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| Howard Alan Fine, M.D., Senior Investigator |
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Dr. Fine received his B.A. from the University of Pennsylvania and his M.D. from Mount Sinai School of Medicine, New York. After medical internship and residency at the University of Pennsylvania, he completed a fellowship in medical oncology at the Harvard Medical School's Dana-Farber Cancer Institute in Boston, MA. Dr. Fine received the NCI Director's Gold Star Award in 2004, the Dana-Farber Harvard Cancer Center's Clinical Investigator Award in 1999 and the Emil Frei III Clinical Investigator Award in 1993. As a former director of both the Neuro-Oncology Disease Center at the Dana-Farber Cancer Institute and the Neuro-Oncology Program at the Harvard Cancer Center, he joined the NCI's Center for Cancer Research in 2000 to help establish its Neuro-Oncology Branch. As chief of the Neuro-Oncology Branch, Dr. Fine's lab focuses on angiogenesis, glioma molecular genetics, and neural stem cell biology.
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Selected Recent Publications:
Purow BW, Haque RM, Noel MW, Qin S, Burdick MJ, Jeongwu L, Dragan M, Tilak S, Pastorino S, Mikolaenko I, Eberhart CG, Fine HA (InPress) Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation, Cancer Research.
Fine HA. (InPress) Targeted therapies for malignant gliomas, Nature Review Drug Discovery, .
Anderson SA, Glod J, Arbab As, Noel N. Asharia P, Fine HA, Frank JA. (2005) . Non-invasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model. , Blood 105, 420-425.
Chen W, Lee J, Cho S. Fine HA. (2004) . Proteosome-mediated destruction of the cyclin A/cyclin-dependent kinase 2 complex suppresses tumor cell growth in vitro and in vivo. , Cancer Research 64(11), 3949-57.
Hui AM, Zhang W, Chen W, Xi D, Purow B, Friedman GC, Fine HA. (2004) Agents with selective estrogen receptor modulator activity induce apoptosis in vitro and in vivo in estrogen receptor-negative glioma cells., Cancer Research 64, 9115-9123.
Sun L, Lee J, Fine HA. (2004) Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury, J Clin Invest . 113(9), 1364-1374.
Fine HA, Wen PY, Maher EA, Viscosi E, Batchelor T, Lakhani N, Figg WD, Purow BW, Borkowf CB. (2003) . A phase II trial of Thalidomide and BCNU for patients with recurrent high grade gliomas., J. Clin Oncol 21(12), 2299-304.
All Selected Publications
Contact Information:
Dr. Howard Alan Fine
Neuro-Oncology Branch, NCI
Bloch Building #82, Room 235
9030 Old Georgetown Road, MSC 8200
Bethesda, MD 20892-8200
Telephone: (301) 402-6383 (office),
(301) 480-2246 (fax)
Email: hfine@mail.nih.gov
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