Metastatic disease is cancer that has spread from the place in which it started to other parts of the body. When the cancer has spread to the lungs, the prognosis is better if the cancer is in only one lung and in fewer places in the lung. For cancer that has spread to the bone, prognosis is better if the tumors are all in the same bone.

Osteosarcoma

Treatment of osteosarcoma with metastasis may be one of the following:

• Chemotherapy followed by surgery to remove the cancer followed by adjuvant chemotherapy.



• Surgery to remove the cancer followed by adjuvant chemotherapy.



• A clinical trial of chemotherapy with or without biologic therapy.

Surgery often includes removal of cancer that has spread to the lungs.

Malignant fibrous histiocytoma of bone

Treatment of malignant fibrous histiocytoma of bone with metastasis is the same as for osteosarcoma with metastasis.

Multifocal osteosarcoma

Treatment of multifocal osteosarcoma includes chemotherapy and surgery.

Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with metastatic osteosarcoma and metastatic childhood malignant fibrous histiocytoma of bone. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

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