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Wei Li, Ph.D., Investigator

Dr. Li received his medical degree in 1997 from Zhejiang University School of Medicine in China, and his Ph.D. in Neuroscience in 2003 from the University of Texas at Houston, where he studied the organization of reciprocal feedback synapse at the axon terminal of the retinal bipolar cell in Dr. Stephen Massey's laboratory. From 2003 to 2007, as a postdoctoral fellow, he worked with Dr. Steven DeVries at Northwestern University where he investigated synaptic connections between photoreceptors and bipolar neurons in a mammalian retina. Dr. Li joined NEI as the principle investigator of the Unit of Retinal Neurophysiology in 2007. His unit uses a variety of physiological and anatomical techniques to explore retinal synapses and circuits and their functions in vision.
Photo of Wei  Li, Ph.D., Investigator

Research Interests:
Retinal neurons reconstructed from confocal images

Synaptic connections of retinal neurons

Our unit studies the structure and function of retinal synapses and circuits. Although we know the basic structure and major cell types of the retina, it remains much of a "black box" in terms of the connections and functions of these neurons. Our long-term research goal is to understand how the neuronal circuits are wired in this "black box" under normal conditions and how the circuits are altered during pathological processes. Both pieces of information will be crucial for the design of biological and/or prosthetic interventions aiming to restore vision in many types of blindness caused by retinal degenerative diseases. Some of the research topics are: 1) we will exploit a combination of anatomical, physiological, and imaging approaches to study synaptic connectivity using in vitro slice and flat-mount preparations of the ground squirrel retina. This is an excellent model system to study the cone vision, as ground squirrel is one of the rare mammals whose retina is cone-dominated and resembles the fovea of human retina. 2) We are interested in studying synaptic alteration and regeneration in the ground squirrel retina during and after hibernation - another unique feature of the ground squirrel. 3) We are going to use a combination of genetically engineered mouse lines to study the development of certain synapses and circuits in the mouse retina. More information about our unit can be found at: http://www.nei.nih.gov/intramural/retinal_neuro.asp


Contact Information:

Dr. Wei Li
7 Memorial Drive,
Building 7, Room 217
Mail Stop Code: 0703
Bethesda, MD 20892-

Telephone: (301) 496-6669 (office), (301) 496-0000 (laboratory), (301) 496-1759 (fax)
Email: liwei2@nei.nih.gov

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Last updated Monday, November 26, 2007