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atrasentan hydrochloride The orally available hydrochloride salt of pyrrolidine-3-carboxylic acid with potential antineoplastic activity. As a selective antagonist of the endothelin-A (ETA) receptor, atrasentan binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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US brand name: | ![](https://webarchive.library.unt.edu/eot2008/20090115074523im_/http://www.cancer.gov/images/spacer.gif) | Xinlay | | ![](https://webarchive.library.unt.edu/eot2008/20090115074523im_/http://www.cancer.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/eot2008/20090115074523im_/http://www.cancer.gov/images/spacer.gif) | (+)-A 127722 ABT-627 | | ![](https://webarchive.library.unt.edu/eot2008/20090115074523im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/eot2008/20090115074523im_/http://www.cancer.gov/images/spacer.gif) | (2R,3R,4S)-4-(1,3-benzodioxo-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic Acid | | ![](https://webarchive.library.unt.edu/eot2008/20090115074523im_/http://www.cancer.gov/images/spacer.gif) |
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