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canarypox-hIL-12 melanoma vaccine A vaccine consisting of a replication-defective recombinant canarypox virus (ALVAC) that encodes the gene for human interleukin-12 (hIL-12). Produced mainly by B-cells, IL-12 is an endogenous cytokine that activates natural killer (NK) cells, promotes cytotoxic T lymphocyte (CTL) responses, induces the release of interferon-gamma (IFN-gamma), and may exhibit antitumor and anti-angiogenic effects. Vaccination with canarypox-hIL-12 melanoma vaccine may stimulate the host immune system to mount an immune response against tumor cells, thereby inhibiting tumor growth and/or metastasis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/eot2008/20090115060737im_/http://www.cancer.gov/images/spacer.gif) | ALVAC-hIL-12 ALVAC-hIL-12 melanoma vaccine | | ![](https://webarchive.library.unt.edu/eot2008/20090115060737im_/http://www.cancer.gov/images/spacer.gif) |
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