assay in parallel to conventional testing, and perform a cost-effectiveness analysis of the cost of the investigation and treatment of LTBI in health-care workers.
We hypothesize that in spite of the cost of screening healthcare workers with Quantiferon-GOLD tests, the reduction in need for LTBI treatment and associated costs will render the test cost-effective.
Condition | Intervention |
---|---|
Latent Tuberculosis Infection |
Procedure: Blood test for Quantiferon-GOLD assay |
Study Type: | Observational |
Study Design: | Screening, Longitudinal, Defined Population, Prospective Study |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: David Shitrit, MD | +972 8 946 8617 | david_s@mac.org.il |
Contact: Ben Fox, MRCP | +972 8 946 8617 | fox_b@mac.org.il |
Israel | |
Community Tuberculosis service | Recruiting |
Rehovot, Israel |
Principal Investigator: | David Shitrit, MD | Maccabi Health Services |
Study ID Numbers: | 2006055 |
Study First Received: | March 19, 2007 |
Last Updated: | May 28, 2007 |
ClinicalTrials.gov Identifier: | NCT00449345 |
Health Authority: | Israel: Ministry of Health |
Latent tuberculosis infection Health care workers Tuberculin skin test Mantoux skin test |
Interferon gamma Quantiferon Cost effectiveness |
Bacterial Infections Gram-Positive Bacterial Infections Interferon Type II Interferons |
Mycobacterium Infections Tuberculosis Interferon-gamma, Recombinant |
Infection Actinomycetales Infections |