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| Joel E. Kleinman, M.D., Ph.D., Senior Investigator |
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Dr. Kleinman received his B.S., M.D. and Ph.D. degrees from the University of Chicago in 1966, 1973 and 1974, respectively. His graduate studies with A. Heller and P. Hoffmann involved the effects of monoamines on carbohydrate metabolism in the rat brain. Dr. Kleinman did an internship at San Francisco General Hospital and residencies in psychiatry and neurology at Massachusetts Mental Health Center and George Washington University, respectively. He joined the NIMH as a Fellow in 1976, became a Section Chief in 1984, and has done research on schizophrenia for 25 years with an emphasis on postmortem studies. He is a past President of the Society of Biological Psychiatry and a recipient of the A. E. Bennett Award and an Outstanding Service Medal from the U.S.P.H.S. His laboratory explores the neuropathology of schizophrenia.
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Selected Recent Publications:
Weickert CS, Miranda-Angulo AL, Wong J, Perlman WR, Ward SE, Radhakrisnma V, Straub RE, Weinberger DR and Kleinman JE (2008) Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia., Human Molecular Genetics 17, 2293-2309.
Full Text/Abstract
Meyer-Lindenberg A, Straub RE, Lipska BK, Verchinski BA, Goldberg TE, Callicott JH, Egan MF, Huffaker SS, Mattay VS, Kolachana BS, Kleinman JE and Weinberger DR (2007) Genetic evidence implicating DARPP-32 in human fronto-striatal structure, function and cognition., J Clin Investigation 117, 672-682.
Lipska BK, Peters T, Hyde TM, Halim N, Horowitz C, Mitkus S, Weickert CS, Matsumoto M, Sawa A, Straub R, Vakkalanka R, Herman MM, Weinberger DR and Kleinman JE (2006) Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs., Human Molecular Genetics 15, 1245-1258.
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Law AJ, Lipska BK, Weickert CS, Hyde TM, Straub RE, Hashimoto R, Harrison PJ, Kleinman JE and Weinberger DR (2006) Neuregulin 1 (NRG1) transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease., Proc. Natl. Acad. Sci. USA 103, 6747-6752.
Full Text/Abstract
Weickert CS, Straub RE, McClintock BW, Matsumoto M, Hashimoto R, Hyde TM, Herman MM, Weinberger DR and Kleinman JE (2004) Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain., Archives of General Psychiatry 61, 544-555.
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Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM, Herman MM, Apud J, Egan MF, Kleinman JE and Weinberger DR (2004) Functional analysis of genetic variation in COMT: Effects on mRNA, protein and enzyme activity in postmortem human brain., Am. J. Human Genetics 75, 807- 821.
Full Text/Abstract
Akil M, Kolachana BS, Rothmond DA, Hyde TM, Weinberger DR and Kleinman JE (2003) COMT genotype and dopamine regulation in the human brain., J. of Neuroscience 23, 2008-2013.
Full Text/Abstract
All Selected Publications
Contact Information:
Dr. Joel E. Kleinman
Neuropathology Section
Clinical Brain Disorders Branch, NIMH
Building 10, Room 4S237A
10 Center Drive, MCS 1379
Bethesda, MD 20892-1379
Telephone: (301) 402-7908 (office),
Email: KleinmaJ@INTRA.NIMH.nih.gov
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