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| David M. Lovinger, Ph.D., Senior Investigator |
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Dr. Lovinger received a B.A. in Psychology from the University of Arizona in 1981 and a Ph.D. in Psychology from Northwestern University in 1987. At Northwestern, he worked with Dr. Aryeh Routtenberg studying the roles of Protein Kinase C and its substrate, the GAP-43/F1 protein, in hippocampal long-term potentiation. His postdoctoral research at the NIAAA focused on the effects of alcohol on ligand-gated ion channels. In 1991 Dr. Lovinger moved to the Vanderbilt University School of Medicine as an Assistant Professor, where in 1998 he rose to the rank of Professor. At Vanderbilt he was also the Deputy Director for Biomedical Science and the Director of the Neuroscience Core within the Kennedy Center. Dr. Lovinger joined the NIAAA in 2001 as a Senior Investigator and Chief of the Laboratory of Integrative Neuroscience. His laboratory is currently studying the modulation and plasticity of synaptic transmission at corticostriatal synapses and the mechanisms by which abused substances effect synaptic transmission.
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Selected Recent Publications:
Ronesi, J, Lovinger, DM (2005) Induction of striatal long-term synaptic depression by moderate frequency activation of cortical afferents in rat., Journal of Physiology 562 (Pt.1), 245-256.
Full Text/Abstract
Ronesi, J., Gerdeman, G.L., Lovinger, D.M. (2004) Disruption of endocannabinoid release and striatal long-term depression by postsynaptic blockade of endocannabinoid membrane transport., Journal of Neuroscience 24(7), 1673-1679.
Full Text/Abstract
M.I Davis, J. Ronesi, D.M. Lovinger (2003) A predominant role for inhibition of the adenylate cyclase PKA pathway in ERK activation by CB1 receptors in N1E-115 neuroblastoma cells., Journal of Biological Chemistry 278(49), 48973-48980.
Full Text/Abstract
Partridge, J. and Lovinger, D.M. (2002) Nicotinic Acetylcholine Receptors Interact with Dopamine in Induction of Striatal Long-Term Depression., J. Neurosci. 22, 2541-2549.
Gerdeman, G. and Lovinger, D.M. (2002) Postsynaptic endocannabinoid release is necessary for long-term depression in the striatum., Nature Neuroscience 5, 446-451.
Sung, K-W., Choi, S. and Lovinger, D.M. (2001) Activation of group I metabotropic glutamate receptors is necessary for induction of long-term synaptic depression at striatal synapses., J. Neurophysiol. 86, 2405-2412.
Gerdeman, G.L. and Lovinger, D.M. (2001) The CB1 cannabinoid receptor inhibits synaptic release of glutamate in rat dorsolateral striatum., J. Neurophysiol. 85, 468-471.
All Selected Publications
Contact Information:
Dr. David M. Lovinger
Clinical and Biological Research Unit
NIAAA
Building Park, Room 158H
12420 Parklawn Dr, MSC 8115
Bethesda, MD 20892-8115
Telephone: (301) 443-2445 (office),
(301) 443-2445 (laboratory),
(301) 480-1734 (fax)
Email: lovindav@mail.nih.gov
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