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aziridinylbenzoquinone RH1 A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Code name: | | RH1 | | | Chemical structure name: | | 2,5-diaziridinyl-3-hydroxymethyl-6-methyl-1,4-benzoquinone | | |
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