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1.		A Study of Systemic Hedgehog Antagonist With Concurrent Chemotherapy and Bevacizumab As First-Line Therapy for Metastatic Colorectal Cancer

	Phase				Type				Status				Age				Sponsor				Protocol IDs

	Phase II				Treatment				Active				18 and over				Pharmaceutical / Industry				SHH4429g NCT00636610


2.		A Study of GDC-0449 As Maintenance Therapy in Patients With Ovarian Cancer in a Second or Third Complete Remission

	Phase				Type				Status				Age				Sponsor				Protocol IDs

	Phase II				Treatment				Active				18 and over				Pharmaceutical / Industry				SHH4489g NCT00739661

Last Modified: 10/9/2008 First Published: 1/30/2008


3.		Phase I Study of Systemic Hedgehog Antagonist GDC-0449 in Patients With Locally Advanced or Metastatic Solid Tumors

	Phase				Type				Status				Age				Sponsor				Protocol IDs

	Phase I				Biomarker/Laboratory analysis, Treatment				Active				18 and over				NCI, Pharmaceutical / Industry				JHOC-J06131 J06131, GENETECH-SHH3925g, NCT00607724

First Published: 1/12/2009


4.		Phase I Study of Hedgehog Antagonist GDC-0449 in Pediatric Patients With Recurrent or Refractory Medulloblastoma

	Phase				Type				Status				Age				Sponsor				Protocol IDs

	Phase I				Biomarker/Laboratory analysis, Treatment				Approved-not yet active				3 to 21				NCI				PBTC-025 PBTC-025

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