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NTP BSC Technical Reports Review - October 30, 1998
[Federal Register: September 30, 1998 (Volume 63, Number 189)]
[Notices]
[Page Page 52282-52283]
Public Health Service
National Toxicology Program
National Toxicology Program (NTP) Board of Scientific Counselors' Meeting; Review of Draft NTP Technical Reports
Pursuant to Public Law 92-463, notice is hereby given of the next meeting of the NTP Board of Scientific Counselors' Technical Reports Review Subcommittee on October 30, 1998, in the Conference Center, Building 101, South Campus, National Institute of Environmental Health Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park, North Carolina. The meeting will begin at 9:00 a.m. on October 30, and is open to the public. The agenda topic is the peer review of draft Technical Reports of long-term toxicology and carcinogenesis studies from the National Toxicology Program.
Tentatively scheduled to be peer reviewed on October 30 are draft Technical Reports of five two-year studies, listed alphabetically, along with supporting information in the attached table. The draft Report on triethanolamine had been peer reviewed previously but is being returned for rereview as this was the first study in which infection of B6C3F1 mice with Helicobacter hepaticus was discovered. All studies were done using Fischer 344 rats and B6C3F1 mice. The order of review is given in the far right column of the table. By September 30, 1998, full copies of these draft reports will be available for free on the Internet for public review and comment through the Environmental Health Information Service (EHIS) at http://ehis.niehs.nih.gov. Printed copies can be obtained, as available, from: Central Data Management, MD E1-02, P.O. Box 12233, Research Triangle Park, NC 27709 (919/541-3419), FAX (919/541-3687), email: CDM@niehs.nih.gov.
Public comment on any of the Technical Reports is welcome. Persons wanting to make a formal presentation regarding a particular Technical Report must notify the Executive Secretary by telephone at 919/541-3971, by FAX at 919/5410295, by mail, or by email at hart@niehs.nih.gov, by no later than October 27, 1998, and, if possible, provide a written copy in advance of the meeting so copies can be made and distributed to all Subcommittee members and staff, and made available at the meeting for attendees. Written statements could supplement and may expand on the oral presentation. Oral presentations should be limited to no more than five minutes.
The Program would welcome receiving toxicology and carcinogenesis information from completed, ongoing, or planned studies by others, as well as current production data, human exposure information, and use patterns for any of the chemicals listed in this announcement. Please contact Central Data Management at the address given above, and they will relay the information to the appropriate staff scientist.
The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233, Research Triangle Park, North Carolina 27709 will furnish agenda and a roster of Subcommittee members prior to the meeting. Summary minutes subsequent to the meeting will be available upon request to Central Data Management.
Dated: September 21, 1998
__________________________
Kenneth Olden, Ph.D.
Director
National Toxicology Program
for Review at the Meeting of the NTP Board of Scientific Counselor's
Technical Reports Review Subcommittee
October 30, 1998
Chemical CAS Number | Technical Report Number | Primary Uses | Route/ Exposure Levels | Review Order |
Ethylene Glycol Monobutyl Ether 111-76-2 | TR-484 | Solvent for mineral oils, in spray lacquers, varnish removers, metal cleaners | Inhalation (air): Rats: 0, 31, 62.5, or 125 ppm; Mice: 0, 62.5, 125, or 250 ppm (50/sex/species/group) | |
Glutaraldehyde 111-30-8 | TR-490 | Disinfectant and sterilizing agent; Embalming fluid; chemical intermediate for adhesives, electrical products, tanning soft leathers; in photographic developing, dental materials. | Inhalation (air): Rats: 0, 250, 500, or 750 ppm; Mice: 0, 62.5, 125, or 250 ppb (50/sex/species/group) | |
Methyleugenol 93-15-2 | TR-491 | Insect attractant; major constituent of clove oil, used extensively in perfumes & flavorings | Gavage (methylcellulose): Rats & Mice: 0, 37, 75, or 150 mg/kg (50/sex/species/group) | |
Oxymetholone 434-07-1 | TR-485 | Maintain a positive nitrogen balance; to promote weight gain in Cachexia, debilitating diseases, serious infections, burns, trauma and surgery; treatment of anemias. | Gavage (methylcellulose): Rats only: Males: 0, 3, 30, or 150 mg/kg; Females: 0, 3, 30, or 100 mg/kg | |
Triethanolamine 102-71-6 (Reconsideration and discussion of Helicobacter issue) | TR-449 | Intermediate in the manufacture of surfactants, textile specialties, waxes, polishes, herbicides, petroleum demulsifiers, toilet goods, cement additives, cutting oils, in making mineral & vegetable oil emulsions, solvent, pharmaceutic aid (alkalizer) | Topical (acetone): Male Rats: 0, 32, 63, or 125 mg/kg; Female Rats: 0, 63, 125, or 250 mg/kg; Male Mice: 0, 200, 630, or 2000 mg/kg; Female Mice: 0, 100, 300, or 1000 mg/kg (60/group) |
By September 30, 1998, full copies of these draft reports will
be available for free on the Internet for public review and comment
through the Environmental Health Information Service (EHIS) at
http://ehis.niehs.nih.gov. Printed copies can be obtained by contacting
Central Data Management by phone at 919-541-3418; fax: 919-541-3687;
or email: CDM@niehs.nih.gov.
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