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Immunopathology Section

Ocular inflammatory models

Ocular tumor model

Genetic targeted models with ocular findings

Age related macular degeneration (AMD)

Age-related macular degeneration (AMD) is a leading cause of visual impairment in the developed countries. The etiology and pathogenesis of AMD remain unknown, however, there is a complex interaction between genetic and environmental factors. Genetic variance analysis has become an attractive tool in the exploration of the genetic component of complex diseases such as AMD. Our main interests are molecular pathology, immunopathology, associations between AMD and various genetic polymorphisms, and animal models of the disease.

fundus photo of hemorrhage from wet AMD
Fundus photo of hemorrhage from wet AMD		   fundus photo of dry AMD
Fundus photo of dry AMD
 
slide showing choroidal neovascularization from AMD
Photomicrograph showing choroidal neovascularization from AMD		   slide showing loss of photoreceptors and RPE change from dry AMD
Photomicrograph showing loss of photoreceptors and RPE change from dry AMD

 

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NEI Website Header Description: Confocal image of rat RPE layer two weeks after laser. A well-defined neovascular membrane labeled with Isolectin Ib4 (red) is detected below proliferating RPE cells (Phalloidin in green). New vessels are growing toward the subretinal space.