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tretinoin A naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of tretinoin has teratogenic and embryotoxic properties. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms: | | all-trans retinoic acid all-trans vitamin A acid beta-retinoic acid retinoic acid TRA trans retinoic acid trans vitamin A acid tretinoinum Vitamin A Acid | | | US brand names: | | Aberel Aknoten Avita Renova Retin-A Retin-A MICRO Vesanoid | | | Foreign brand names: | | Airol Cordes Vas Dermairol Epi-Aberel Eudyna Retisol-A Stieva-A Stieva-A Forte Vitinoin | | | Abbreviation: | | ATRA | | | Code name: | | Ro 5488 | | | Chemical structure name: | | (All-E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid | | |
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