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hydroxyurea
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Synonyms: | | HYD
Hydroxycarbamide
Hydurea | | | | US brand names: | | Droxia
Hydrea | | | | Foreign brand names: | | Litalir
Onco-Carbide
Oxeron
Syrea | | | | Abbreviation: | | HU | | | | Code names: | | SQ-1089
WR 83799 | | |
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