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| Brian M. Martin, Ph.D., Investigator |
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Dr. Martin attended the University of Waterloo, Ontario, Canada, where he obtained a B.Sc. in Applied Chemistry and a Ph.D. in Chemistry. He received post-doctoral training at the Carlsberg Laboratory in Copenhagen, Denmark and the Max Planck Institute in Dortmund, Germany. Dr. Martin originally came to the NIH in 1983 as a member of the Clinical Neuroscience Branch, but in 2002 was enlisted to head the Molecular Structure Unit of the Laboratory of Neurotoxicology, NIMH. Dr. Martin has a strong background in protein chemistry. His research is focused on protein expression in development and differentiation.
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Research Interests:
During the past decade the human genome has been mostly decoded. However, given the discovery of many genes and their annotation in databases, we still don�t know their distribution or the function of the proteins that they encode. Furthermore, we don�t understand the translational consequences of these genes nor the post-translational events that result in proteins found in different tissues, organs or biological fluids. The study of the protein component of an organism, proteomics, includes the study of protein expression changes during development or in differentiation processes in either the normal or disease state as well as protein-protein interaction. Dr. Martin studies the structure function relations of proteins/ peptides as well as the subsequent cloning and expression of cDNAs for proteins/ peptides of interest. The Unit focuses on the identification and characterization of bioactive components of biological fluids and tissues. Other projects of interest are drawn from proteins that are of medical interest due to their ability to interact with binding partners, their allergic properties or their resulting modification/ alteration by compounds normally prescribed in a medical setting or their propensity to cause or alter disease states. The group makes use of mass spectral techniques such as SELDI, MALDI and MS/MS to study, define and interpret the changes in protein expression and structure in biological systems.
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Selected Recent Publications:
Mannes AJ, Martin BM, Yang HY, Keller JM, Lewin S, Gaiser RR, Iadarola MJ. (2003) Cystatin C as a cerebrospinal fluid biomarker for pain in humans, Pain 102, 251-256.
Mandrich L, Caputo E, Martin BM, Rossi M, Manco G (2002) The Aes protein and the monomeric alpha-galactosidase from Escherichia coli form a non-covalent complex. Implications for the regulation of carbohydrate metabolism, J BIol Chem 277, 48241-48247.
Kim ad, Baker AS, Dunaway-Mariano D, Metcalf WW, Wanner BL, Martin BM (2002) The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway, J Bacteriol 184, 4134-4140.
Mercante F, Altamentova SM, Mickle DA, Weisel RD, Thatcher BJ, Martin BM, Marshall JG, Cowan DB, Li RK (2002) The characterization and purification of a human transcription factor modulating the glutathione peroxidase gene in response to oxygen tension , Mol Cell Biochem 229, 73-83.
Contact Information:
Dr. Brian M. Martin
Molecular Structure Unit
Laboratory of Neurotoxicology, NIMH
Building 10, Room 3N309
10 Center Drive, MSC 1262
Bethesda, MD 20892-1262
Telephone: (301) 496-7787 (office),
(301) 496-7787 (laboratory),
(301) 480-0198 (fax)
Email: martinb@irp.nimh.nih.gov
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