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CNGRC peptide-TNF alpha conjugate A cytokine-peptide conjugate composed of the cytokine tumor necrosis factor alpha (TNF-alpha) chemically linked to the peptide CNGRC. The peptide moiety CNGRC, a ligand for the membrane-bound metalloprotease CD13, binds to endothelial cells of the angiogenic vasculature that express CD13 (also known as aminopeptidase N); subsequently, the TNF-alpha moiety induces apoptosis in endothelial cells expressing CD13, thereby inhibiting tumor-associated angiogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090115060002im_/http://www.cancer.gov/images/spacer.gif) | CNGRC peptide-tumor necrosis factor alpha conjugate tumor vasculature-targeted tumor necrosis factor alpha | | ![](https://webarchive.library.unt.edu/eot2008/20090115060002im_/http://www.cancer.gov/images/spacer.gif) | Abbreviations: | ![](https://webarchive.library.unt.edu/eot2008/20090115060002im_/http://www.cancer.gov/images/spacer.gif) | NGR-hTNF NGR-TNF | | ![](https://webarchive.library.unt.edu/eot2008/20090115060002im_/http://www.cancer.gov/images/spacer.gif) |
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