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Clinical Neurocardiology Section

David S. Goldstein, M.D., Ph.D., Senior Investigator
Dr. Goldstein graduated from Yale College and received an M.D.-Ph.D. in Behavioral Sciences from Johns Hopkins. After medical internship and residency at the University of Washington, he came to the NIH as a Clinical Associate in the NHLBI, obtaining tenure as a Senior Investigator in 1984. He joined the NINDS in 1990 to head the Clinical Neurochemistry Section and founded and directs the Clinical Neurocardiology Section, an independent Section. He has received Yale's Angier Prize for Research in Psychology, the Laufberger Medal of the Czech Academy of Sciences, 2 NIH Merit Awards, the Founders Award of the Bakken Heart-Brain Institute, and the NIH Distinguished Clinical Teacher Award. He is author of more than 450 research articles and several books, including "Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine," the "NDRF Handbook for Patients with Dysautonomias," "Stress, Catecholamines, and Cardiovascular Disease," and "The Autonomic Nervous System in Health and Disease.

Staff:

• Nelson Cole, Ph.D., Contractor, 301-435-8721 ncole@mail.nih.gov
• Courtney Holmes, C.M.T., Biologist, 301-496-7832 holmesc@ninds.nih.gov
• Tereza Jenkins, Secretary/Patient Care Coordinator, 301-496-1115 jenkinst@ninds.nih.gov
• Irwin J. Kopin, M.D., Scientist Emeritus, 301-496-4297 kopini@ninds.nih.gov
• Neptune Mizrahi, Ph.D., M.P.H, Post-Doctoral IRTA, 301-402-9442 mizrahin@ninds.nih.gov
• Sandra Pechnik, R.N., Research Nurse, 301-435-5166 pechniks@ninds.nih.gov
• LaToya Sewell, Nurse Practitioner, 301-451-1670 sewelll@ninds.nih.gov
• Yehonatan Sharabi, M.D., Adjunct Clinical Investigator, 301-402-2052 sharabiy@ninds.nih.gov

Research Interests:

Dr. Goldstein's main research interests are in clinical neurocardiology, catecholamine systems, and scientific integrative medicine. The Clinical Neurocardiology Section carries out mainly patient-oriented research about disorders of brain regulation of the cardiovascular system. The research emphasizes diseases of the autonomic nervous system, where the sympathetic nervous system or catecholamines play important roles, such as autonomic failure syndrome and neurogenetic conditions featuring abnormal catecholamine synthesis or metabolism. The Section operates a renowned Clinical Neurochemistry Laboratory for assays of levels of catecholamines and their metabolites. Current research of the Section focuses on biomarkers and mechanisms of Parkinson disease and related disorders that involve abnormal catecholamine systems.

Clinical Protocols:

• Clinical Laboratory Evaluation of Primary Chronic Autonomic Failure  03-N-0004
• Reference Values for Plasma Catechols 06-N-0047
• L-Dihydroxyphenylserine (L-DOPS) for Norepinephrine Deficiency: Interactions with Carbidopa and Entacapone  08-N-0012
• Plasma Exchange for Autoimmune Autonomic Failure 06-N-0209

Selected Publications:

• Goldstein DS. (2006) Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine, Johns Hopkins University Press .
• Goldstein DS, Eisenhofer G, Kopin IJ. (2003) Sources and significance of plasma levels of catechols and their metabolites in humans, J Pharmacol Exp Ther 305, 800-811.
• Goldstein DS, Smith LJ (2002) The NDRF Handbook for Patients with Dysautonomias, Futura .
• Goldstein DS (2001) The Autonomic Nervous System in Health and Disease, Taylor & Francis .

All Selected Publications

Contact Information:

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      Last updated Tuesday, January 08, 2008