| | This journal provides immediate access to some articles. Introduction Searching for an alien haven in the heavens Bridget C. Coughlin Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 796. PMCID: PMC33369 Commentaries Order emerging from chaos in human evolutionary genetics Alan R. Rogers Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 779–780. PMCID: PMC33363 DNA replication blockade impairs p53-transactivation Rishu Takimoto and Wafik S. El-Deiry Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 781–783. PMCID: PMC33364 Plant mitogen-activated protein kinase cascades: Negative
regulatory roles turn out positive Andrew F. Bent Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 784–786. PMCID: PMC33365 PDZ domains: More than just a glue Ilya Bezprozvanny and Anton Maximov Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 787–789. PMCID: PMC33366 Polycystic kidney disease: In danger of being X-rated? Jared J. Grantham and James P. Calvet Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 790–792. PMCID: PMC33367 How might cannabinoids influence sexual behavior? Nephi Stella Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 793–795. PMCID: PMC33368 Perspective Special Feature: State-of-the-art instruments for detecting extraterrestrial life Jeffrey L. Bada Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 797–800. PMCID: PMC33370 Special Feature: Possible ecosystems and the search for life on Europa Christopher F. Chyba and Cynthia B. Phillips Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 801–804. PMCID: PMC33371 Special Feature: The universal nature of biochemistry Norman R. Pace Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 805–808. PMCID: PMC33372 Special Features Searching for an alien haven in the heavens Bridget C. Coughlin Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 796. PMCID: PMC33369 Special Feature: State-of-the-art instruments for detecting extraterrestrial life Jeffrey L. Bada Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 797–800. PMCID: PMC33370 Special Feature: Possible ecosystems and the search for life on Europa Christopher F. Chyba and Cynthia B. Phillips Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 801–804. PMCID: PMC33371 Special Feature: The universal nature of biochemistry Norman R. Pace Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 805–808. PMCID: PMC33372 Special Feature: The occurrence of Jovian planets and the habitability of
planetary systems Jonathan I. Lunine Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 809–814. PMCID: PMC14664 Special Feature: Self-assembling amphiphilic molecules: Synthesis in simulated
interstellar/precometary ices Jason P. Dworkin, David W. Deamer, Scott A. Sandford, and Louis J. Allamandola Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 815–819. PMCID: PMC14665 Special Feature: From the Cover: Differential adsorption of nucleic acid bases: Relevance to the
origin of life Stephen J. Sowerby, Corey A. Cohn, Wolfgang M. Heckl, and Nils G. Holm Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 820–822. PMCID: PMC14666 Special Feature: In situ laser-Raman imagery of Precambrian
microscopic fossils Anatoliy B. Kudryavtsev, J. William Schopf, David G. Agresti, and Thomas J. Wdowiak Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 823–826. PMCID: PMC14667 Special Feature: Pre-Global Surveyor evidence for Martian ground water Thomas M. Donahue Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 827–830. PMCID: PMC14668 Physical Sciences Applied Mathematics Evolution of treatment effects over time: Empirical insight from
recursive cumulative metaanalyses John P. A. Ioannidis and Joseph Lau Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 831–836. Published online 2001 January 23. PMCID: PMC14669 A stochastic model for the self-similar heterogeneity of regional
organ blood flow Wayne S. Kendal Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 837–841. Published online 2001 January 23. PMCID: PMC14670 Astronomy Special Feature: The occurrence of Jovian planets and the habitability of
planetary systems Jonathan I. Lunine Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 809–814. PMCID: PMC14664 Chemistry Special Feature: Self-assembling amphiphilic molecules: Synthesis in simulated
interstellar/precometary ices Jason P. Dworkin, David W. Deamer, Scott A. Sandford, and Louis J. Allamandola Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 815–819. PMCID: PMC14665 Special Feature: From the Cover: Differential adsorption of nucleic acid bases: Relevance to the
origin of life Stephen J. Sowerby, Corey A. Cohn, Wolfgang M. Heckl, and Nils G. Holm Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 820–822. PMCID: PMC14666 AB-polymer networks based on oligo( -caprolactone) segments
showing shape-memory properties Andreas Lendlein, Annette M. Schmidt, and Robert Langer Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 842–847. Published online 2001 January 23. PMCID: PMC14671 Convex Arrhenius plots and their interpretation Donald G. Truhlar and Amnon Kohen Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 848–851. PMCID: PMC14672 Monolayers of derivatized poly(l-lysine)-grafted
poly(ethylene glycol) on metal oxides as a class of
biomolecular interfaces L. A. Ruiz-Taylor, T. L. Martin, F. G. Zaugg, K. Witte, P. Indermuhle, S. Nock, and P. Wagner Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 852–857. PMCID: PMC14673 Geology Special Feature: In situ laser-Raman imagery of Precambrian
microscopic fossils Anatoliy B. Kudryavtsev, J. William Schopf, David G. Agresti, and Thomas J. Wdowiak Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 823–826. PMCID: PMC14667 Geophysics Special Feature: Pre-Global Surveyor evidence for Martian ground water Thomas M. Donahue Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 827–830. PMCID: PMC14668 Biological Sciences Anthropology Distinctive genetic signatures in the Libyan Jews Noah A. Rosenberg, Eilon Woolf, Jonathan K. Pritchard, Tamar Schaap, Dov Gefel, Isaac Shpirer, Uri Lavi, Batsheva Bonné-Tamir, Jossi Hillel, and Marcus W. Feldman Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 858–863. PMCID: PMC14674 A highly variable segment of human subterminal 16p reveals a
history of population growth for modern humans outside Africa Santos Alonso and John A. L. Armour Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 864–869. Published online 2000 December 19. PMCID: PMC14675 Biochemistry Convex Arrhenius plots and their interpretation Donald G. Truhlar and Amnon Kohen Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 848–851. PMCID: PMC14672 De novo design and characterization of an apolar
helical hairpin peptide at atomic resolution: Compaction mediated by
weak interactions Udupi A. Ramagopal, Suryanarayanarao Ramakumar, Dinkar Sahal, and Virander S. Chauhan Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 870–874. PMCID: PMC14676 Overexpression of the inositol phosphatase SopB in human 293
cells stimulates cellular chloride influx and inhibits nuclear mRNA
export Yucheng Feng, Susan R. Wente, and Philip W. Majerus Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 875–879. Published online 2001 January 16. PMCID: PMC14677 Polar side chains drive the association of model
transmembrane peptides Holly Gratkowski, James D. Lear, and William F. DeGrado Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 880–885. PMCID: PMC14678 Ribosome shunt is essential for infectivity of cauliflower
mosaic virus Mikhail M. Pooggin, Johannes Fütterer, Konstantin G. Skryabin, and Thomas Hohn Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 886–891. PMCID: PMC14679 Bacterial RNA polymerase subunit ω and eukaryotic RNA
polymerase subunit RPB6 are sequence, structural, and functional
homologs and promote RNA polymerase assembly Leonid Minakhin, Sechal Bhagat, Adrian Brunning, Elizabeth A. Campbell, Seth A. Darst, Richard H. Ebright, and Konstantin Severinov Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 892–897. PMCID: PMC14680 Rotation of the c subunit oligomer in fully functional
F1Fo ATP synthase Satoshi P. Tsunoda, Robert Aggeler, Masasuke Yoshida, and Roderick A. Capaldi Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 898–902. Published online 2001 January 23. PMCID: PMC14681 Directed evolution of ampicillin-resistant activity from a
functionally unrelated DNA fragment: A laboratory model of
molecular evolution Takato Yano and Hiroyuki Kagamiyama Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 903–907. Published online 2001 January 23. PMCID: PMC14682 The critical role of DNA in the equilibrium between OmpR and
phosphorylated OmpR mediated by EnvZ in
Escherichia coli Ling Qin, Takeshi Yoshida, and Masayori Inouye Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 908–913. Published online 2001 January 23. PMCID: PMC14683 Subunit interactions influence the biochemical and biological
properties of Hsp104 Eric C. Schirmer, Danielle M. Ware, Christine Queitsch, Anthony S. Kowal, and Susan L. Lindquist Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 914–919. Published online 2001 January 23. PMCID: PMC14684 Protein–protein interactions with subunits of human
nuclear RNase P Taijiao Jiang and Sidney Altman Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 920–925. Published online 2001 January 16. PMCID: PMC14685 Characterization of a quinone reductase activity for the
mitomycin C binding protein (MRD): Functional switching from a
drug-activating enzyme to a drug-binding protein Min He, Paul J. Sheldon, and David H. Sherman Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 926–931. Published online 2001 January 23. PMCID: PMC14686 An unusual isopentenyl diphosphate isomerase found in the
mevalonate pathway gene cluster from Streptomyces sp.
strain CL190 Kazuhide Kaneda, Tomohisa Kuzuyama, Motoki Takagi, Yoichi Hayakawa, and Haruo Seto Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 932–937. Published online 2001 January 23. PMCID: PMC14687 Caspase-2 pre-mRNA alternative splicing: Identification of an
intronic element containing a decoy 3′ acceptor site Jocelyn Côté, Sophie Dupuis, Zhi-Hong Jiang, and Jane Y. Wu Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 938–943. Published online 2001 January 23. PMCID: PMC14688 Molecular clocks Noah E. Robinson and Arthur B. Robinson Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 944–949. PMCID: PMC14689 Biophysics Selectin receptor–ligand bonds: Formation limited by shear
rate and dissociation governed by the Bell model Shuqi Chen and Timothy A. Springer Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 950–955. PMCID: PMC14690 Changes in protein conformational mobility upon activation of
extracellular regulated protein kinase-2 as detected by
hydrogen exchange Andrew N. Hoofnagle, Katheryn A. Resing, Elizabeth J. Goldsmith, and Natalie G. Ahn Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 956–961. PMCID: PMC14691 Primary reactions of sensory rhodopsins I. Lutz, A. Sieg, A. A. Wegener, M. Engelhard, I. Boche, M. Otsuka, D. Oesterhelt, J. Wachtveitl, and W. Zinth Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 962–967. Published online 2001 January 16. PMCID: PMC14692 Dynamics of site juxtaposition in supercoiled DNA Jing Huang, Tamar Schlick, and Alexander Vologodskii Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 968–973. PMCID: PMC14693 Cell Biology Regulation of Smad degradation and activity by Smurf2, an E3
ubiquitin ligase Ying Zhang, Chenbei Chang, Daniel J. Gehling, Ali Hemmati-Brivanlou, and Rik Derynck Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 974–979. PMCID: PMC14694 The MinE ring required for proper placement of the division site
is a mobile structure that changes its cellular location during the
Escherichia coli division cycle Xiaoli Fu, Yu-Ling Shih, Yan Zhang, and Lawrence I. Rothfield Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 980–985. Published online 2001 January 23. PMCID: PMC14695 Mouse model of congenital polycythemia: Homologous replacement of
murine gene by mutant human erythropoietin receptor gene Vladimir Divoky, Zhiyong Liu, Thomas M. Ryan, Jaroslav F. Prchal, Tim M. Townes, and Josef T. Prchal Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 986–991. PMCID: PMC14696 INAUGURAL ARTICLE by a Recently Elected Academy Member: Defective repression of c- myc in breast cancer
cells: A loss at the core of the transforming growth factor β
growth arrest program Chang-Rung Chen, Yibin Kang, and Joan Massagué Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 992–999. PMCID: PMC14697 Aquaporins in Saccharomyces: Characterization of a
second functional water channel protein Jennifer M. Carbrey, Mélanie Bonhivers, Jef D. Boeke, and Peter Agre Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1000–1005. PMCID: PMC14698 The midblastula transition in Xenopus embryos
activates multiple pathways to prevent apoptosis in
response to DNA damage Carla V. Finkielstein, Andrea L. Lewellyn, and James L. Maller Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1006–1011. PMCID: PMC14699 Proteins associated with the promyelocytic leukemia gene product
(PML)-containing nuclear body move to the nucleolus upon inhibition
of proteasome-dependent protein degradation Karin Mattsson, Katja Pokrovskaja, Csaba Kiss, George Klein, and Laszlo Szekely Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1012–1017. Published online 2001 January 23. PMCID: PMC14700 Characterization of Rny1, the Saccharomyces
cerevisiae member of the T2 RNase family of
RNases: Unexpected functions for ancient enzymes? Gustavo C. MacIntosh, Pauline A. Bariola, Ed Newbigin, and Pamela J. Green Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1018–1023. PMCID: PMC14701 Interaction of endostatin with integrins implicated
in angiogenesis Marko Rehn, Tanja Veikkola, Eola Kukk-Valdre, Hitoshi Nakamura, Maritta Ilmonen, Christian R. Lombardo, Taina Pihlajaniemi, Kari Alitalo, and Kristiina Vuori Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1024–1029. Published online 2001 January 23. PMCID: PMC14702 REF proteins mediate the export of spliced and unspliced mRNAs
from the nucleus João P. Rodrigues, Michaela Rode, David Gatfield, Benjamin J. Blencowe, Maria Carmo-Fonseca, and Elisa Izaurralde Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1030–1035. Published online 2001 January 23. PMCID: PMC14703 From the Cover: p53 accumulates but is functionally impaired when DNA synthesis
is blocked Vanesa Gottifredi, Sheau-Yann Shieh, Yoichi Taya, and Carol Prives Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1036–1041. Published online 2001 January 23. PMCID: PMC14704 Integrin-mediated mechanotransduction requires its dynamic
interaction with specific extracellular matrix (ECM) ligands Shila Jalali, Miguel A. del Pozo, Kuang-Den Chen, Hui Miao, Yi-Shuan Li, Martin A. Schwartz, John Y.-J. Shyy, and Shu Chien Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1042–1046. Published online 2001 January 23. PMCID: PMC14705 Developmental Biology Cellular and molecular responses of the uterus to embryo
implantation can be elicited by locally applied growth factors Bibhash C. Paria, Wen-ge Ma, Jian Tan, Shefali Raja, Sonjoy K. Das, Sudhansu K. Dey, and Brigid L. M. Hogan Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1047–1052. PMCID: PMC14706 Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in
insect endoderm and the vertebrate enteric neurons Mounou Hahn and J. Michael Bishop Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1053–1058. Published online 2001 January 16. PMCID: PMC14707 Failure of ductus arteriosus closure and remodeling in neonatal
mice deficient in cyclooxygenase-1 and cyclooxygenase-2 Charles D. Loftin, Darshini B. Trivedi, Howard F. Tiano, James A. Clark, Christopher A. Lee, Jonathan A. Epstein, Scott G. Morham, Matthew D. Breyer, MyTrang Nguyen, Beau M. Hawkins, Jennifer L. Goulet, Oliver Smithies, Beverly H. Koller, and Robert Langenbach Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1059–1064. Published online 2001 January 23. PMCID: PMC14708 PDX:PBX complexes are required for normal proliferation of
pancreatic cells during development Sanjoy Dutta, Maureen Gannon, Bernard Peers, Chris Wright, Susan Bonner-Weir, and Marc Montminy Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1065–1070. Published online 2001 January 16. PMCID: PMC14709 Fertile and diploid nuclear transplants derived from embryonic
cells of a small laboratory fish, medaka
(Oryzias latipes) Yuko Wakamatsu, Bensheng Ju, Inna Pristyaznhyuk, Katsutoshi Niwa, Tatiana Ladygina, Masato Kinoshita, Kazuo Araki, and Kenjiro Ozato Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1071–1076. PMCID: PMC14710 Reprogramming of telomerase activity and rebuilding of telomere
length in cloned cattle Dean H. Betts, Vilceu Bordignon, Jonathan R. Hill, Quinton Winger, Mark E. Westhusin, Lawrence C. Smith, and W. Allan King Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1077–1082. Published online 2001 January 16. PMCID: PMC14711 Ecology Extrafloral nectar production of the ant-associated plant,
Macaranga tanarius, is an induced, indirect, defensive
response elicited by jasmonic acid Martin Heil, Thomas Koch, Andrea Hilpert, Brigitte Fiala, Wilhelm Boland, and K. Eduard Linsenmair Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1083–1088. Published online 2001 January 16. PMCID: PMC14712 To walk or to fly? How birds choose among foraging modes Luis M. Bautista, Joost Tinbergen, and Alejandro Kacelnik Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1089–1094. PMCID: PMC14713 Patterns of spread in biological invasions dominated by
long-distance jump dispersal: Insights from Argentine ants Andrew V. Suarez, David A. Holway, and Ted J. Case Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1095–1100. PMCID: PMC14714 Evolution An orphaned mammalian β-globin gene of ancient evolutionary
origin David Wheeler, Rory Hope, Steven J. B. Cooper, Gaynor Dolman, Graham C. Webb, Cynthia D. K. Bottema, Andrew A. Gooley, Morris Goodman, and Robert A. B. Holland Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1101–1106. PMCID: PMC14715 Environmental stress and mutational load in diploid strains of
the yeast Saccharomyces cerevisiae Krzysztof Szafraniec, Rhona H. Borts, and Ryszard Korona Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1107–1112. Published online 2001 January 16. PMCID: PMC14716 Fitness effects of advantageous mutations in evolving
Escherichia coli populations Marianne Imhof and Christian Schlötterer Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1113–1117. PMCID: PMC14717 Genetics A mouse model of multiple endocrine neoplasia, type 1, develops
multiple endocrine tumors Judy S. Crabtree, Peter C. Scacheri, Jerrold M. Ward, Lisa Garrett-Beal, Michael R. Emmert-Buck, Keith A. Edgemon, Dominique Lorang, Steven K. Libutti, Settara C. Chandrasekharappa, Stephen J. Marx, Allen M. Spiegel, and Francis S. Collins Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1118–1123. PMCID: PMC14718 Expression profiling reveals fundamental biological differences
in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics Kimmo Virtaneva, Fred A. Wright, Stephan M. Tanner, Bo Yuan, William J. Lemon, Michael A. Caligiuri, Clara D. Bloomfield, Albert de la Chapelle, and Ralf Krahe Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1124–1129. PMCID: PMC14719 Analysis of the blind Drosophila mutant
ninaB identifies the gene encoding the key enzyme for vitamin A formation in vivo Johannes von Lintig, Armin Dreher, Cornelia Kiefer, Mathias F. Wernet, and Klaus Vogt Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1130–1135. Published online 2001 January 16. PMCID: PMC14720 Similar regions of human chromosome 3 are eliminated from or
retained in human/human and human/mouse microcell hybrids
during tumor growth in severe combined immunodeficient (SCID)
mice Ying Yang, Maria Kost-Alimova, Sigurdur Ingvarsson, Qiu Qianhui, Hajnalka Kiss, Anna Szeles, Irina Kholodnyuk, Andrew Cuthbert, George Klein, and Stephan Imreh Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1136–1141. PMCID: PMC14721 Immunology Genetic remodeling of protein glycosylation in
vivo induces autoimmune disease Daniel Chui, Gayathri Sellakumar, Ryan S. Green, Mark Sutton-Smith, Tammie McQuistan, Kurt W. Marek, Howard R. Morris, Anne Dell, and Jamey D. Marth Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1142–1147. PMCID: PMC14722 The mechanism by which a peptide based on
complementarity-determining region-1 of a pathogenic anti-DNA auto-Ab
ameliorates experimental systemic lupus erythematosus Eran Eilat, Molly Dayan, Heidy Zinger, and Edna Mozes Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1148–1153. PMCID: PMC14723 Activated Cdc42/Rac reconstitutes Fc RI-mediated
Ca 2+ mobilization and degranulation in mutant RBL mast
cells Elizabeth Hong-Geller, David Holowka, Reuben P. Siraganian, Barbara Baird, and Richard A. Cerione Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1154–1159. PMCID: PMC14724 CD8+ T cells recognize an inclusion
membrane-associated protein from the vacuolar pathogen Chlamydia trachomatis Steven P. Fling, R. Alec Sutherland, Lisa N. Steele, Bruce Hess, Sarah E. F. D'Orazio, Jean-François Maisonneuve, Mary F. Lampe, Peter Probst, and Michael N. Starnbach Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1160–1165. PMCID: PMC14725 CD40-CD40L independent Ig gene hypermutation suggests a second B
cell diversification pathway in humans Sandra Weller, Ahmad Faili, Corinne Garcia, Moritz C. Braun, Françoise Le Deist, Geneviève de Saint Basile, Olivier Hermine, Alain Fischer, Claude-Agnès Reynaud, and Jean-Claude Weill Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1166–1170. PMCID: PMC14726 Medical Sciences Evolution of treatment effects over time: Empirical insight from
recursive cumulative metaanalyses John P. A. Ioannidis and Joseph Lau Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 831–836. Published online 2001 January 23. PMCID: PMC14669 A cross-link breaker has sustained effects on arterial and
ventricular properties in older rhesus monkeys Peter V. Vaitkevicius, Mark Lane, Harold Spurgeon, Donald K. Ingram, George S. Roth, John J. Egan, Sara Vasan, Dilip R. Wagle, Peter Ulrich, Michael Brines, Jean Paul Wuerth, Anthony Cerami, and Edward G. Lakatta Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1171–1175. PMCID: PMC14727 Analysis of gene expression profiles in normal and neoplastic
ovarian tissue samples identifies candidate molecular markers
of epithelial ovarian cancer John B. Welsh, Patrick P. Zarrinkar, Lisa M. Sapinoso, Suzanne G. Kern, Cynthia A. Behling, Bradley J. Monk, David J. Lockhart, Robert A. Burger, and Garret M. Hampton Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1176–1181. PMCID: PMC14728 From the Cover: Polycystin-2, the protein mutated in autosomal dominant
polycystic kidney disease (ADPKD), is a Ca2+-permeable
nonselective cation channel Silvia González-Perrett, Keetae Kim, Cristina Ibarra, Alicia E. Damiano, Elsa Zotta, Marisa Batelli, Peter C. Harris, Ignacio L. Reisin, M. Amin Arnaout, and Horacio F. Cantiello Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1182–1187. Published online 2000 December 26. PMCID: PMC14729 Regulation of p53 stability and p53-dependent apoptosis
by NADH quinone oxidoreductase 1 Gad Asher, Joseph Lotem, Batya Cohen, Leo Sachs, and Yosef Shaul Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1188–1193. Published online 2001 January 23. PMCID: PMC14730 Lack of type XV collagen causes a skeletal myopathy and
cardiovascular defects in mice Lauri Eklund, Jarkko Piuhola, Jyrki Komulainen, Raija Sormunen, Chalermporn Ongvarrasopone, Reinhard Fässler, Anu Muona, Mika Ilves, Heikki Ruskoaho, Timo E. S. Takala, and Taina Pihlajaniemi Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1194–1199. Published online 2001 January 23. PMCID: PMC14731 Polymer-based gene delivery with low cytotoxicity by a unique
balance of side-chain termini David Putnam, Christine A. Gentry, Daniel W. Pack, and Robert Langer Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1200–1205. Published online 2001 January 23. PMCID: PMC14732 Copper-64-diacetyl-bis(N4-methylthiosemicarbazone):
An agent for radiotherapy Jason S. Lewis, Richard Laforest, Thomas L. Buettner, Sheng-Kwei Song, Yasuhisa Fujibayashi, Judith M. Connett, and Michael J. Welch Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1206–1211. PMCID: PMC14733 Prolonging the half-life of human interferon-α2 in circulation:
Design, preparation, and analysis
of (2-sulfo-9-fluorenylmethoxycarbonyl)7- interferon-α2 Yoram Shechter, Liana Preciado-Patt, Gideon Schreiber, and Mati Fridkin Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1212–1217. PMCID: PMC14734 Complete switch from Mdm2 to human papillomavirus E6-mediated
degradation of p53 in cervical cancer cells Arnd Hengstermann, Laetitia K. Linares, Aaron Ciechanover, Noel J. Whitaker, and Martin Scheffner Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1218–1223. Published online 2001 January 23. PMCID: PMC14735 Microbiology An Epstein–Barr-related herpesvirus from marmoset lymphomas Young-Gyu Cho, Jan Ramer, Pierre Rivailler, Carol Quink, Richard L. Garber, David R. Beier, and Fred Wang Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1224–1229. PMCID: PMC14736 Neurobiology Odor-evoked calcium signals in dendrites of rat mitral cells Serge Charpak, Jerome Mertz, Emmanuel Beaurepaire, Laurent Moreaux, and Kerry Delaney Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1230–1234. Published online 2001 January 16. PMCID: PMC14737 Nodes of Ranvier form in association with ezrin-radixin-moesin
(ERM)-positive Schwann cell processes Carmen V. Melendez-Vasquez, Jose C. Rios, George Zanazzi, Stephen Lambert, Anthony Bretscher, and James L. Salzer Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1235–1240. PMCID: PMC14738 INAUGURAL ARTICLE by a Recently Elected Academy Member: Acetylcholine receptor channel structure in the resting, open,
and desensitized states probed with the
substituted-cysteine-accessibility method Gary G. Wilson and Arthur Karlin Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1241–1248. Published online 2001 January 16. PMCID: PMC14739 From the Cover: Progesterone receptor and dopamine receptors are required in
Δ9-tetrahydrocannabinol modulation of sexual
receptivity in female rats Shailaja K. Mani, Andrea Mitchell, and Bert W. O'Malley Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1249–1254. Published online 2001 January 23. PMCID: PMC14740 Dopamine-dependent synaptic plasticity in striatum during
in vivo development Ka-Choi Tang, Malcolm J. Low, David K. Grandy, and David M. Lovinger Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1255–1260. Published online 2001 January 16. PMCID: PMC14741 Contribution of cytoskeleton to the internalization of
AMPA receptors Qiang Zhou, Min-Yi Xiao, and Roger A. Nicoll Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1261–1266. Published online 2001 January 23. PMCID: PMC14742 Cholesterol binding at the cholesterol
recognition/ interaction amino acid consensus (CRAC) of the
peripheral-type benzodiazepine receptor and inhibition of
steroidogenesis by an HIV TAT-CRAC peptide Hua Li, Zhi-xing Yao, Babett Degenhardt, Gary Teper, and Vassilios Papadopoulos Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1267–1272. Published online 2001 January 23. PMCID: PMC14743 Control of eye movements and spatial attention Tirin Moore and Mazyar Fallah Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1273–1276. Published online 2001 January 16. PMCID: PMC14744 Brain serotonin dysfunction accounts for aggression in male mice
lacking neuronal nitric oxide synthase Silvana Chiavegatto, Valina L. Dawson, Laura A. Mamounas, Vassilis E. Koliatsos, Ted M. Dawson, and Randy J. Nelson Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1277–1281. Published online 2001 January 16. PMCID: PMC14745 What is a moment? Transient synchrony as a collective
mechanism for spatiotemporal integration J. J. Hopfield and Carlos D. Brody Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1282–1287. Published online 2001 January 23. PMCID: PMC14746 Pharmacology Expression of Q227L-Gαs inhibits intimal vessel
wall hyperplasia after balloon injury Wilfred Holness, Tara A. Santore, George P. Brown, John T. Fallon, Mark B. Taubman, and Ravi Iyengar Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1288–1293. PMCID: PMC14747 Reduced susceptibility to ischemic brain injury and
N-methyl-d-aspartate-mediated neurotoxicity
in cyclooxygenase-2-deficient mice Costantino Iadecola, Kiyoshi Niwa, Shigeru Nogawa, Xueren Zhao, Masao Nagayama, Eiichi Araki, Scott Morham, and M. Elizabeth Ross Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1294–1299. PMCID: PMC14748 Physiology Regulation of cystic fibrosis transmembrane conductance regulator
single-channel gating by bivalent PDZ-domain-mediated interaction Viswanathan Raghuram, Don-On Daniel Mak, and J. Kevin Foskett Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1300–1305. Published online 2001 January 23. PMCID: PMC14749 Plant Biology Parthenocarpic apple fruit production conferred by transposon
insertion mutations in a MADS-box transcription factor Jia-Long Yao, Yi-Hu Dong, and Bret A. M. Morris Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1306–1311. Published online 2001 January 23. PMCID: PMC14750 Psychology N-cadherin is regulated by gonadal steroids in the adult
hippocampus Douglas A. Monks, Spiro Getsios, Colin D. MacCalman, and Neil V. Watson Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1312–1316. Published online 2001 January 23. PMCID: PMC14751 Corrections Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1317. Published online 2001 January 23. PMCID: PMC55933 Corrects: Thoralf Optiz, et al. Remodeling of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic
acid receptor subunit composition in hippocampal neurons after
global ischemia. Proc Natl Acad Sci U S A. 2000 November 21; 97(24): 13360–13365. Proc Natl Acad Sci U S A. 2001 January 30; 98(3): 1317. PMCID: PMC55934 Corrects: John McLaughlin, et al. Sparing of neuronal function postseizure with gene therapy. Proc Natl Acad Sci U S A. 2000 November 7; 97(23): 12804–12809. |