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HLA-A1, A2, B35-restricted survivin peptides/Montanide ISA-51 vaccine A peptide vaccine comprised of synthetic HLA-A1, -A2 and -B35 restricted survivin epitopes combined with the adjuvant Montanide ISA-51 with potential antineoplastic activity. Upon administration, HLA-A1, A2, B35-restricted survivin peptides/Montanide ISA-51 vaccine may stimulate a cytotoxic T cell response against tumor cells that overexpress survivin, resulting in tumor cell lysis. Montanide ISA-51, also known as incomplete Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant that non-specifically stimulates cell-mediated immune responses to antigens. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090115082435im_/http://www.cancer.gov/images/spacer.gif) | survivin peptide vaccine | | ![](https://webarchive.library.unt.edu/eot2008/20090115082435im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090115082435im_/http://www.cancer.gov/images/spacer.gif) | SRV PEP VAC | | ![](https://webarchive.library.unt.edu/eot2008/20090115082435im_/http://www.cancer.gov/images/spacer.gif) |
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