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Home » About the NTP » Federal Register Notices » TCDD Re-review - call for comments
National Toxicology Program; Call for Public Comments; Agents, Substances, Mixtures and Exposure Circumstances Proposed for Listing in or Removing from the Report on Carcinogens, Ninth Edition
The National Toxicology Program (NTP) announces its intent to re-review 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CAS # 1746-01-6) for possible listing in the Report on Carcinogens, Ninth Edition as Known To Be A Human Carcinogen..
Background
This Report is a Congressionally-mandated listing of Known
Human Carcinogens and Reasonably Anticipated Human Carcinogens
and its preparation is delegated to the National Toxicology Program
by the Secretary, Department of Health and Human Services (HHS).
Section 301 (b) (4) of the Public Health Service Act, as amended,
provides that the Secretary, (HHS), shall publish a report which
contains a list of all substances (1) which either are known to
be human carcinogens or may reasonably be anticipated to be human
carcinogens; and (2) to which a significant number of persons
residing in the United States (US) are exposed. The law also states
that the reports should provide available information on the nature
of exposures, the estimated number of persons exposed and the
extent to which the implementation of Federal regulations decreases
the risk to public health from exposure to these chemicals.
2,3,7,8- Tetrachlorodibenzo-p-dioxin (TCDD) was reviewed in public session by the NTP Board of Scientific Counselors Subcommittee for the Report on Carcinogens on October 30 & 31, 1997. This review resulted in the Subcommittee's recommendation to upgrade the TCDD listing from Reasonably Anticipated to Be A Human Carcinogen to Known To Be A Human Carcinogen.
NTP announces a re-review of 2,3,7,8-tetrachlorodibenzo-p-dioxin
and requests public comments
Following his review of the proceedings of that meeting, the
NTP Director has determined that the October 30 & 31 public
review of TCDD may not have been adequate and has directed that
the nomination of TCDD for upgrading to a Known to be Human
Carcinogen in the Report on Carcinogens be formally reviewed
again by the NTP Board of Scientific Counselors Subcommittee for
the Report on Carcinogens in December 1998. The TCDD background
document provided to the NTP Board Subcommittee and the public
comments and the summary minutes of the October 30 & 31 1997,
review by the NTP Board Subcommittee are available upon request.
The NTP wants to insure that all relevant information for TCDD
pertaining to its epidemiology and the mechanism of tumor formation
in humans and laboratory animals is adequately considered and
solicits additional relevant information in support of or against
the nomination to list TCDD as a Known to be Human Carcinogen
in the Report on Carcinogens, Ninth Edition. In light of the decision
to re-review TCDD, the deadline for public comments on dioxin
will be extended until June 15, 1998 (see Federal Register: March
19, 1998 (Volume 63, Number 53, Page 13418). All comments received
will be considered in the preparation of any additional information
to supplement the original background document. Any new or supplementary
information to be provided to the NTP Board Subcommittee members
will be available to the public approximately one month prior
to the December peer review meeting.
Requests for the background information described, comments, or questions should be directed to Dr. C. W. Jameson, National Toxicology Program, Report on Carcinogens, 79 Alexander Drive, Building 4401, P.O. Box 12233, Research Triangle Park, NC 27709; phone: (919) 541-4096, fax: (919) 541-2242, email: jameson@niehs.nih.gov.
Dated: April 8, 1998
____________________________
Kenneth Olden, Ph. D.
Director
National Toxicology Program
[Billing Code 4140-01-P]
Web page last updated on June 21, 2005
The National Institute of Environmental Health Sciences is one of the National Institutes of Health within the U.S. Department of Health and Human Services. The National Toxicology Program is headquartered on the NIEHS campus in Research Triangle Park, NC.