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Cellular, Organ & Systems Pathobiology Branch

This branch plans, develops and administers a program of research and training grants, fellowships, contracts, and cooperative agreements that address the pathobiology and/or pathophysiology of environmental diseases/dysfunctions caused or exacerbated by environmental agents/stressors, emphasizing

  • mechanism-based research at the cellular, organ and system level to elucidate toxicity(ies) as they relate to age/time and susceptibility;
  • basic, transitional, and clinical research on the site/mechanism of action leading to but not including population-based research;

Provides management of the NIEHS training, career development and SBIR/STTR programs;

Assesses and evaluates progress and effectiveness of programs;

Provides professional liaison for the scientific review of the above activities;

Maintains mission-relevant liaison and coordinates activities with federal and non-federal organizations, institutions, associations, societies and scientists.

Acting Branch Chief:

Cindy P. Lawler, Ph.D.
Circulatory Toxicology, Renal Toxicology, Immune System Toxicology
Tel (919) 316-4671

Health Science Administrators:

Jerrold Heindel, Ph.D.
Reproductive & Developmental Toxicology, Alternative Model Systems Development, Small Business Innovative Research & Small Business Technology Transfer (, Academic Research Enhancement Award
Tel (919) 541-0781

Michael Humble, Ph.D.
Skin Disease, Fellowship Program (, Obesity and the Built Environment (
Tel (919) 316-4621

Annette Kirshner, Ph.D.
Developmental and Behavioral Neurotoxicology, Musculoskeletal Toxicology, Amyotrophic Lateral Sclerosis
Tel (919) 541-0488

Cindy Lawler, Ph.D.
Neurotoxicology of Aging, Autism, Collaborative Centers for Parkinson's Disease Environmental Research (
Tel (919) 316-4671

Srikanth Nadadur, Ph.D.
Cardiovascular Health, Nanotoxicology, Pulmonary Pathobiology
Tel (919) 541-5327

Carol Shreffler, Ph.D.
Training and Career Programs (, Fellowship Programs (, Transition to Independent Positions, Liver and Digestive System Toxicology
Tel (919) 541-1445

Frederick Tyson, Ph.D.
Advanced Research Cooperation in Environmental Health, Centers for Oceans and Human Health (, Centers for Population Health and Health Disparities (, Children's Centers (, Epigenetics
Tel (919) 541-0176

Program Analyst:

Ms. Astrid Haugen
Tel (919) 541-4415

Branch Fax Number (919) 541-5064

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Last Reviewed: January 09, 2009