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NIH Director’s Pioneer Award

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Pioneer Award Publications

Collected from Pioneer Award Recipients’ Progress Reports

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2004 PIONEER AWARD RECIPIENTS

Larry Abbott

  1. Fusi S, Drew P, Abbott LF. Cascade models of synaptically stored memories. Neuron 2005 45:599-611.
  2. Vogels TP, Abbott LF. Signal propagation and logic gating in networks of integrate-and-fire neurons. J Neurosci 2005 25:10786-95.
  3. Vogels TP, Rajan K, Abbott, LF. Neural network dynamics. Annu Rev Neurosci 2005 28:357-76.
  4. Drew PJ, Abbott LF. Extending the effects of spike-timing-dependent plasticity to behavioral timescales. Proc Natl Acad Sci U S A2006 103:8876-81. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16731625
  5. Drew PJ, Abbott LF. Models and properties of power-law adaptation in neural systems. J Neurophysiol 2006 doi:10.1152/jn.00134.2006.
  6. Rajan K, Abbott LF. Eigenvalue spectra of random matrices for neural networks. Phys Rev Lett2006 97:188104.
  7. Swinehart CD, Abbott LF. Dimensional reduction for reward-based learning. Network 2006 17:235-52.
  8. Abbott LF, Luo SX. A step toward optimal coding in olfaction. Nat Neurosci 2007;10:1342-3.
  9. Abbott LF, Rohrkemper R. A simple growth model constructs critical avalanche networks. Prog Brain Res 2007;165:13-9.
  10. Brozovic M, Abbott LF, Andersen RA. Mechanism of gain modulation at single neuron and network levels. J Comput Neurosci 2008;25:158-68.
  11. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 2008;4:313-21.
  12. Fusi S, Abbott LF. Limits on the memory storage capacity of bounded synapses. Nat Neurosci 2007;10:485-93.
  13. Mainen Z, Abbott LF. Dendrites. In: Functional Plasticity at Dendritic Synapses. Oxford: Oxford University Press; 2007.
  14. Monaco JD, Abbott LF, Kahana MJ. Lexico-semantic structure and the word-frequency effect in recognition memory. Learn Mem 2007;14:204-13. http://learnmem.cshlp.org/cgi/content/full/14/3/204
  15. Parga N, Abbott LF. Network Model of Spontaneous Activity Exhibiting Synchronous Transitions Between Up and Down States. Frontiers in Neuroscience 2007;1:57-66.
  16. Rajan K, Abbott LF. Temperature-compensated chemical reactions. Phys Rev E Stat Nonlin Soft Matter Phys 2007;75:022902.
  17. Vogels TP, Abbott LF. Gating deficits in model networks: a path to schizophrenia? Pharmacopsychiatry 2007;40 Suppl 1:S73-7.

George Q. Daley

  1. Wang, Y., F. Yates, et al. (2005). "Embryonic stem cell-derived hematopoietic stem cells." Proc Natl Acad Sci U S A 102(52): 19081-6. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16357205
  2. Weisberg, E., P. W. Manley, et al. (2005). "Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl." Cancer Cell 7(2): 129-41.
  3. Zaehres, H., M. W. Lensch, et al. (2005). "High-efficiency RNA interference in human embryonic stem cells." Stem Cells 23(3): 299-305.
  4. Azam, M., V. Nardi, et al. (2006). "Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance." Proc Natl Acad Sci U S A 103(24): 9244-9. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16754879
  5. Lensch, M. W. and G. Q. Daley (2006). "Scientific and clinical opportunities for modeling blood disorders with embryonic stem cells." Blood 107(7): 2605-12. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16332966
  6. Zaehres, H. and G. Q. Daley (2006). "Transgene expression and RNA interference in embryonic stem cells." Methods Enzymol 420: 49-64.
  7. Kim, K., P. Lerou, et al. (2007). "Histocompatible embryonic stem cells by parthenogenesis." Science 315(5811): 482-6.
  8. Nardi, V., T. Raz, et al. (2007). "Quantitative monitoring by polymerase colony assay of known mutations resistant to ABL kinase inhibitors." Oncogene.
  9. North, T. E., W. Goessling, et al. (2007). "Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis." Nature 447(7147): 1007-11.
  10. Raz, T., V. Nardi, et al. (2007). "Farnesyl transferase inhibitor resistance probed by target mutagenesis." Blood.
  11. Chan EM, Yates F, Boyer LF, Schlaeger TM, Daley GQ. Enhanced plating efficiency of trypsin-adapted human embryonic stem cells is reversible and independent of trisomy 12/17. Cloning Stem Cells 2008;10:107-18.
  12. Lu CW, Yabuuchi A, Chen L, Viswanathan S, Kim K, Daley GQ. Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos. Nat Genet 2008;40:921-6.
  13. Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, Daley GQ. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008;451:141-6.
  14. Viswanathan SR, Daley GQ, Gregory RI. Selective blockade of microRNA processing by Lin28. Science 2008;320:97-100.

Homme W. Hellinga

  1. Cuneo MJ, Changela A, Warren JJ, Beese LS, Hellinga HW. The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites. J Mol Biol 2006 362:259-70.
  2. de Lorimier RM, Tian Y, Hellinga HW. Binding and signaling of surface-immobilized reagentless fluorescent biosensors derived from periplasmic binding proteins. Protein Sci 2006 15:1936-44.
  3. Rizk SS, Cuneo MJ, Hellinga HW. Identification of cognate ligands for the Escherichia coli phnD protein product and engineering of a reagentless fluorescent biosensor for phosphonates. Protein Sci 2006 15:1745-51
  4. Allert M, Dwyer MA, Hellinga HW. Local encoding of computationally designed enzyme activity. J Mol Biol 2007 366:945-53. This paper was retracted (PDF, 1 page) on May 2, 2008.
  5. Cox JC, Lape J, Sayed MA, Hellinga HW. Protein fabrication automation. Protein Sci 2007 16:379-90. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17242375
  6. Cuneo MJ, Tian Y, Allert M, Hellinga HW. The backbone structure of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein is essentially identical to its mesophilic E. coli homolog. BMC Struct Biol 2008;8:20. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18373848
  7. Tian Y, Cuneo MJ, Changela A, Hocker B, Beese LS, Hellinga HW. Structure-based design of robust glucose biosensors using a Thermotoga maritima periplasmic glucose-binding protein. Protein Sci 2007;16:2240-50.

Joseph (Mike) McCune

  1. Emu B, Sinclair E, Favre D, Moretto WJ, Hsue P, Hoh R, Martin JN, Nixon DF, McCune JM, Deeks S. Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment. J Virol 2005 79:14169-78. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16254352
  2. Baum PD, McCune JM. Direct measurement of T cell receptor repertoire diversity with AmpliCot. Nat Methods 2006 3:895-901.
  3. Deeks SG, Schweighardt B, Wrin T, Galovich J, Hoh R, Sinclair E, Hunt P, McCune JM, Martin JN, Petropoulos C, Hecht FM. Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses. J Virol 2006 80:6155-64. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16731954
  4. Hanley MB, Sinclair E, Navarro W, Keir M, McCune JM. A novel serum-free bone marrow microaggregate culture system. J Stem Cells 2006 1:23-4.
  5. Hsue PY, Hunt PW, Sinclair E, Bredt B, Franklin A, Killian M, Hoh R, Martin JN, McCune JM, Waters DD, Deeks SG. Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses. AIDS 2006 20:2275-83.
  6. Hunt PW, Harrigan PR, Huang W, Bates M, Williamson DW, McCune JM, Price RW, Spudich SS, Lampiris H, Hoh R, Liegler T, Neilands TB, Martin JN, Deeks SG. Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremia. J Infect Dis 2006 194:926-30.
  7. Michaelsson J, Mold JE, McCune JM, Nixon DF. Regulation of T cell responses in the developing human fetus. J Immunol 2006 176: 5741-8.
  8. Nomura LE, Emu B, Hoh R, Haaland P, Deeks SG, Martin JN, McCune JM, Nixon DF, Maecker HT. IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells. AIDS Res Ther2006 3:18. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16859558
  9. Papasavvas E, Kostman JR, Thiel B, Pistilli M, Mackiewicz A, Foulkes A, Gross R, Jordan KA, Nixon DF, Grant R, Poulin JF, McCune JM, Mounzer K, Montaner LJ. HIV-1-specific CD4+ T cell responses in chronically HIV-1 infected blippers on antiretroviral therapy in relation to viral replication following treatment interruption. J Clin Immunol 2006 1:40-54.
  10. Red-Horse, K, Rivera J, Schanz A, Zhou Y, Winn V, Kapidzic M, Maltepe E. Okazaki K, Kochman R, Vo KC, Giudice L, Erlebacher A, McCune JM, Stoddart CA, Fisher SJ. Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation. J Clin Invest 2006 116:2643-52, 2006. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16998586
  11. Abrams DI, Shade SB, Couey P, McCune JM, Lo J, Bacchetti P, Chang B, Epling L, Liegler T, Grant RM. Dehydroepiandrosterone (DHEA) effects on HIV-1 replication and host immunity: a randomized placebo-controlled study. AIDS Res Human Retroviruses 2007 23:77-85.
  12. Hartigan-O'Connor DJ, Abel K, McCune JM. Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression. J Exp Med 2007;204:2679-92. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17954571
  13. Hartigan-O’Connor DJ, Poon CK, Sinclair E, McCune JM. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods 2007 319:41-52.
  14. Miller CJ, Genesca M, Abel K, Montefiore D, Forthal D, Bost K, Li J, Favre D, McCune JM. Antiviral antibodies are necessary for control of simian immunodeficiency virus replication. J Virol 2007 81:5024-35.
  15. Owen RE, Sinclair E, Emu B, Heitman JW, Hirschkorn DF, Epling CL, Tan QX, Custer B, Harris JM, Jacobson MA, McCune JM, Martin JN, Hecht FM, Deeks SG, Norris PJ. Loss of T cell responses following long-term cryopreservation. J Immunol Methods 2007;326:93-115.
  16. Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression. Proc Natl Acad Sci U S A 2008;105:8718-23.
  17. Emu B, Sinclair E, Hatano H, Ferre A, Shacklett B, Martin JN, McCune JM, Deeks SG. HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control. J Virol 2008;82:5398-407.
  18. Hunt PW, Brenchley J, Sinclair E, McCune JM, Roland M, Page-Shafer K, Hsue P, Emu B, Krone M, Lampiris H, Douek D, Martin JN, Deeks SG. Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy. J Infect Dis 2008;197:126-33.
  19. Kanwar B, Gao DW, Hwang AB, Grenert JP, Williams SP, Franc B, McCune JM. In vivo imaging of mucosal CD4+ T cells using single photon emission computed tomography in a murine model of colitis. J Immunol Methods 2008;329:21-30.
  20. Ladell K, Hellerstein MK, Cesar D, Busch R, Boban D, McCune JM. Central memory CD8(+) T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression. J Immunol 2008;180:7907-18.
  21. Malleret B, Karlsson I, Maneglier B, Brochard P, Delache B, Andrieu T, Muller-Trutwin M, Beaumont T, McCune JM, Banchereau J, Le Grand R, Vaslin B. Effect of SIVmac infection on plasmacytoid and CD1c+ myeloid dendritic cells in cynomolgus macaques. Immunology 2008;124:223-33.
  22. Napolitano LA, Schmidt D, Gotway MB, Ameli N, Filbert EL, Ng MM, Clor JL, Epling L, Sinclair E, Baum PD, Li K, Killian ML, Bacchetti P, McCune JM. Growth hormone enhances thymic function in HIV-1-infected adults. J Clin Invest 2008;118:1085-98. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18292808
  23. Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune JM, Bredt BM, Stablein DM, Stock PG. HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes. Am J Transplant 2008;8:355-65.
  24. Schweneker M, Favre D, Martin JN, Deeks SG, McCune JM. HIV-induced changes in T cell signaling pathways. J Immunol 2008;180:6490-500.

Steven L. McKnight

  1. Tu BP, Kudlicki A, Rowicka M, McKnight SL. Logic of the yeast metabolic cycle: Temporal compartmentalization of cellular processes. Science 2005 310:1152-8.
  2. Franken P, Dudley CA, Estill SJ, Barakat M, Thomason R, O’Hara BF, McKnight SL. NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions. Proc Natl Acad Sci U S A 2006 103:7118-23. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16636276
  3. Chen Z, McKnight SL. A conserved DNA damage response pathway responsible for coupling the cell division cycle to the circadian and metabolic cycles. Cell Cycle 2007;6:2906-12.
  4. Chen Z, Odstrcil EA, Tu BP, McKnight SL. Restriction of DNA replication to the reductive phase of the metabolic cycle protects genome integrity. Science 2007;316:1916-9.
  5. Tu BP, Mohler RE, Liu JC, Dombek KM, Young ET, Synovec RE, McKnight SL. Cyclic changes in metabolic state during the life of a yeast cell. Proc Natl Acad Sci U S A 2007;104:16886-91. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17940006
  6. Williams NS, Burgett AW, Atkins AS, Wang X, Harran PG, McKnight SL. Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity. Proc Natl Acad Sci U S A 2007 104:2074-9. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17287337

Chad Mirkin

  1. Georganopoulou D, Chang L, Nam J-M, Thaxton CS, Mufson EJ, Klein WL, Mirkin CA. Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Proc Natl Acad Sci U S A 2005 103:2273-6. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15695586
  2. Liu X, Zhang Y, Goswami OK, Okasinski JS, Salaita K, Sun P, Bedzyk MJ, Mirkin CA. The controlled evolution of a polymer single crystal. Science 2005 307:1763-6.
  3. Salaita KS, Lee SW, Wang X, Huang L, Dellinger TM, Liu C, Mirkin CA. Sub-100nm, centimeter scale, parallel dip-pen nanolithography. Small 2005 1:940-5.
  4. Shaikh KA, Ryu KS, Goluch ED, Nam J-M, Liu J, Thaxton CS, Chiesl TN, Barren AE, Lu Y, Mirkin CA, Liu C. A modular microfluidic architecture for integrated biochemical analysis. Proc Natl Acad Sci U S A 2005 102:9745-50. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15985549
  5. Stoeva SI, Huo F, Lee J-S, Mirkin CA. Three-layer composite magnetic nanoparticle probes for DNA. J Am Chem Soc 2005 127:15362-3.
  6. Thaxton CS, Hill HD, Georganopoulou DG, Stoeva SI, Mirkin CA. A bio-bar-code assay based upon dithiothreitol-induced oligonucleotide release. Anal Chem 2005 77:8174-8.
  7. Vega RA, Maspoch D, Salaita K, Mirkin CA. Nanoarrays of single virus particles. Angew Chem 2005 44:6013-5.
  8. Han MS, Lytton-Jean AK, Mirkin CA. A gold nanoparticle based approach for screening triplex DNA binders. J Am Chem Soc 2006 128:4954-5.
  9. Han MS, Lytton-Jean AK, Oh B-K, Heo J, Mirkin CA. Colorimetric screening of DNA-binding molecules with gold nanoparticle probes. Angew Chem Int Ed 2006 45:1807-10.
  10. Han MS, Lytton-Jean AK, Oh BK, Heo J, Mirkin CA. Colorimetric screening of DNA binding molecules with gold nanoparticle probes. Angew Chem 2006 45:1807-10.
  11. Hill HD, Mirkin CA. The bio-barcode assay for the detection of protein and nucleic acid targets using DTT-induced ligand exchange. Nat Protoc 2006 1:324-36.
  12. Huo F, Lytton-Jean AK, Mirkin CA. Asymmetric functionalization of nanoparticles based on thermally addressable DNA interconnects. Adv Mater 2006 18:2304-6.
  13. Hurst SJ, Lytton-Jean AK, Mirkin CA. Maximizing DNA loading on a range of gold nanoparticle sizes. Anal Chem 2006 78:8313-8.
  14. Hurst SJ, Payne EK, Qin L, Mirkin CA. Multi-component one-dimensional nanostructures. Angew Chem. 2006 45:2672-92.
  15. Hurst SJ, Payne EK, Qin L, Mirkin CA. Multisegmented one-dimensional nanorods prepared by hard-template synthetic methods. Angew Chem Int Ed 2006 45:2672-92.
  16. Jin R, Cao YC, Thaxton CS, Mirkin CA. Glass-bead-based parallel detection of DNA using composite Raman labels. Small 2006 2:375-80.
  17. Lee J-S, Stoeva SI, Mirkin CA. DNA-induced size-selective separation of mixtures of gold nanoparticles. J Am Chem Soc 2006 128:8899-903.
  18. Lee SW, Oh B-K, Sanedrin RG, Salaita K, Fujigaya T, Mirkin CA. Biologically active protein nanoarrays generated using parallel dip-pen nanolithography. Adv Mat 2006 18:1133-36.
  19. Oh B-K, Nam JM, Lee SW, Mirkin CA. A fluorophore-based bio-barcode amplification assay for proteins. Small 2006 2:103-8.
  20. Oh B-K, Park S, Millstone JE, Lee SW, Lee K-B, Mirkin CA. Separation of tricomponent protein mixtures with triblock nanorods. J Am Chem Soc 2006 128:11825-9.
  21. Oh BK, Park S, Millstone JE, Lee SW, Lee KB, Mirkin CA. Separation of tricomponent protein mixtures with triblock nanorods. J Am Chem Soc 2006 128:11825-9.
  22. Park SY, Lee JS, Georganopoulou D, Mirkin CA, Schatz GC. Structures of DNA-linked nanoparticle aggregates. J Phys Chem B 2006 770: 12673-81.
  23. Payne EK, Shuford KL, Park S, Schatz GC, Mirkin CA. Multipole plasmon resonances in gold nanorods. J Phys Chem B Condens Matter Mater Surf Interfaces Biophys 2006 110:2150-4.
  24. Payne EK, Shuford KL, Park S, Schatz GC, Mirkin CA. Multipole plasmon resonances in gold nanorods. J Phys Chem B 2006 110:2150-4.
  25. Qin L, Zou S, Xue C, Atkinson A, Schatz GC, Mirkin CA. Designing, fabricating, and imaging Raman hot spots. Proc Natl Acad Sci U S A 2006 103:13300-3.
  26. Rosi NL, Giljohann DA, Thaxton CS, Lytton-Jean AK, Han MS, Mirkin CA. Oligonucleotide-modified gold nanoparticles for intracellular gene regulation. Science 2006 312:1027-30.
  27. Stoeva SI, Lee J-S, Smith JE, Rosen ST, Mirkin CA. Multiplexed detection of protein cancer markers with biobarcoded nanoparticle probes. J Am Chem Soc 2006 128:8378-9.
  28. Stoeva SI, Lee J-S, Thaxton CS, Mirkin CA. Multiplexed DNA detection with biobarcoded nanoparticle probes. Angew Chem Int Ed 2006 45:3303-6.
  29. Vega RA, Maspoch D, Shen CK, Kakkassery JJ, Chen BJ, Lamb RA, Mirkin CA. Functional antibody arrays through metal ion-affinity templates. Chembiochem 2006 7:1653-7.
  30. Xu X, Rosi NL, Wang Y, Huo F, Mirkin CA. Asymmetric functionalization of gold nanoparticles with oligonucleotides. J Am Chem Soc 2006 128:9286-7.
  31. Farha OK, Spokoyny AM, Mulfort KL, Hawthorne MF, Mirkin CA, Hupp JT. Synthesis and hydrogen sorption properties of carborane based metal-organic framework materials. J Am Chem Soc 2007;129:12680-1.
  32. Giljohann DA, Seferos DS, Patel PC, Millstone JE, Rosi NL, Mirkin CA. Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles. Nano Lett 2007;7:3818-21.
  33. Hill HD, Vega RA, Mirkin CA. Nonenzymatic detection of bacterial genomic DNA using the bio bar code assay. Anal Chem 2007;79:9218-23.
  34. Hurst SJ, Han MS, Lytton-Jean AK, Mirkin CA. Screening the sequence selectivity of DNA-binding molecules using a gold nanoparticle-based colorimetric approach. Anal Chem 2007;79:7201-5.
  35. Jang JW, Maspoch D, Fujigaya T, Mirkin CA. A Molecular Erraser for Dip-Pen Nanolithography. Small 2007;3:600-5.
  36. Kuwabara J, Stern CL, Mirkin CA. A coordination chemistry approach to a multieffector enzyme mimic. J Am Chem Soc 2007;129:10074-5.
  37. Lee JS, Han MS, Mirkin CA. Colorimetric detection of mercuric ion (Hg2+) in aqueous media using DNA-functionalized gold nanoparticles. Angew Chem Int Ed Engl 2007;46:4093-6.
  38. Lee JS, Lytton-Jean AK, Hurst SJ, Mirkin CA. Silver nanoparticle-oligonucleotide conjugates based on DNA with triple cyclic disulfide moieties. Nano Lett 2007;7:2112-5.
  39. Lytton-Jean AK, Han MS, Mirkin CA. Microarray detection of duplex and triplex DNA binders with DNA-modified gold nanoparticles. Anal Chem 2007;79:6037-41. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17614366
  40. Qin L, Banholzer MJ, Millstone JE, Mirkin CA. Nanodisk codes. Nano Lett 2007;7:3849-53.
  41. Qin L, Banholzer MJ, Xu X, Huang L, Mirkin CA. Rational design and synthesis of catalytically driven nanorotors. J Am Chem Soc 2007;129:14870-1.
  42. Qin L, Jang JW, Huang L, Mirkin CA. Sub-5-nm gaps prepared by on-wire lithography: correlating gap size with electrical transport. Small 2007 3:86-90.
  43. Salaita K, Wang Y, Mirkin CA. Applications of dip-pen nanolithography. Nat Nanotechnol 2007;2:145-55.
  44. Seferos DS, Giljohann DA, Hill HD, Prigodich AE, Mirkin CA. Nano-flares: probes for transfection and mRNA detection in living cells. J Am Chem Soc 2007;129:15477-9.
  45. Seferos DS, Giljohann DA, Rosi NL, Mirkin CA. Locked nucleic acid-nanoparticle conjugates. Chembiochem 2007;8:1230-2.
  46. Ulmann PA, Brown AM, Ovchinnikov MV, Mirkin CA, DiPasquale AG, Rheingold AL. Spontaneous formation of heteroligated PtII complexes with chelating hemilabile ligands. Chemistry 2007;13:4529-34.
  47. Vega RA, Shen CK, Maspoch D, Robach JG, Lamb RA, Mirkin CA. Monitoring single-cell infectivity from virus-particle nanoarrays fabricated by parallel dip-pen nanolithography. Small 2007;3:1482-5.
  48. Xu X, Georganopoulou DG, Hill HD, Mirkin CA. Homogeneous detection of nucleic acids based upon the light scattering properties of silver-coated nanoparticle probes. Anal Chem 2007;79:6650-4.
  49. Xu X, Han MS, Mirkin CA. A gold-nanoparticle-based real-time colorimetric screening method for endonuclease activity and inhibition. Angew Chem Int Ed Engl 2007;46:3468-70.
  50. Xue C, Chen X, Hurst SJ, Mirkin CA. Self-Assembled Monolayer Mediated Silica Coating of Silver Triangular Nanoprisms. Adv Mater 2007;19:4071-4.
  51. Xue C, Millstone JE, Li S, Mirkin CA. Plasmon-driven synthesis of triangular core-shell nanoprisms from gold seeds. Angew Chem Int Ed Engl 2007;46:8436-9.
  52. Yoon HJ, Heo J, Mirkin CA. Allosteric regulation of phosphate diester transesterification based upon a dinuclear zinc catalyst assembled via the weak-link approach. J Am Chem Soc 2007;129:14182-3.
  53. Zou S, Maspoch D, Wang Y, Mirkin CA, Schatz GC. Rings of single-walled carbon nanotubes: molecular-template directed assembly and Monte Carlo modeling. Nano Lett 2007;7:276-80.
  54. Chen X, Jeon YM, Jang JW, Qin L, Huo F, Wei W, Mirkin CA. On-wire lithography-generated molecule-based transport junctions: a new testbed for molecular electronics. J Am Chem Soc 2008;130:8166-8.
  55. Hill HD, Macfarlane RJ, Senesi AJ, Lee B, Park SY, Mirkin CA. Controlling the Lattice Parameters of Gold Nanoparticle FCC Crystals with Duplex DNA Linkers. Nano Lett 2008;8:2341-4.
  56. Kuwabara J, Ovchinnikov MV, Stern CL, Mirkin CA. The Reactivity of Dinuclear Rhodium(l) Macrocycles Formed via the Weak-Link Approach. Organometallics 2008;27:787-92.
  57. Lee JS, Seferos DS, Giljohann DA, Mirkin CA. Thermodynamically controlled separation of polyvalent 2-nm gold nanoparticle-oligonucleotide conjugates. J Am Chem Soc 2008;130:5430-1.
  58. Lee JS, Ulmann PA, Han MS, Mirkin CA. A DNA-gold nanoparticle-based colorimetric competition assay for the detection of cysteine. Nano Lett 2008;8:529-33.
  59. Millstone JE, Wei W, Jones MR, Yoo H, Mirkin CA. Iodide ions control seed-mediated growth of anisotropic gold nanoparticles. Nano Lett 2008;8:2526-9.
  60. Oliveri CG, Ulmann PA, Wiester MJ, Mirkin CA. Heteroligated Supramolecular Coordination Complexes Formed via the Halide-Induced Ligand Rearrangement Reaction. Acc Chem Res 2008.
  61. Park SY, Lytton-Jean AK, Lee B, Weigand S, Schatz GC, Mirkin CA. DNA-programmable nanoparticle crystallization. Nature 2008;451:553-6.
  62. Sanedrin RG, Huang L, Jang JW, Kakkassery J, Mirkin CA. Polyethylene glycol as a novel resist and sacrificial material for generating positive and negative nanostructures. Small 2008;4:920-4.
  63. Xu X, Zhao Z, Qin L, Wei W, Levine JE, Mirkin CA. Fluorescence recovery assay for the detection of protein-DNA binding. Anal Chem 2008;80:5616-21.
  64. Xue C, Metraux GS, Millstone JE, Mirkin CA. Mechanistic study of photomediated triangular silver nanoprism growth. J Am Chem Soc 2008;130:8337-44.
  65. Zheng G, Daniel WL, Mirkin CA. A new approach to amplified telomerase detection with polyvalent oligonucleotide nanoparticle conjugates. J Am Chem Soc 2008;130:9644-5.
  66. Zheng G, Qin L, Mirkin CA. Spectroscopically enhancing electrical nanotraps. Angew Chem Int Ed Engl 2008;47:1938-41.

Rob Phillips

  1. Dupuy LM, Tadmr oEB, Miller RE, Phillips R. Finite-temperature quasicontinuum: molecular dynamics without all the atoms. Phys Rev Lett Epub 2005 Aug 5, 95:060202.
  2. Wiggins PA, Phillips R, Nelson PC. Exact theory of kinkable elastic polymers. Phys Rev E Stat Nonlin Soft Matter Phys Epub 2005 Feb 23, 71(2 Pt 1):021909.
  3. Ghosh K, Dill KA, Inamdar MA, Seitaridou E, Phillips R. Teaching the principles of statistical dynamics. Am J Phys 2006 74:123-33.
  4. Grayson P, Evilevitch A, Inamdar MM, Purohit PK, Gelbart WM, Knobler CM, Phillips R. The effect of genome length on ejection forces in bacteriophage lambda. Virology 2006 348:430-6.
  5. Inamdar MM, Gelbart WM, Phillips R. Dynamics of DNA ejection from bacteriophage. Biophys J 2006 91:411-20. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16679360
  6. Segall DE, Nelson PC, Phillips R. Volume-exclusion effects in tethered-particle experiments: bead size matters. Phys Rev Lett Epub 2006 Mar 3, 96:088306.
  7. Garcia HG, Grayson P, Han L, Inamdar M, Kondev J, Nelson PC, Phillips R, Widom J, Wiggins PA. Biological consequences of tightly bent DNA: the other life of a macromolecular celebrity. Biopolymers 2007;85:115-30.
  8. Seitaridou E, Inamdar MM, Phillips R, Ghosh K, Dill K. Measuring flux distributions for diffusion in the small-numbers limit. J Phys Chem B 2007 111:2288-92.
  9. Ursell T, Huang KC, Peterson E, Phillips R. Cooperative gating and spatial organization of membrane proteins through elastic interactions. PLoS Comput Biol 2007 3(5):e81. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17480116
  10. Phillips R. Biology By the Numbers. In: Zewail A, ed. Physical Biology: From Atoms to Medicine: Imperial College Press; 2008.

Stephen R. Quake

  1. Anderson, M. J., C. L. Hansen, et al. (2006). "Phase knowledge enables rational screens for protein crystallization." Proc Natl Acad Sci U S A 103(45): 16746-51. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17075056
  2. Liu, J., B. A. Williams, et al. (2006). "Enhanced signals and fast nucleic acid hybridization by microfluidic chaotic mixing." Angew Chem Int Ed Engl 45(22): 3618-23.
  3. Ma, Z., J. M. Gerton, et al. (2006). "Fluorescence near-field microscopy of DNA at sub-10 nm resolution." Phys Rev Lett 97(26): 260801.
  4. Ottesen, E. A., J. W. Hong, et al. (2006). "Microfluidic digital PCR enables multigene analysis of individual environmental bacteria." Science 314(5804): 1464-7.
  5. Warren, L., D. Bryder, et al. (2006). "Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR." Proc Natl Acad Sci U S A 103(47): 17807-12. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17098862
  6. Gomez-Sjoberg R, Leyrat AA, Pirone DM, Chen CS, Quake SR. Versatile, fully automated, microfluidic cell culture system. Anal Chem 2007;79:8557-63.
  7. Huang, Y., P. Castrataro, et al. (2007). "Solvent resistant microfluidic DNA synthesizer." Lab Chip 7(1): 24-6.
  8. Maerkl, S. J. and S. R. Quake (2007). "A systems approach to measuring the binding energy landscapes of transcription factors." Science 315(5809): 233-7.
  9. Marcy, Y., C. Ouverney, et al. (2007). "Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth." Proc Natl Acad Sci U S A 104(29): 11889-94.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17620602

Sunney Xie

  1. Evans CL, Potma EO, Puoris'haag M, Cote D, Lin CP, Xie XS. Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy. Proc Natl Acad Sci U S A 2005 102:6807. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16263923
  2. Kou SC, Cherayil BJ, Min W, English BP, Xie XS. Single-molecule Michaelis-Menten equations. Phys Chem BCondens Matter Mater Surf Interfaces Biophys 2005 109:19068-81.
  3. Min W, English BP, Luo G, Cherayil BJ, Kou SC, Xie XS. Fluctuating enzymes: Lessons from single-molecule studies. Ace Chem Res 2005 38:923-31.
  4. Blainey PC, van Oijen AM, Banerjee A, Verdine GL, Xie XS. A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proc Natl Acad Sci U S A 2006 103:5752-7.
  5. Cai L, Friedman N, Xie XS. Stochastic protein expression in individual cells at the single molecule level. Nature 2006 440:358-62.
  6. English BP, Min W, van Oijen AM, Lee KT, Luo G, Sun H, Cherayil BJ, Kou SC, Xie XS. Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited. Nat Chem Bio 2006 2:87.
  7. Ganikhanov F, Carrasco S, Xie XS, Katz M, Seitz W, Kopf D. Broadly tunable dual-wavelength light source for coherent anti-Stokes Raman scattering microscopy. Opt Lett 2006 31:1292-4.
  8. Ganikhanov F, Evans CL, Saar BG, Xie XS. High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy. Opt Lett 2006 31:1872-4.
  9. Legare F, Evans CL, Ganikhanov F, Xie XS. Towards CARS endoscopy. Opt Express 2006 14:4427-32.
  10. Nan, Xiaolin; Potma, Eric O.; Xie, X. Sunney, Nonperturbative Chemical Imaging of Organelle Transport in Living Cells with Coherent anti-Stokes Raman Scattering Microscopy, Biophys. J., 91, 728-735 (2006). http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16632501
  11. Xie XS, Yu J, Yang WY. Living cells as test tubes. Science 2006 312:228-30.
  12. Yu J, Xiao J, Ren X, Lao K, Xie XS. Probing gene expression in live cells, one protein molecule at a time. Science 2006 311:1600-3.
  13. Friedman, Nir; Cai, Long; Xie, X. Sunney, Linking Stochastic Dynamics to Population Distribution: An Analytical Framework of Gene Expression, Phys. Rev. Lett. 97, 168302 (2006).
  14. Elf J, Li GW, Xie XS. Probing transcription factor dynamics at the single-molecule level in a living cell. Science 2007;316:1191-4.
  15. Evans CL, Xu X, Kesari S, Xie XS, Wong STC, Young GS. Chemically-slective Imaging of Brain Structures with CARS Microscopy. Optics Express 2007;15:12076-87.
  16. Kim S, Blainey PC, Schroeder CM, Xie XS. Multiplexed single-molecule assay for enzymatic activity on flow-stretched DNA. Nat Methods 2007;4:397-9.
  17. Wright AJ, Poland SP, Girkin JM, Freudiger CW, Evans CL, Xie XS. Adaptive Optics for Enhanced Signal in CARS microscopy. Optics Express 2007;15:18209-19.
  18. Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, Zhu H, Yu AD, Xie X, Ma D, Yuan J. Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A 2007;104:19023-8. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18024584
  19. Bagchi B, Blainey PC, Xie XS. Diffusion constant of a nonspecifically bound protein undergoing curvilinear motion along DNA. J Phys Chem B 2008;112:6282-4.
  20. Min W, Xie XS, Bagchi B. Two-dimensional reaction free energy surfaces of catalytic reaction: effects of protein conformational dynamics on enzyme catalysis. J Phys Chem B 2008;112:454-66.
  21. Nan X, Sims PA, Xie XS. Organelle tracking in a living cell with microsecond time resolution and nanometer spatial precision. Chemphyschem 2008;9:707-12.
  22. Xie XS, Choi PJ, Li GW, Lee NK, Lia G. Single-molecule approach to molecular biology in living bacterial cells. Annu Rev Biophys 2008;37:417-44.

Up to Top

2005 PIONEER AWARD RECIPIENTS

Vicki L. Chandler

  1. Alleman, M., Sidorenko, L., McGinnis, K., Seshadri, V., Dorweiler, J.E., White, J., Sikkink, K., and Chandler, V.L. (2006) An RNA-dependent RNA polymerase is required for paramutation in maize. Nature, Jul 20;442(7100):295-8.
  2. Ames D, Murphy N, Helentjaris T, Sun N, Chandler V. Comparative analyses of human single- and multilocus tandem repeats. Genetics 2008;179:1693-704.
  3. Chandler V, Alleman M. Paramutation: epigenetic instructions passed across generations. Genetics 2008;178:1839-44.

Hollis T. Cline

  1. Akerman AJ, Cline HT. Depolarizing GABAergic conductances regulate the balance of excitation to inhibition in the developing retinotectal circuit in vivo. J Neurosci 2006 26:5117-30.
  2. Haas K, Li J, Cline HT. (2006) AMPA receptors regulate experience-dependent dendritic arbor growth in vivo. Proc Natl Acad Sci U S A 2006 103:12127-31. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16882725
  3. Ruthazer ES, Li J, Cline HT. Stabilization of axon branch dynamics by synaptic maturation. J Neurosci 2006 26:3594-603.
  4. Van Keuren-Jensen K, Cline HT. Visual experience regulates metabotropic glutamate receptor-regulated plasticity of AMPA receptor transmission by homer1a induction. J Neurosci 2006 26:7575-80.

Leda Cosmides

  1. Cosmides L, Tooby J. Neurocognitive adaptations designed for social exchange. In Buss DM (Ed.), The Handbook of Evolutionary Psychology (pp 584-627). 2005 Hoboken NJ: Wiley.
  2. Cosmides L, Tooby J, Fiddick L, Bryant G. Detecting cheaters. Trends Cogn Sci 2005 9:505-6.
  3. Tooby J, Cosmides L. Conceptual foundations of evolutionary psychology. In Buss DM (Ed.), The Handbook of Evolutionary Psychology (pp 5-67). 2005 Hoboken NJ: Wiley.
  4. Tooby J, Cosmides L, Barrett HC. Resolving the debate on innate ideas: Learnability constraints and the evolved interpenetration of motivational and conceptual functions. In Carruthers P, Laurence S, Stich S (Eds.), The Innate Mind: Structure and Content (pp 305-37). 2005 NY: Oxford University Press.
  5. Barrett. H. C., Cosmides, L., & Tooby, J. (2006). The hominid entry into the cognitive niche. (pp. 241-248). In S. Gangestad & J. Simpson (Eds.), The Evolution of Mind. NY: Guilford.
  6. Cosmides L. The cognitive revolution: The next wave. APS Observer 2006 19:7, 23.
  7. Cosmides L, Tooby J. Evolutionary psychology, moral heuristics, and the law. In Gigerenzer G, Engel C (Eds.), Heuristics and the Law (Dahlem Workshop Report 94). 2006 Cambridge MA: MIT Press.
  8. Ermer, E., Cosmides, L. & Tooby, J. (2006). Functional specialization and the adaptationist program. (pp. 153-160). In S. Gangestad & J. Simpson (Eds.), The Evolution of Mind. NY: Guilford.
  9. Ermer, E., Guerin, S., Cosmides, L., Tooby, J., Miller M. (2006). Theory of Mind Broad and Narrow: Reasoning about social exchange engages TOM areas, precautionary reasoning does not. Social Neuroscience, 1(3-4), 196-219. (Co-published as chapter inTheory of Mind. (R. Saxe & S. Baron-Cohen, eds.). Psychology Press/Taylor & Francis Group.)
  10. Tooby, J. & Cosmides, L. (2006). The evolved architecture of hazard management: risk detection reasoning and the motivational computation of threat magnitudes. Comment on Boyer & Lienard. Behavioral and Brain Sciences 29(6), 631-633.
  11. Tooby J, Cosmides L, Price M. Cognitive adaptations for n-person exchange: The evolutionary roots of organizational behavior. Managerial and Decision Economics 2006 27:103-29.
  12. Ermer E, Cosmides L, Tooby J. Cheater detection mechanism. In: Vohs K, Baumeister R, eds. Encyclopedia of Social Psychology: Sage Publications; 2007.
  13. Lieberman, D., Tooby, J. & Cosmides, L. (2007). The architecture of human kin detection. Nature, 445 (7129), 727-731. (15 February 2007) + Supplementary Information.
  14. New J, Cosmides L, Tooby J. Category-specific attention for animals reflects ancestral priorities, not expertise. Proc Natl Acad Sci U S A 2007;104:16598-603. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17909181
  15. Tooby, J. & Cosmides, L. (2007). Evolutionary psychology, ecological rationality, and the unification of the behavioral sciences. Behavioral and Brain Sciences 30(1), 42-43.
  16. Cosmides L, Tooby J. Can a general deontic logic capture the facts of human moral reasoning? How the mind interprets social exchange rules and detects cheaters. In: Sinnott-Armstrong W, ed. Moral psychology. Cambridge, MA: MIT Press; 2008:53-119.
  17. Cosmides L, Tooby J. Can evolutionary psychology assist logicians? A reply to Mallon. In: Sinnott-Armstrong, ed. Moral pscyhology. Cambridge, Ma: MIT Press; 2008:131-6.
  18. Cosmides L, Tooby J. When falsification strikes: A reply to Fodor. In: Sinnott-Armstrong W, ed. Moral psychology. Cambridge, MA: MIT Press; 2008.
  19. Enner E, Cosmides L, Tooby J. Relative status regulates risky decision making about resources in men: evidence for the co-evolution of motivation and cognition. Evolution and Human Behavior 2008;29:106-18.
  20. Tooby J, Cosmides L. The evolutionary psychology of the emotions and their relationship to internal regulatory variables. In: Lewis M, Haviland-Jones JM, eds. Handbook of emotions. 3rd ed. New York: Guilford; 2008.

Titia de Lange

  1. Konishi A, de Lange T. Cell cycle control of telomere protection and NHEJ revealed by a ts mutation in the DNA-binding domain of TRF2. Genes Dev 2008;22:1221-30. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18451109

Karl Deisseroth

  1. Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci 2005 8:1263-8.
  2. Deisseroth K., Feng G., Majewska A., Ting A.E., Miesenböck G., and Schnitzer M.J. (2006). Next-generation optical technologies. Journal of Neuroscience 26, 10380-6.
  3. Zhang F., Wang, L.P., Boyden E.S., and Deisseroth K. (2006). Channelrhodopsin-2 and optical control of excitable cells. Nature Methods 3, 785-792.
  4. Adamantidis AR, Zhang F, Aravanis AM, Deisseroth K, de Lecea L. Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature 2007;450:420-4.
  5. Airan RD, Hu ES, Vijaykumar R, Roy M, Meltzer LA, Deisseroth K. Integration of light-controlled neuronal firing and fast circuit imaging. Curr Opin Neurobiol 2007;17:587-92.
  6. Airan RD, Meltzer LA, Roy M, Gong Y, Chen H, Deisseroth K. High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Science 2007;317:819-23.
  7. Aravanis AM, Wang LP, Zhang F, Meltzer LA, Mogri MZ, Schneider MB, Deisseroth K. An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J Neural Eng 2007;4:S143-56.
  8. Gradinaru V, Thompson KR, Zhang F, Mogri M, Kay K, Schneider MB, Deisseroth K. Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci 2007;27:14231-8. http://www.jneurosci.org/cgi/content/full/27/52/14231
  9. Zhang F., Wang, L.P., Brauner M., Liewald J.F., Kay K., Watzke N., Wood P.G., Bamberg E., Nagel G., Gottschalk A., and Deisseroth K. (2007). Multimodal fast optical interrogation of neural circuitry. Nature 446, 633-639.
  10. Zhang F, Prigge M, Beyriere F, Tsunoda SP, Mattis J, Yizhar O, Hegemann P, Deisseroth K. Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. Nat Neurosci 2008;11:631-3.

Pehr A.B. Harbury

  1. Boas FE, Harbury PB. Design of protein-ligand binding based on the molecular-mechanics energy model. J Mol Biol 2008;380:415-24.
  2. Wrenn SJ, Harbury PB. Chemical evolution as a tool for molecular discovery. Annu Rev Biochem 2007;76:331-49.

Erich D. Jarvis

  1. Jarvis ED. Selection for and against vocal learning in birds and mammals. Ornithology Science 2006 5:5-14.
  2. Sasaki A, Sotnikova TD, Gainetdinov RR, Jarvis ED. Social context-dependent singing-regulated dopamine J Neurosci 2006 26:9010-4.
  3. Wada K, Howard JT, McConnell P, Lints T, Rivas MV, Whitney O, Horita H, Patterson MA, White SA, Scharff C, Heasler S, Zhao S, Sakaguchi H, Hagiwara M, Shiraki T, Hirozane-Kishikawa T, Skene P, Hayashizaki Y, Carninci P, Jarvis ED. A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes. Proc Natl Acad Sci U S A 2006 103:15212-7.
  4. Hara E, Kubikova L, Hessler NA, Jarvis ED. Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context. (2007) Eur. J. Neurosci. 25:3406-3416
  5. Kubikova L, Turner E, Jarvis ED. The pallial-basal ganglia pathway modulates the behaviorally-driven gene expression of the motor pathway. (2007) Eur. J. Neurosci. 25:1915-2247.
  6. Feenders G, Liedvogel M, Rivas M, Zapka M, Horita H, Hara E, Wada K, Mouritsen H, Jarvis ED. Molecular mapping of movement-associated areas in the avian brain: a motor theory for vocal learning origin. PLoS ONE 2008;3:e1768. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18335043

Thomas A. Rando

  1. Conboy IM, Rando TA. Aging, stem cells, and tissue regeneration: Lessons from muscle. Cell Cycle 2005 4:407-10.
  2. Dhawan J, Rando TA. Stem cells in postnatal myogenesis: Molecular mechanisms of satellite cell quiescence, activation, and replenishment. Trends Cell Biol 2005 15:666-73.
  3. Luo D, Renault VM, Rando TA. The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis. Semin Cell Devel Biol 2005 16:612-22.
  4. Rando TA. The adult muscle stem cell comes of age. Nat Med 2005 11:829-31.
  5. Shi L, Zhao G, Qiu D, Godfrey WR, Vogel H, Rando TA, Hu H, Kao PN. NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3'-untranslated region of p21WAF1/CIPI and MyoD mRNAs. J Biol Chem 2005 280:18981-9.
  6. Quach NL, Rando TA. Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells. Dev Biol 2006 293:38-52.
  7. Rando TA. Prognostic value of telomere length: the long and short of it. Ann Neurol 2006;60:155-7.
  8. Boutet SC, Disatnik MH, Chan LS, Iori K, Rando TA. Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors. Cell 2007;130:349-62.
  9. Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C, Rando TA. Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science 2007;317:807-10.
  10. Brunet A, Rando TA. Ageing: from stem to stern. Nature 2007;449:288-91.
  11. Boutet SC, Rando TA. [Proteasomal degradation of Pax3 in skeletal muscle progenitors: one ubiquitin does the trick!]. Med Sci (Paris) 2008;24:31-3.
  12. Brack AS, Conboy IM, Conboy MJ, Shen J, Rando TA. A temporal switch from notch to Wnt signaling in muscle stem cells is necessary for normal adult myogenesis. Cell Stem Cell 2008;2:50-9.
  13. Rando TA. Get personal with gene therapy for muscular dystrophy. Lancet Neurol 2008;7:196-8.

Derek J. Smith

  1. Smith DJ. Predictability and preparedness in influenza control. Science 2006 312:392-4.
  2. de Jong JC, Smith DJ, Lapedes AS, Donatelli I, Campitelli L, Barigazzi G, Van Reeth K, Jones TC, Rimmelzwaan GF, Osterhaus AD, Fouchier RA. Antigenic and genetic evolution of swine influenza A (H3N2) viruses in Europe. J Virol 2007;81:4315-22. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17287258
  3. Philippa J, Baas C, Beyer W, Bestebroer T, Fouchier R, Smith D, Schaftenaar W, Osterhaus A. Vaccination against highly pathogenic avian influenza H5N1 virus in zoos using an adjuvanted inactivated H5N2 vaccine. Vaccine 2007;25:3800-8.
  4. Russell CA, Jones TC, Barr IG, Cox NJ, Garten RJ, Gregory V, Gust ID, Hampson AW, Hay AJ, Hurt AC, de Jong JC, Kelso A, Klimov AI, Kageyama T, Komadina N, Lapedes AS, Lin YP, Mosterin A, Obuchi M, Odagiri T, Osterhaus AD, Rimmelzwaan GF, Shaw MW, Skepner E, Stohr K, Tashiro M, Fouchier RA, Smith DJ. The global circulation of seasonal influenza A (H3N2) viruses. Science 2008;320:340-6.

Giulio Tononi

  1. Albus JS, Bekey GA, Holland JH, Kanwisher NG, Krichmar JL, Mishkin M, Modha DS, Raichle ME, Shepherd GM, Tononi G. A proposal for a Decade of the Mind initiative. Science 2007;317:1321.
  2. Douglas CL, Vyazovskiy V, Southard T, Chiu SY, Messing A, Tononi G, Cirelli C. Sleep in Kcna2 knockout mice. BMC Biol 2007;5:42. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17925011
  3. Esser SK, Hill SL, Tononi G. Sleep homeostasis and cortical synchronization: I. Modeling the effects of synaptic strength on sleep slow waves. Sleep 2007;30:1617-30. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18246972
  4. Feredoes E, Tononi G, Postle BR. The neural bases of the short-term storage of verbal information are anatomically variable across individuals. J Neurosci 2007;27:11003-8. http://www.jneurosci.org/cgi/content/full/27/41/11003
  5. Huber R, Esser SK, Ferrarelli F, Massimini M, Peterson MJ, Tononi G. TMS-Induced Cortical Potentiation during Wakefulness Locally Increases Slow Wave Activity during Sleep. 1: PLoS ONE. 2007:e276 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17342210
  6. Huber R, Tononi G, Cirelli C. Exploratory behavior, cortical BDNF expression, and sleep homeostasis. Sleep. 2007 30:129-39.
  7. Massimini M, Ferrarelli F, Esser SK, Riedner BA, Huber R, Murphy M, Peterson MJ, Tononi G. Triggering sleep slow waves by transcranial magnetic stimulation. Proc Natl Acad Sci U S A. 2007, 104:8496-501.
  8. Riedner BA, Vyazovskiy VV, Huber R, Massimini M, Esser S, Murphy M, Tononi G. Sleep homeostasis and cortical synchronization: III. A high-density EEG study of sleep slow waves in humans. Sleep 2007;30:1643-57. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18246974
  9. Tononi G, Cirelli C. Staying awake puts pressure on brain arousal systems. J Clin Invest 2007;117:3648-50. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18060024
  10. Vyazovskiy VV, Riedner BA, Cirelli C, Tononi G. Sleep homeostasis and cortical synchronization: II. A local field potential study of sleep slow waves in the rat. Sleep 2007;30:1631-42.
  11. Balduzzi D, Tononi G. Integrated information in discrete dynamical systems: motivation and theoretical framework. PLoS Comput Biol 2008;4:e1000091 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18551165
  12. Faraguna U, Vyazovskiy VV, Nelson AB, Tononi G, Cirelli C. A causal role for brain-derived neurotrophic factor in the homeostatic regulation of sleep. J Neurosci 2008;28:4088-95.
  13. Ferrarelli F, Massimini M, Peterson MJ, Riedner BA, Lazar M, Murphy MJ, Huber R, Rosanova M, Alexander AL, Kalin N, Tononi G. Reduced evoked gamma oscillations in the frontal cortex in schizophrenia patients: a TMS/EEG study. Am J Psychiatry 2008;165:996-1005.
  14. Ferri R, Huber R, Arico D, Drago V, Rundo F, Ghilardi MF, Massimini M, Tononi G. The slow-wave components of the cyclic alternating pattern (CAP) have a role in sleep-related learning processes. Neurosci Lett 2008;432:228-31.
  15. Huber R, Maatta S, Esser SK, Sarasso S, Ferrarelli F, Watson A, Ferreri F, Peterson MJ, Tononi G. Measures of cortical plasticity after transcranial paired associative stimulation predict changes in electroencephalogram slow-wave activity during subsequent sleep. J Neurosci 2008;28:7911-8.
  16. Moisello C, Bove M, Huber R, Abbruzzese G, Battaglia F, Tononi G, Ghilardi MF. Short-term limb immobilization affects motor performance. J Mot Behav 2008;40:165-76.
  17. Tononi G, Koch C. The neural correlates of consciousness: an update. Ann N Y Acad Sci 2008;1124:239-61.
  18. Vyazovskiy VV, Cirelli C, Pfister-Genskow M, Faraguna U, Tononi G. Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep. Nat Neurosci 2008;11:200-8.

Clare M. Waterman-Storer

  1. Gupton, S.L and C.M. Waterman-Storer. (2006) Spatiotemporal feedback between actomyosin and substrate adhesion dynamics optimizes rapid cell migration. Cell 125:1361-1374.
  2. Prigozhina N.P. and C.M. Waterman-Storer. (2006) Decreased polarity and increased random motility in PtK1 epithelial cells correlates with inhibition of endosomal recycling. J. Cell Sci. 119:3571-3582.
  3. Gupton SL, Eisenmann K, Alberts AS, Waterman-Storer CM. mDia2 regulates actin and focal adhesion dynamics and organization in the lamella for efficient epithelial cell migration. J Cell Sci 2007;120:3475-87. http://jcs.biologists.org/cgi/content/full/120/19/3475
  4. Hu, K., L. JL, K. Applegate, G. Danuser and C.M. Waterman-Storer. (2007) Transmission of actin motion within focal adhesions. Science 315:111-115.
  5. Sabass B, Gardel ML, Waterman CM, Schwarz US. High resolution traction force microscopy based on experimental and computational advances. Biophys J 2008;94:207-20.

Nathan D. Wolfe

  1. Kalish ML, Wolfe ND, Ndongmo C, Djoko C, Robbins KE, McNicholl J, Aidoo M, Fonjungp P, Alemnji G, Mpoudi-Ngole E, Zeh C, Folks TM, Burke DS. Central African hunters exposed to SIV. Emerg Infect Dis 2005 11:1928-30. http://www.cdc.gov/ncidod/EID/vol11no12/05-0394.htm
  2. Wolfe ND, Daszak P, Kilpatrick AM, Burke DS. Bushmeat hunting, deforestation, and predicting zoonotic emergence. Emerg Infect Dis 2005 11:1822-7. http://www.cdc.gov/ncidod/eid/vol11no12/04-0789.htm
  3. Wolfe ND, W Heneine, JK Carr, AD Barcia, V Shanmugam, U Tamoufe, JN Torimiro, AT Prosser, M LeBreton E Mpoudi-Ngole, FE McCutchan, DL Birx, TM Folks, DS Burke, WM Switzer (2005) Emergence of unique primate T-lymphotropic viruses among central African bushmeat hunters. Proc Natl Acad Sci USA. 102(22):7994-9. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=15911757
  4. Cummings AT, WJ Moss, K Long, TJ Muluh, B Kollo, E Nomo, ND Wolfe, DS Burke (2006) Improved measles surveillance in Cameroon reveals two major dynamic patterns of incidence. International Journal of Infectious Disease 10: 148-55
  5. Gupta SB, CT Mast, ND Wolfe, V Novitsky, SA Dubey, EG Kallas, M Schechter, B Mbewe, E Vardas, P Pitisuttihum, D Burke, D Freed, R Mogg, PM Coplan, JH Condra, RS Long, K Anderson, DR Casimiro, JW Shiver, WL Straus (2006) Cross-Clade Reactivity of Anti-HIV-1 Specific T-Cell Responses in HIV-1 Infected Individuals From Botswana and Cameroon. JAIDS 42:135-139
  6. Kuniholm MH, ND Wolfe, CYH Huang, E Mpoudi-Ngole, DS Burke, DJ Gubler (2006) Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults. American Journal of Tropical Medicine and Hygiene 74:1078-1083
  7. LeBreton M, AT Prosser, U Tamoufe, W Sateren, E Mpoudi-Ngole, DS Burke, ND Wolfe (2006) Patterns of hunting and perceptions of disease risk among central African communities. Animal Conservation
  8. LeBreton M, Umlauf S, Djoko C, Daszak P, Burke DS, Nwenkam PY, Wolfe ND. Rift valley fever in goats in southern Cameroon. Emerg Infect Dis 2006 12:702-3. http://www.cdc.gov/ncidod/Eid/vol12no04/05-1428.htm
  9. Leendertz FH, F Lankester, C Neel, O Drori, J Dupain, S Speede, P Reed, ND Wolfe, S Loul, E Mpoudi-Ngole, M Peeters, C Boesch, G Pauli, H Ellerbrok, E Leroy (2006) Anthrax joins Ebola in threatening central African great apes. American Journal of Primatology
  10. Murphy HW, M Miller, J Ramer, D Travis, R Barbiers, ND Wolfe, WM Switzer (2006) Implications of simian retroviruses for captive primate population management and the occupational safety of primate handlers. Journal of Zoo and Wildlife Management 37:219-33
  11. Ockenhouse CF, WC Hu, KE Huster, JF Cummings, A Stewart, DG Heppner, AE Jedlicka, AA Scott, ND Wolfe, M Vahey, DS Burke (2006) Common and Divergent Immune Response Signaling Pathways Discovered from Peripheral Blood Mononuclear Cell Gene Expression in Pre-symptomatic and Clinically Apparent Malaria. Infection and Immunity 74:5561-73 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16988231
  12. Steiper ME, ND Wolfe, WB Karesh, AM Kilbourn, EJ Bosi, M Ruvolo (2006) The phylogenetic and evolutionary history of a novel alpha-globin–type gene in orangutans (Pongo pygmaeus). Infect Genet Evol 6:277-286 Switzer, WM, I Hewlett, L Aaron, ND Wolfe, DS Burke, TM Folks, W Heneine (2006) Serological testing for HTLV-3 and HTLV-4. Transfusion
  13. Switzer WM, S Qari, ND Wolfe, DS Burke, TM Folks, W Heneine (2006) Ancient origin and molecular features of the novel Human T-Lymphotropic Virus Type 3 revealed by complete genome analysis. Journal of Virology http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16840323
  14. Torimiro JN, Carr JK, Wolfe ND, Karacki P, Martin MP, Gao X, Tamoufe U, Mpoudi-Ngole E, McCutchan FE, Birx DL, Burke DS, Carrington M. HLA class I diversity among rural rainforest inhabitants in Cameroon: Identification of A*2612-6*4407 haplotype. Tissue Antigens 2006 67:30-7.
  15. LeBreton M, Yang O, Tamoufe U, Mpoudi-Ngole E, Torimiro JN, Djoko CF, Carr JK, Tassy Prosser A, Rimoin AW, Birx DL, Burke DS, Wolfe ND. Exposure to wild primates among HIV-infected persons. Emerg Infect Dis 2007;13:1579-82.
  16. Rimoin AW, Kisalu N, Kebela-Ilunga B, Mukaba T, Wright LL, Formenty P, Wolfe ND, Shongo RL, Tshioko F, Okitolonda E, Muyembe JJ, Ryder RW, Meyer H (2007) Endemic Human Monkeypox, Democratic Republic of Congo, 2001-2004. Emerg Infect Dis 13:934-937.
  17. Torimiro JN, Wolfe ND, Thomas A, Martin MP, Mpoudi-Ngole E, Tamoufe U, Birx DL, Carrington M, Burke DS, Carr JK. Frequency of CCR5 variants among rural populations with low HIV-1 prevalence in Cameroon. AIDS 2007;21:527-8.
  18. Wolfe ND, C Panosian Dunavan, J Diamond (2007) Origins of major human infectious diseases. Nature 447:279- 283.
  19. Goldberg TL, Chapman CA, Cameron K, Saj T, Karesh WB, Wolfe ND, Wong SW, Dubois ME, Slifka MK. Serologic evidence for novel poxvirus in endangered red Colobus monkeys, Western Uganda. Emerg Infect Dis 2008;14:801-3.

Junying Yuan

  1. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 2005 307:935-9.
  2. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005 1:112-9.
  3. Lipinski MM, Yuan J. A cellular response to an internal energy crisis. Cell 2005 123:3-5.
  4. Boyce M, Yuan J. Cellular response to endoplasmic reticulum stress: A matter of life or death. Cell Death Differ 2006 13:363-73.
  5. Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, Macdonald

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2006 PIONEER AWARD RECIPIENTS

Kwabena A. Boahen

  1. J V Arthur and K Boahen, “Silicon Neurons that Inhibit to Synchronize”, IEEE International Symposium on Circuits and Systems, IEEE Press, pp 4807-4810, 2006.
  2. Boahen K. Neurogrid: emulating a million neurons in the cortex. Conf Proc IEEE Eng Med Biol Soc 2006;Suppl:6702.
  3. K M Hynna and K Boahen, “Neuronal Ion-Channel Dynamics in Silicon”, IEEE International Symposium on Circuits and Systems, IEEE Press, pp 3614-3617, 2006.
  4. J Lin, P Merolla, J Arthur and K Boahen, “Programmable Connections in Neuromorphic Grids”, 49th IEEE Midwest Symposium on Circuits and Systems, IEEE Press, 2006.
  5. P A Merolla and K Boahen, “Dynamic Computation in a Recurrent Network of Heterogeneous Silicon Neurons”, IEEE International Symposium on Circuits and Systems, IEEE Press, pp 4539-4542, 2006.
  6. Arthur JV, Boahen KA. Synchrony in silicon: the gamma rhythm. IEEE Trans Neural Netw 2007;18:1815-25.
  7. K M Hynna and K Boahen, “Silicon Neurons that Burst when Primed”, IEEE International Symposium on Circuits and Systems, May 2007.
  8. Hynna KM, Boahen K. Thermodynamically equivalent silicon models of voltage-dependent ion channels. Neural Comput 2007;19:327-50.
  9. Merolla PA, Arthur JV, Shi BE, Boahen KA. Expandable Networks for Neuromorphic Chips. In: IEEE JNL, Circuits and Systems I: Regular Papers, IEEE Transactions on; 2007:300-11.
  10. Silver R, Boahen K, Grillner S, Kopell N, Olsen KL. Neurotech for neuroscience: unifying concepts, organizing principles, and emerging tools. J Neurosci 2007;27:11807-19.
  11. Zaghloul KA, Manookin MB, Borghuis BG, Boahen K, Demb JB. Functional circuitry for peripheral suppression in Mammalian Y-type retinal ganglion cells. J Neurophysiol 2007;97:4327-40.

Arup K. Chakraborty

  1. Artyomov MN, Das J, Kardar M, Chakraborty AK. Purely stochastic binary decisions in cell signaling models without underlying deterministic bistabilities. Proc Natl Acad Sci U S A 2007;104:18958-63. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18025473
  2. Locasale JW, Chakraborty AK. Regulation of signal duration and the statistical dynamics of kinase activation by scaffold proteins. PLoS Comput Biol 2008;4:e1000099. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18584022 
  3. Locasale JW, Shaw AS, Chakraborty AK. Scaffold proteins confer diverse regulatory properties to protein kinase cascades. Proc Natl Acad Sci U S A 2007;104:13307-12. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17686969

Lila M. Gierasch

  1. Ignatova Z and Gierasch LM (2007) Effects of osmolytes on protein folding and aggregation in cells. Methods Enzymol. 428:355-372.
  2. Ignatova Z, Krishnan B, Bombardier JP, Marcelino AM, Hong J, Gierasch LM. (2007) From the test tube to the cell: exploring the folding and aggregation of a β-clam protein. Biopolymers 88:157-63.
  3. Ignatova Z, Thakur AK, Wetzel R, Gierasch LM. In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence. J Biol Chem 2007;282:36736-43. http://www.jbc.org/cgi/content/full/282/50/36736
  4. Krishnan B, Szymanska A, Gierasch LM. (2007) Site-specific fluorescent labeling of polyhistidine sequences using a metal-chelating cysteine. Chem. Biol. Drug Des. 69:31-40.
  5. Gierasch LM, Deber CM, Brodsky B. Celebrating the scientific legacy of Elkan R. Blout. Biopolymers 2008;89:323.

Rebecca W. Heald

  1. Brown KS, Blower MD, Maresca TJ, Grammer TC, Harland RM, Heald R. Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle. J Cell Biol 2007;176:765-70. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17339377

Cheng Chi Lee

  1. Lee CC. Constant darkness is a mammalian biological signal. Cold Spring Harb Symp Quant Biol 2007;72:287-91.

Evgeny A. Nudler

  1. Gusarov I, Starodubtseva M, Wang ZQ, McQuade L, Lippard SJ, Stuehr DJ, Nudler E. Bacterial nitric-oxide synthases operate without a dedicated redox partner. J Biol Chem 2008;283:13140.
  2. Shatalin K, Gusarov I, Avetissova E, Shatalina Y, McQuade LE, Lippard SJ, Nudler E. Bacillus anthracis-derived nitric oxide is essential for pathogen virulence and survival in macrophages. Proc Natl Acad Sci U S A 2008;105:1009-13. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18215992

Gary J. Pielak

  1. Bryant JE, Lecomte JT, Lee AL, Young GB, Pielak GJ. Protein dynamics in living cells. Biochemistry 2005;44:9275-9.
  2. Winzor DJ, Patel CN, Pielak GJ. Reconsideration of sedimentation equilibrium distributions reflecting the effects of small inert cosolutes on the dimerization of alpha-chymotrypsin. Biophys Chem 2007;130:89-92.
  3. Charlton LM, Barnes CO, Li C, Orans J, Young GB, Pielak GJ. Residue-level interrogation of macromolecular crowding effects on protein stability. J Am Chem Soc 2008;130:6826-30. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18459780
  4. Li C, Charlton LM, Lakkavaram A, Seagle C, Wang G, Young GB, Macdonald JM, Pielak GJ. Differential dynamical effects of macromolecular crowding on an intrinsically disordered protein and a globular protein: implications for in-cell NMR spectroscopy. J Am Chem Soc 2008;130:6310-1. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18419123

David A. Relman

  1. Relman DA, Versalovic J. How bacterial communities expand functional repertoires. PLoS Biology 2006; 4(12): e430. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17238278
  2. Dethlefsen L, McFall-Ngai M, Relman DA. An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature 2007;449:811-8.
  3. Dethlefsen L, Relman DA. The importance of individuals and scale: moving towards single cell microbiology. Environ Microbiol 2007;9:8-10.
  4. Marcy Y, Ouverney C, Bik E, Loesekann T, Martin H, Szeto E, Platt D, Hugenholtz P, Relman DA, Quake SR. Dissecting biological dark matter with single cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth. Proc Natl Acad Sci (USA) 2007; 104(29):11889-94.
  5. Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO. Development of the human infant intestinal microbiota. PLoS Biology 2007; 5(7): e177 http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17594176
  6. Behrens S, Losekann T, Pett-Ridge J, Weber PK, Ng WO, Stevenson BS, Hutcheon ID, Relman DA, Spormann AM. Linking microbial phylogeny to metabolic activity at the single-cell level by using enhanced element labeling-catalyzed reporter deposition fluorescence in situ hybridization (EL-FISH) and NanoSIMS. Appl Environ Microbiol 2008;74:3143-50.

James L. Sherley

  1. Sherley JL. All good cells come from cells. Nat Cell Biol 2008;10:248.
  2. Sherley JL. Commentary: Facing up to the feasibility of ANT-OAR. Stem Cell Rev 2007;3:66-7.
  3. Taghizadeh RR, Sherley JL. CFP and YFP, but not GFP, provide stable fluorescent marking of rat hepatic adult stem cells. J Biomed Biotechnol 2008;2008:453590. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18401450

Younan Xia

  1. Chen, J.; McLellan, J. M.; Siekkinen, A.; Xiong, Y.; Li, Z.-Y.; Xia, Y. “Facile Synthesis of Gold-Silver Nanocages with Controllable Pores on the Surface” Journal of the American Chemical Society 2006, 128, 14776-14777.
  2. Camargo PH, Xiong Y, Ji L, Zuo JM, Xia Y. Facile synthesis of tadpole-like nanostructures consisting of Au heads and Pd tails. J Am Chem Soc 2007;129:15452-3.
  3. Chen J, Wang D, Xi J, Au L, Siekkinen A, Warsen A, Li ZY, Zhang H, Xia Y, Li X. Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells. Nano Lett 2007;7:1318-22. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17430005
  4. Hu M, Chen J, Marquez M, Xia Y. Correlated Rayleigh scattering spectroscopy and scanning electron microscopy studies of Au-Ag Bimetallic nanoboxes and nanocages. Journal of Physical Chemistry 2007;111:12558-65.
  5. Lu X, Au L, McLellan J, Li ZY, Marquez M, Xia Y. Fabrication of cubic nanocages and nanoframes by dealloying Au/Ag alloy nanoboxes with an aqueous etchant based on Fe(NO3)3 or NH4OH. Nano Lett 2007;7:1764-9. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17489641
  6. Lu, X.; Tuan, H.-Y.; Chen, J.; Li, Z.-Y.; Korgel, B.; Xia, Y. “Mechanistic Studies on the Galvanic Replacement Reaction between Multiply Twinned Particles of Ag and HAuCl4 in an Organic Medium” Journal of the American Chemical Society 2007, 129, 1733-1742.
  7. Lu X, Tuan HY, Korgel BA, Xia Y. Facile synthesis of gold nanoparticles with narrow size distribution by using AuCl or AuBr as the precursor. Chemistry 2008;14:1584-91. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18058964
  8. Petrova, H.; Lin, C.-H.; Hu, M.; Chen, J.; Siekkinen, A. R. Xia, Y.; Sader, J. E.; Hartland, G. V. “Vibrational response of Au-Ag Nanoboxes and Nanocages to Ultrafast Laser-Induced Heating” Nano Letters 2007, 7, 1059-1063.
  9. Skrabalak SE, Au L, Lu X, Li X, Xia Y. Gold nanocages for cancer detection and treatment. Nanomed 2007;2:657-68.
  10. Yang X, Skrabalak SE, Li ZY, Xia Y, Wang LV. Photoacoustic tomography of a rat cerebral cortex in vivo with au nanocages as an optical contrast agent. Nano Lett 2007;7:3798-802.
  11. Hu M, Novo C, Funston A, Wang H, Petrova H, Zou S, Mulvaney P, Xia Y, Hartland GV. Dark-field microspcopy stydies of single metal nanoparticles: Understanding the factors that influend the linewidth of the localized surface plasmon resonance. Journal of Materials Chemistry 2008;18:1949-60.
  12. Kim MH, Lu X, Wiley B, Lee EP, Xia Y. Morphological evolution of single-crystal Ag nanospheres during the galvanic replacement reaction wtih HAuCL4. Journal of Physical Chemistry 2008;112:7872-6.

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2007 PIONEER AWARD RECIPIENTS

Lisa Feldman Barrett

  1. Kober H, Barrett LF, Joseph J, Bliss-Moreau E, Lindquist K, Wager TD. Functional grouping and cortical-subcortical interactions in emotion: a meta-analysis of neuroimaging studies. Neuroimage 2008;42:998-1031.
  2. Wager TD, Barrett LF, Bliss-Moreau E, Lindquist K, Duncan S, Kober H, Joseph J, Davidson M, Mize J. The neuroimaging of emotion. In: M. Lewis JMH-J, and L.F. Barrett, ed. The handbook of emotion. 3rd ed. New York: Guilford; 2008:249-71.
  3. Wright CI, Negreira A, Gold AL, Britton JC, Williams D, Barrett LF. Neural correlates of novelty and face-age effects in young and elderly adults. Neuroimage 2008;42:956-68.

Emery N. Brown

  1. Brown KS, Blower MD, Maresca TJ, Grammer TC, Harland RM, Heald R. Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle. J Cell Biol 2007;176:765-70. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17339377
  2. Palmer C, Bik EM, Digiulio DB, Relman DA, Brown PO. Development of the Human Infant Intestinal Microbiota. PLoS Biol 2007;5:e177. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=17594176
  3. Ulmann PA, Brown AM, Ovchinnikov MV, Mirkin CA, DiPasquale AG, Rheingold AL. Spontaneous formation of heteroligated PtII complexes with chelating hemilabile ligands. Chemistry 2007;13:4529-34.
  4. Mollins A, Hmlinen MS, Brown EN. Functional localization in EEG+MEG using EM estimation on a state-space model with spatial and time smoothness constraint. Brain Mapping 2008.
  5. Molins A, Stufflebeam SM, Brown EN, Hamalainen MS. Quantification of the benefit from integrating MEG and EEG data in minimum l2-norm estimation. Neuroimage 2008;42:1069-77.
  6. Mollins A, Stufflebeam SM, Brown EN. Integration of MEG and EEG data in minimun L2 norm estimation. Human Brain Mapping 2008.
  7. Napadow V, Dhond R, Conti G, Makris N, Brown EN, Barbieri R. Brain correlates of autonomic modulation: combining heart rate variability with fMRI. Neuroimage 2008;42:169-77.

Thomas R. Clandinin

  1. Velez MM, Clandinin TR. Neural circuitry: seeing the parts that make the picture. Curr Biol 2008;18:R378-80.

James J. Collins

  1. Ellis T, Wang X, Collins JJ. Gene regulation: hacking the network on a sugar high. Mol Cell 2008;30:1-2.
  2. Kohanski MA, Collins JJ. Rewiring bacteria, two components at a time. Cell 2008;133:947-8.

Margaret Gardel

  1. Sabass B, Gardel ML, Waterman CM, Schwarz US. High resolution traction force microscopy based on experimental and computational advances. Biophys J 2008;94:207-20.

Marshall S. Horwitz

  1. Salipante SJ, Thompson JM, Horwitz MS. Phylogenetic fate mapping: theoretical and experimental studies applied to the development of mouse fibroblasts. Genetics 2008;178:967-77. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18245843

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This page last reviewed: September 8, 2008