Tetramethyl succinonitrile

IDLH Documentation

CAS number: 3333­52­6

NIOSH REL: 3 mg/m3 (0.5 ppm) TWA [skin]

Current OSHA PEL: 3 mg/m3 (0.5 ppm) TWA [skin]

1989 OSHA PEL: Same as current PEL

1993­1994 ACGIH TLV: 2.8 mg/m3 (0.5 ppm) TWA [skin]

Description of substance: Colorless, odorless solid.

LEL: . Unknown

Original (SCP) IDLH: 5 ppm

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1972] that 6 ppm for 30 hours was lethal to rats [Spolyar 1948]. A concentration of 22 ppm is obviously too high to be chosen as the IDLH, because no mice survived a 3.5­hour exposure at this concentration [Hecht and Kimmerle 1956­1957 as quoted by Reinl 1957].

Short­term exposure guidelines: None developed

ACUTE TOXICITY DATA:

Lethal concentration data:

Species
Reference
LC50

(ppm)
LCLo

(ppm)
Time
Adjusted 0.5-hr

LC (CF)
Derived value
MouseHecht &Kimmerle 1956/1957
-----
28
3 hr
50 ppm (1.8)
5.0 ppm
MouseHecht &Kimmerle 1956/1957
LC100: 22
-----
3.5 hr
42 ppm (1.9)
4.2 ppm
RatSpolyar 1948
-----
6
30 hr
24 ppm (3.91)
2.4 ppm

Lethal dose data:

Species
Reference
Route
LD50

(mg/kg)
LDLo

(mg/kg)
Adjusted LD
Derived value
RatJohannsen &ivinskas 1986
oral
38.9
-----
48 ppm
4.8 ppm

Human data: None relevant for use in determining the revised IDLH.



Revised IDLH: 5 ppm [Unchanged]

Basis for revised IDLH: Based on acute inhalation toxicity data in animals [Hecht and Kimmerle 1956­1957], the original IDLH for tetramethyl succinonitrile (5 ppm) is not being revised at this time.

REFERENCES:

1. ACGIH [1972]. Tetramethyl succinonitrile. In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 254.

2. Harger RN, Hupieu HR [1949]. Toxicity of tetramethyl succinonitrile and the antidotal effects of thiosulphate, nitrile, and barbiturates. Fed Proc 8:205.

3. Hecht G, Kimmerle H [1956/1957]. Toxikologische Untersuchungen uber Tetramethyl-bernsteinsauredinitril. Unpublished investigations (in German). [From Reinl W [1957]. Intoxication in manufacturing of plastics by tetramethyl­succinic acid dinitrile. Arch Toxikol 16:367­380 (in German).]

4. Johannsen FR, Livinskas GJ [1986]. Subchronic toxicity of tetramethyl succinonitrile. Fundam Appl Toxicol 7:41­48.

5. Reinl W [1957]. Intoxication in manufacturing of plastics by tetramethyl­succinic acid dinitrile. Arch Toxikol 16:367­380 (in German).

6. Spolyar LW [1948]. Indiana chemists report toxicity of product of Porofor M. Ind Hyg Newsletter 8(10)3.

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