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| Robert B. Innis, M.D., Senior Investigator |
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Dr. Innis received his B.S. degree from Yale University in 1974 and an M.D. from Johns Hopkins in 1978. He obtained a Ph.D. degree in neuropharmacology from Johns Hopkins in 1981 under the mentorship of Solomon Snyder. After completing a residency in psychiatry at Yale University in 1984, he joined their faculty in the Departments of Psychiatry and Pharmacology. Dr. Innis left Yale in 2001 to become Chief of a new laboratory at NIMH with an emphasis on brain imaging using PET (positron emission tomography). Expanded state-of-the-art facilities for both radiochemistry and PET imaging at NIH provide unique opportunities for the application of this radiotracer method to patients with neuropsychiatric disorders. The overall goals of Dr. Innis's laboratory are to develop new radiotracers that image molecular targets in the brain, to evaluate these tracers in animals and healthy human subjects, and then to extend their use to patients with neuropsychiatric disorders.
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Staff:
- Kohji Abe, Ph.D., Visiting Scientist, (301) 451-5014 abek@mail.nih.gov
- Elizabeth C Alzona, A.A., Administrative Branch Manager, (301) 594-1089 alzonae@irp.nimh.nih.gov
- Amira Brown, Ph.D., Postdoctoral Fellow, (301) 435-1695 amirabrown@mail.nih.gov
- Amanda Farris, B.S., Postbaccalaureate IRTA, (301) 594-1381 farrisa@mail.nih.gov
- Maria D Ferraris Araneta, C-RNP, Nurse, (301) 496-9423 ferrarism@mail.nih.gov
- Yota Fujimura, M.D., Ph.D., Postdoctoral Fellow, (301) 594-5661 fujimuray@mail.nih.gov
- Masahiro Fujita, M.D., Ph.D., Staff Scientist, (301) 451-8898 fujitam@mail.nih.gov
- Robert Gladding, CNMT, Research PET Technologist, (301) 594-1432 gladdingr@mail.nih.gov
- Pavitra Kannan, Postbaccalaureate IRTA, (301) 594-5721 kannanp@mail.nih.gov
- William C. Kreisl, M.D., Clinical Fellow, (301) 451-8894 kreislw@mail.nih.gov
- Jeih-San Liow, Ph.D., Staff Scientist, (301) 451-8862 LiowJ@intra.nimh.nih.gov
- Nicholas Seneca, M.S., Postdoctoral Fellow, (301) 451-8895 SenecaN@intra.nimh.nih.gov
- Garth Terry, Predoctoral Fellow, (301) 594-1371 gartht@mail.nih.gov
- Ed Tuan, Postbaccalaureate IRTA, (301) 594-1370 tuane@mail.nih.gov
- Sami Zoghbi, Ph.D., Staff Scientist, (301) 435-7911 zoghbis@mail.nih.gov
Research Interests:
My laboratory develops and uses PET (positron emission tomography) tracers as molecular probes of physiology and pathophysiology in animals and humans. In addition to traditional receptor targets, we use radiolabeled probes for in vivo imaging of intracellular signal transduction (e.g., cAMP phosphodiesterase), gene expression (e.g., dopamine transporters expressed on transplanted embryonic stem cells), and a mitochondrial protein that is a marker for inflammatory cells (activated microglia and macrophages). This Section includes multidisciplinary expertise in pharmacology, animal experimentation, clinical neuroscience, digital image analysis, and human evaluation of investigational radiopharmaceuticals.
Imaging is performed in primates and rodents to assess the utility of new probes and to explore models of human pathophysiology. For example, we imaged the serotonin transporter in adult monkeys with a history maternal deprivation to explore the role of serotonin in the abnormal behaviors of these animals. In vivo imaging of rodents has allowed us to study valuable genetically-modified animals - e.g., mice that over express amyloid or those lacking an important drug efflux transporter (P-glycoprotein) at the blood brain barrier.
Approximately half of our PET scans are performed in humans, with several studies that are the "first-in-human" use of novel PET radioligands - e.g., a new probe for amyloid, the cannabinoid CB1 receptor, a probe for cellular inflammation. We have several on-going or soon-to-be-started studies including imaging of the substance P (NK1) receptor in patients with panic disorder; imaging of neuroinflammation in patients with multiple sclerosis, and AIDS dementia; and measurement of the cAMP system in patients with depression, before and after antidepressant treatment.
See the following web site for the most up-to-date information on Dr. Innis's laboratory, including recent findings, representative publications in pdf format, and current studies.
http://intramural.nimh.nih.gov/mood/proginfo/mib/neuro.htm
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Selected Recent Publications:
F. Yasuno, A.K. Brown, S.S. Zoghbi, J.H. Krushinski, E. Chernet, J. Tauscher, J. Schaus, L. Phebus, R.L. A.K. Chesterfield, C. Felder, Gladding, J. Hong, C. Halldin, V.W. Pike, and R.B. Innis (InPress) The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain, Neuropsychopharmacology.
Y.H. Ryu, J.-S. Liow, S.S. Zoghbi, M. Fujita, J. Collins, D. Tipre, J. Sangare, J. Hong, V.W. Pike, and R.B. Innis (2007) Disulfiram inhibits defluorination of [18F]FCWAY, reduces bone radioactivity, and enhances visualization of radioligand binding to 5-HT1A receptors in brain, J. Nucl. Med. 48, 1154-1161.
M. Imaizumi, E. Briard, S.S. Zoghbi, J. Hong, J.L. Musachio, R. Gladding, V.W. Pike, R.B. Innis, and M. Fujita (2007) Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain, Synapse 61, 595-605.
M. Fujita, M. Imaizumi, C. D'Sa, S.S. Zoghbi, M.S. Crescenzo, J. Hong, J.L. Musachio, A.D. Gee, J. Seidel, M.V. Green, V.W. Pike, R.S. Duman, and R.B. Innis (2007) In vivo and in vitro measurement of brain phosphodiesterase 4 in rats after antidepressant treatment, Synapse 61, 78-86.
M. Imaizumi, H.-J. Kim, S.S. Zoghbi, E. Briard, J. Hong, J.L. Musachio, C. Ruetzler, D.-M. Chuang, V.W. Pike, R.B. Innis, and M. Fujita (2007) PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat , Neurosci. Lett. 411, 200-205.
J.A. Rodriguez-Gomez, J.-Q. Lu, I. Velasco, S. Rivera, S.S. Zoghbi, J-S. Liow, J.L. Musachio, J. Shah, F.T. Chin, M.S. Crescenzo, H. Toyama, J. Seidel, M.V. Green, P.K. Thanos, M. Ichise, V.W. Pike, R.B. Innis and R.M. McKay (2007) Functional characterization of embryonic stem cell-derived dopamine neurons in a rodent model of Parkinson disease, Stem Cells 25, 918-928.
All Selected Publications
Contact Information:
Dr. Robert B. Innis
Molecular Imaging Branch, NIMH
PET Neuroimaging Sciences Section
Building 31, Room B2-B37
31 Center Drive MSC 2035
Bethesda, MD 20895-2035
Telephone: (301) 594-1368 (office),
(301) 594-1089 (laboratory),
(301) 480-3610 (fax)
Email: robert.innis@nih.gov
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